(71 nodes) Signaling by NOTCH network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hey1	Hes-related family bHLH transcription factor with YRPW motif 1. (332 aa)
	IKZF4	IKAROS family zinc finger 4. (587 aa)
	lrba	LPS-responsive vesicle trafficking, beach and anchor containing. (2746 aa)
	LOC109991446	PBC domain-containing protein. (117 aa)
	LOC109985524	Pre-B-cell leukemia homeobox 1a. (325 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1005 aa)
	nbea	Neurobeachin a. (2397 aa)
	ENSLBEP00000027786	Uncharacterized protein. (76 aa)
	hes4	Hairy-related 9. (288 aa)
	ENSLBEP00000028819	TACC_C domain-containing protein. (315 aa)
	LOC109989219	Pre-B-cell leukemia transcription factor 4. (460 aa)
	LOC109996204	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (410 aa)
	LOC109990911	Hes related family bHLH transcription factor with YRPW motif like. (330 aa)
	ikzf1	IKAROS family zinc finger 1 (Ikaros). (517 aa)
	CRB2	Uncharacterized protein. (1447 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (642 aa)
	pbx3	Homeobox domain-containing protein. (485 aa)
	LOC109997861	Beta-1,3-N-acetylglucosaminyltransferase. (365 aa)
	LOC109995620	Homeobox domain-containing protein. (373 aa)
	LOC110000256	Deltex 2, E3 ubiquitin ligase. (567 aa)
	dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
	LOC109994980	Uncharacterized protein. (310 aa)
	hes1	Hairy-related 6. (277 aa)
	LOC110002750	Uncharacterized protein. (757 aa)
	LOC110004069	ETS-related transcription factor Elf-3-like. (388 aa)
	LOC110001970	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	LOC109980728	Deltex 4, E3 ubiquitin ligase a. (772 aa)
	dner	Delta/notch-like EGF repeat containing. (772 aa)
	notch1	Notch receptor 1b. (2506 aa)
	LOC109988038	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (223 aa)
	pofut1	Protein O-fucosyltransferase 1. (390 aa)
	crb1	Crumbs cell polarity complex component 1. (1298 aa)
	LOC109998483	Notch receptor 1a. (2336 aa)
	neurl1b	Neuralized E3 ubiquitin protein ligase 1B. (562 aa)
	LOC109980785	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (595 aa)
	crb2	Crumbs cell polarity complex component 2b. (1413 aa)
	ubb	Ubiquitin B. (759 aa)
	egf	Epidermal growth factor. (1031 aa)
	poglut1	Protein O-glucosyltransferase 1. (388 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (235 aa)
	prkci	Protein kinase C. (594 aa)
	LOC109989589	Homeobox domain-containing protein. (332 aa)
	ENSLBEP00000016851	Uncharacterized protein. (1537 aa)
	ENSLBEP00000016803	Uncharacterized protein. (261 aa)
	LOC109991236	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (358 aa)
	LOC109984943	IKAROS family zinc finger 4. (561 aa)
	LOC109991952	Hairy-related 8.2. (197 aa)
	LOC109983142	Uncharacterized protein. (388 aa)
	LOC109987849	Neuralized E3 ubiquitin protein ligase 1Aa. (591 aa)
	ENSLBEP00000012199	Uncharacterized protein. (674 aa)
	LOC109996944	Beta-1,3-N-acetylglucosaminyltransferase. (408 aa)
	LOC109991416	Beta-1,3-N-acetylglucosaminyltransferase. (367 aa)
	LOC109983660	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (806 aa)
	LOC109996217	Uncharacterized protein. (238 aa)
	DLK1	Delta like non-canonical Notch ligand 1. (392 aa)
	LOC109980837	E3 ubiquitin-protein ligase. (867 aa)
