(43 nodes) Site of double-strand break network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLBEP00000032297	HD domain-containing protein. (528 aa)
	LOC109976756	HD domain-containing protein. (502 aa)
	LOC109976880	Uncharacterized protein. (541 aa)
	LOC109984191	Actin related protein 3; Belongs to the actin family. (408 aa)
	iffo1	Intermediate filament family orphan 1b; Belongs to the intermediate filament family. (643 aa)
	ENSLBEP00000007876	Uncharacterized protein. (265 aa)
	LOC109979647	IF rod domain-containing protein. (165 aa)
	LOC109983927	SET domain and mariner transposase fusion gene. (299 aa)
	ENSLBEP00000024463	HD domain-containing protein. (218 aa)
	LOC109980900	HD domain-containing protein. (602 aa)
	ENSLBEP00000003307	HD domain-containing protein. (592 aa)
	ENSLBEP00000020010	RING-type domain-containing protein. (265 aa)
	ENSLBEP00000019673	HD domain-containing protein. (186 aa)
	LOC109977202	HD domain-containing protein. (479 aa)
	ENSLBEP00000018615	HD domain-containing protein. (495 aa)
	ENSLBEP00000017577	HD domain-containing protein. (565 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (611 aa)
	ACTR3	Actin related protein 3; Belongs to the actin family. (417 aa)
	LOC109992568	ANK_REP_REGION domain-containing protein. (916 aa)
	LOC109990953	Uncharacterized protein. (277 aa)
	LOC109989104	Tonsoku-like, DNA repair protein. (1390 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1256 aa)
	ENSLBEP00000014296	HD domain-containing protein. (518 aa)
	iffo2	Intermediate filament family orphan 2b; Belongs to the intermediate filament family. (484 aa)
	ENSLBEP00000032001	HD_domain domain-containing protein. (195 aa)
	ENSLBEP00000031963	HD domain-containing protein. (529 aa)
	LOC110005387	HD domain-containing protein. (526 aa)
	ENSLBEP00000028573	Zgc:165656. (175 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (525 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (568 aa)
	LOC109977677	Uncharacterized protein. (277 aa)
	smarcad1	Uncharacterized protein. (1058 aa)
	WDR70	WD repeat domain 70. (647 aa)
	ENSLBEP00000024266	Uncharacterized protein. (200 aa)
	ENSLBEP00000024280	ANK_REP_REGION domain-containing protein. (346 aa)
	shld2	Si:ch211-134m17.9. (759 aa)
	ENSLBEP00000001463	HD_domain domain-containing protein. (190 aa)
	ENSLBEP00000001481	HD domain-containing protein. (207 aa)
	ENSLBEP00000026155	HD domain-containing protein. (174 aa)
	ENSLBEP00000027339	HD domain-containing protein. (160 aa)
	ENSLBEP00000026242	HD domain-containing protein. (489 aa)
	ufl1	UFM1-specific ligase 1. (799 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000020010	rnf8	ENSLBEP00000020010	ENSLBEP00000013423	RING-type domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.700
ENSLBEP00000020010	tp53bp1	ENSLBEP00000020010	ENSLBEP00000021742	RING-type domain-containing protein.	Tumor protein p53 binding protein, 1.	0.858
ENSLBEP00000024266	ENSLBEP00000024280	ENSLBEP00000024266	ENSLBEP00000024280	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.959
ENSLBEP00000024266	smarcad1	ENSLBEP00000024266	ENSLBEP00000010492	Uncharacterized protein.	Uncharacterized protein.	0.488
ENSLBEP00000024266	tp53bp1	ENSLBEP00000024266	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.961
ENSLBEP00000024280	ENSLBEP00000024266	ENSLBEP00000024280	ENSLBEP00000024266	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.959
ENSLBEP00000024280	smarcad1	ENSLBEP00000024280	ENSLBEP00000010492	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.488
ENSLBEP00000024280	tp53bp1	ENSLBEP00000024280	ENSLBEP00000021742	ANK_REP_REGION domain-containing protein.	Tumor protein p53 binding protein, 1.	0.961
ENSLBEP00000028573	parp3	ENSLBEP00000028573	ENSLBEP00000015495	Zgc:165656.	Poly [ADP-ribose] polymerase.	0.824
ENSLBEP00000028573	pnkp	ENSLBEP00000028573	ENSLBEP00000015374	Zgc:165656.	Polynucleotide kinase 3'-phosphatase.	0.555
ENSLBEP00000028573	poll	ENSLBEP00000028573	ENSLBEP00000012479	Zgc:165656.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.681
LOC109977677	shld2	ENSLBEP00000011665	ENSLBEP00000000086	Uncharacterized protein.	Si:ch211-134m17.9.	0.934
LOC109977677	tp53bp1	ENSLBEP00000011665	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.419
LOC109983927	tp53bp1	ENSLBEP00000025413	ENSLBEP00000021742	SET domain and mariner transposase fusion gene.	Tumor protein p53 binding protein, 1.	0.487
LOC109989104	rnf8	ENSLBEP00000020051	ENSLBEP00000013423	Tonsoku-like, DNA repair protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.444
LOC109990953	shld2	ENSLBEP00000035546	ENSLBEP00000000086	Uncharacterized protein.	Si:ch211-134m17.9.	0.934
LOC109990953	tp53bp1	ENSLBEP00000035546	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.419
LOC109992568	rnf8	ENSLBEP00000036202	ENSLBEP00000013423	ANK_REP_REGION domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.444
parp3	ENSLBEP00000028573	ENSLBEP00000015495	ENSLBEP00000028573	Poly [ADP-ribose] polymerase.	Zgc:165656.	0.824
parp3	pnkp	ENSLBEP00000015495	ENSLBEP00000015374	Poly [ADP-ribose] polymerase.	Polynucleotide kinase 3'-phosphatase.	0.412