(49 nodes) P-body network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109983699	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	kiaa0355	Si:ch211-79l17.1. (1087 aa)
	LOC109999730	Uncharacterized protein. (267 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (967 aa)
	LOC109984103	BTB (POZ) domain containing 2b. (510 aa)
	ENSLBEP00000001845	TNRC6-PABC_bdg domain-containing protein. (693 aa)
	LOC109988716	Ajuba LIM protein. (721 aa)
	LOC109980883	Mov10 RISC complex RNA helicase a. (995 aa)
	LOC110002325	C3H1-type domain-containing protein. (956 aa)
	LOC109990537	YTH N(6)-methyladenosine RNA binding protein 2. (646 aa)
	LOC109994634	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (870 aa)
	LOC109987107	Ring finger and CCCH-type domains 2. (866 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1049 aa)
	ybx1	Y box binding protein 1. (303 aa)
	zc3h12b	Zinc finger CCCH-type containing 12B. (848 aa)
	LIMD1	LIM domains containing 1. (596 aa)
	LOC109992333	DNA topoisomerase I. (594 aa)
	ENSLBEP00000010177	Uncharacterized protein. (106 aa)
	pnrc2	Proline-rich nuclear receptor coactivator 2. (158 aa)
	edc4	Enhancer of mRNA decapping 4. (1391 aa)
	LOC109984876	Uncharacterized protein. (763 aa)
	LOC109984893	Uncharacterized protein. (1015 aa)
	LOC109999969	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (880 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (616 aa)
	zc3h12d	C3H1-type domain-containing protein. (556 aa)
	LOC109987876	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (747 aa)
	LOC109979193	C3H1-type domain-containing protein. (926 aa)
	LOC109995424	C3H1-type domain-containing protein. (923 aa)
	mov10l1	Uncharacterized protein. (1143 aa)
	LOC110002584	Enhancer of mRNA decapping 3 homolog (S. cerevisiae). (481 aa)
	LOC109986061	YTH N(6)-methyladenosine RNA binding protein 1. (614 aa)
	mex3b	Mex-3 RNA binding family member B. (481 aa)
	mex3a	RING-type domain-containing protein. (524 aa)
	ythdf3	YTH N(6)-methyladenosine RNA binding protein 3. (552 aa)
	zc3h12a	Si:dkey-206d17.12. (590 aa)
	LOC109983919	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (745 aa)
	LOC109999531	Enhancer of mRNA decapping 3. (475 aa)
	xrn1	5'-3' exoribonuclease 1. (1655 aa)
	LOC109992889	Nanos homolog 2; Belongs to the nanos family. (151 aa)
	ENSLBEP00000024848	Si:dkey-217f16.6. (485 aa)
	LOC109995561	Ring finger and CCCH-type domains 1b. (1115 aa)
	LOC109996183	ELAV-like protein; Belongs to the RRM elav family. (348 aa)
	patl2	PAT1 homolog 2. (726 aa)
	patl1	PAT1 homolog 1, processing body mRNA decay factor. (837 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (810 aa)
	BTBD1	BTB domain containing 1. (469 aa)
	LOC109999113	Zinc finger CCCH-type containing 12A. (627 aa)
	LOC109999124	Lin-28 homolog A. (210 aa)
	LOC110002132	ELAV-like protein; Belongs to the RRM elav family. (359 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD1	LOC109983919	ENSLBEP00000032607	ENSLBEP00000023315	BTB domain containing 1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.411
BTBD1	LOC109987876	ENSLBEP00000032607	ENSLBEP00000015887	BTB domain containing 1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.411
BTBD1	LOC109992333	ENSLBEP00000032607	ENSLBEP00000008807	BTB domain containing 1.	DNA topoisomerase I.	0.411
EIF4ENIF1	ENSLBEP00000010177	ENSLBEP00000001361	ENSLBEP00000010177	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Uncharacterized protein.	0.453
EIF4ENIF1	LOC109987107	ENSLBEP00000001361	ENSLBEP00000006700	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Ring finger and CCCH-type domains 2.	0.551
EIF4ENIF1	LOC109999531	ENSLBEP00000001361	ENSLBEP00000023427	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Enhancer of mRNA decapping 3.	0.491
EIF4ENIF1	LOC110002584	ENSLBEP00000001361	ENSLBEP00000017437	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Enhancer of mRNA decapping 3 homolog (S. cerevisiae).	0.491
EIF4ENIF1	edc4	ENSLBEP00000001361	ENSLBEP00000011961	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Enhancer of mRNA decapping 4.	0.472
EIF4ENIF1	patl1	ENSLBEP00000001361	ENSLBEP00000031308	Eukaryotic translation initiation factor 4E nuclear import factor 1.	PAT1 homolog 1, processing body mRNA decay factor.	0.476
EIF4ENIF1	patl2	ENSLBEP00000001361	ENSLBEP00000029508	Eukaryotic translation initiation factor 4E nuclear import factor 1.	PAT1 homolog 2.	0.476
EIF4ENIF1	xrn1	ENSLBEP00000001361	ENSLBEP00000024551	Eukaryotic translation initiation factor 4E nuclear import factor 1.	5'-3' exoribonuclease 1.	0.448
ENSLBEP00000001845	ENSLBEP00000010177	ENSLBEP00000001845	ENSLBEP00000010177	TNRC6-PABC_bdg domain-containing protein.	Uncharacterized protein.	0.578
ENSLBEP00000001845	LOC109983699	ENSLBEP00000001845	ENSLBEP00000009951	TNRC6-PABC_bdg domain-containing protein.	Argonaute RISC component 1; Belongs to the argonaute family.	0.828
ENSLBEP00000001845	LOC109994634	ENSLBEP00000001845	ENSLBEP00000006650	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.828
ENSLBEP00000001845	LOC109999969	ENSLBEP00000001845	ENSLBEP00000013825	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.828
ENSLBEP00000001845	edc4	ENSLBEP00000001845	ENSLBEP00000011961	TNRC6-PABC_bdg domain-containing protein.	Enhancer of mRNA decapping 4.	0.460
ENSLBEP00000001845	xrn1	ENSLBEP00000001845	ENSLBEP00000024551	TNRC6-PABC_bdg domain-containing protein.	5'-3' exoribonuclease 1.	0.542
ENSLBEP00000010177	EIF4ENIF1	ENSLBEP00000010177	ENSLBEP00000001361	Uncharacterized protein.	Eukaryotic translation initiation factor 4E nuclear import factor 1.	0.453
ENSLBEP00000010177	ENSLBEP00000001845	ENSLBEP00000010177	ENSLBEP00000001845	Uncharacterized protein.	TNRC6-PABC_bdg domain-containing protein.	0.578
ENSLBEP00000010177	ENSLBEP00000024848	ENSLBEP00000010177	ENSLBEP00000024848	Uncharacterized protein.	Si:dkey-217f16.6.	0.578