	LOC109981934	Uncharacterized protein. (577 aa)
	LOC109984743	Neurobeachin b. (2904 aa)
	ENSLBEP00000003280	Uncharacterized protein. (247 aa)
	LOC109985385	IKAROS family zinc finger 2. (515 aa)
	LOC109988825	Pre-B-cell leukemia homeobox 2. (352 aa)
	LOC109988232	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
	ehf	Ets homologous factor. (274 aa)
	pbx1	Homeobox domain-containing protein. (449 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC109988183	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	LOC109981265	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (707 aa)
	LOC110005906	RING-type domain-containing protein. (314 aa)
	ENSLBEP00000021845	Uncharacterized protein. (493 aa)
	LOC109985574	E3 ubiquitin-protein ligase. (880 aa)
	maml3	Mastermind-like transcriptional coactivator 3. (1171 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRB2	DTX1	ENSLBEP00000030638	ENSLBEP00000030663	Uncharacterized protein.	Deltex E3 ubiquitin ligase 1.	0.474
CRB2	LOC109980728	ENSLBEP00000030638	ENSLBEP00000034399	Uncharacterized protein.	Deltex 4, E3 ubiquitin ligase a.	0.474
CRB2	LOC109988232	ENSLBEP00000030638	ENSLBEP00000002317	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.451
CRB2	LOC109991236	ENSLBEP00000030638	ENSLBEP00000016278	Uncharacterized protein.	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.468
CRB2	LOC109991416	ENSLBEP00000030638	ENSLBEP00000011695	Uncharacterized protein.	Beta-1,3-N-acetylglucosaminyltransferase.	0.468
CRB2	LOC109996204	ENSLBEP00000030638	ENSLBEP00000029818	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.451
CRB2	LOC109996944	ENSLBEP00000030638	ENSLBEP00000011814	Uncharacterized protein.	Beta-1,3-N-acetylglucosaminyltransferase.	0.468
CRB2	LOC109997861	ENSLBEP00000030638	ENSLBEP00000031117	Uncharacterized protein.	Beta-1,3-N-acetylglucosaminyltransferase.	0.468
CRB2	LOC109998483	ENSLBEP00000030638	ENSLBEP00000037222	Uncharacterized protein.	Notch receptor 1a.	0.502
CRB2	LOC110000256	ENSLBEP00000030638	ENSLBEP00000031490	Uncharacterized protein.	Deltex 2, E3 ubiquitin ligase.	0.474
CRB2	LOC110002750	ENSLBEP00000030638	ENSLBEP00000033243	Uncharacterized protein.	Uncharacterized protein.	0.474
CRB2	LOC110005906	ENSLBEP00000030638	ENSLBEP00000021469	Uncharacterized protein.	RING-type domain-containing protein.	0.477
CRB2	maml3	ENSLBEP00000030638	ENSLBEP00000023730	Uncharacterized protein.	Mastermind-like transcriptional coactivator 3.	0.574
CRB2	notch1	ENSLBEP00000030638	ENSLBEP00000035814	Uncharacterized protein.	Notch receptor 1b.	0.502
CRB2	prkci	ENSLBEP00000030638	ENSLBEP00000017764	Uncharacterized protein.	Protein kinase C.	0.468
CRB2	rps27a	ENSLBEP00000030638	ENSLBEP00000000668	Uncharacterized protein.	Ribosomal protein S27a.	0.473
CRB2	tmed2	ENSLBEP00000030638	ENSLBEP00000018996	Uncharacterized protein.	Transmembrane p24 trafficking protein 2.	0.445
DLK1	LOC109998483	ENSLBEP00000006835	ENSLBEP00000037222	Delta like non-canonical Notch ligand 1.	Notch receptor 1a.	0.648
DLK1	egf	ENSLBEP00000006835	ENSLBEP00000020653	Delta like non-canonical Notch ligand 1.	Epidermal growth factor.	0.525
DLK1	notch1	ENSLBEP00000006835	ENSLBEP00000035814	Delta like non-canonical Notch ligand 1.	Notch receptor 1b.	0.648