(23 nodes) Histidine kinase/HSP90-like ATPase superfamily network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (648 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1440 aa)
	pdk3	Protein-serine/threonine kinase. (406 aa)
	pdk1	Protein-serine/threonine kinase. (406 aa)
	LOC109982952	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (722 aa)
	ENSLBEP00000036265	Morc6_S5 domain-containing protein. (307 aa)
	trap1	TNF receptor-associated protein 1. (709 aa)
	LOC109991828	Protein-serine/threonine kinase. (414 aa)
	LOC109982928	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (736 aa)
	ENSLBEP00000011263	Uncharacterized protein. (261 aa)
	bckdk	Protein-serine/threonine kinase. (427 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (852 aa)
	hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (725 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1491 aa)
	pms1	PMS1 homolog 1, mismatch repair system component. (1093 aa)
	LOC109987450	Wu:fj29h11. (2647 aa)
	ENSLBEP00000002520	HEPN domain-containing protein. (4311 aa)
	LOC109994633	Protein-serine/threonine kinase. (408 aa)
	LOC109995925	Protein-serine/threonine kinase. (409 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (785 aa)
	sacs	Uncharacterized protein. (715 aa)
	ENSLBEP00000016854	Sacsin molecular chaperone. (2841 aa)
	morc2	MORC family CW-type zinc finger 2. (1042 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000002520	top2a	ENSLBEP00000002520	ENSLBEP00000020364	HEPN domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.460
ENSLBEP00000002520	top2b	ENSLBEP00000002520	ENSLBEP00000036950	HEPN domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.460
ENSLBEP00000016854	top2a	ENSLBEP00000016854	ENSLBEP00000020364	Sacsin molecular chaperone.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.460
ENSLBEP00000016854	top2b	ENSLBEP00000016854	ENSLBEP00000036950	Sacsin molecular chaperone.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.460
LOC109982928	LOC109991828	ENSLBEP00000031902	ENSLBEP00000009691	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.539
LOC109982928	LOC109994633	ENSLBEP00000031902	ENSLBEP00000006325	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.539
LOC109982928	LOC109995925	ENSLBEP00000031902	ENSLBEP00000013867	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.539
LOC109982928	bckdk	ENSLBEP00000031902	ENSLBEP00000011956	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.546
LOC109982928	hsp90ab1	ENSLBEP00000031902	ENSLBEP00000013706	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.832
LOC109982928	hsp90b1	ENSLBEP00000031902	ENSLBEP00000015377	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, beta (grp94), member 1.	0.895
LOC109982928	pdk1	ENSLBEP00000031902	ENSLBEP00000024430	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.539
LOC109982928	pdk3	ENSLBEP00000031902	ENSLBEP00000022712	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.539
LOC109982952	LOC109991828	ENSLBEP00000031834	ENSLBEP00000009691	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.539
LOC109982952	LOC109994633	ENSLBEP00000031834	ENSLBEP00000006325	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.539
LOC109982952	LOC109995925	ENSLBEP00000031834	ENSLBEP00000013867	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.539
LOC109982952	bckdk	ENSLBEP00000031834	ENSLBEP00000011956	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.546
LOC109982952	hsp90ab1	ENSLBEP00000031834	ENSLBEP00000013706	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.832
LOC109982952	hsp90b1	ENSLBEP00000031834	ENSLBEP00000015377	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, beta (grp94), member 1.	0.895
LOC109982952	pdk1	ENSLBEP00000031834	ENSLBEP00000024430	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.539
LOC109982952	pdk3	ENSLBEP00000031834	ENSLBEP00000022712	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Protein-serine/threonine kinase.	0.539