(151 nodes) Telomere Maintenance network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLBEP00000000332	Histone H2B; Belongs to the histone H2B family. (114 aa)
	ENSLBEP00000013333	annotation not available (96 aa)
	ENSLBEP00000013232	Histone H2A; Belongs to the histone H2A family. (129 aa)
	ENSLBEP00000012771	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
	ENSLBEP00000012749	Histone H2A; Belongs to the histone H2A family. (108 aa)
	stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
	dna2	DNA replication helicase/nuclease 2. (1384 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	ankrd28	Ankyrin repeat domain 28b. (1052 aa)
	wrap53	WD repeat containing, antisense to TP53. (554 aa)
	LOC109996043	Zgc:110269. (347 aa)
	LOC109989819	Uncharacterized protein. (448 aa)
	ENSLBEP00000009388	Histone H2A; Belongs to the histone H2A family. (144 aa)
	LOC110006071	Daxx domain-containing protein. (746 aa)
	chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (137 aa)
	ENSLBEP00000008553	Histone H2A; Belongs to the histone H2A family. (135 aa)
	LOC109975983	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	LOC109976453-2	Histone H2B-like. (122 aa)
	ENSLBEP00000008381	Histone H2B; Belongs to the histone H2B family. (118 aa)
	ENSLBEP00000008363	Histone H2A; Belongs to the histone H2A family. (130 aa)
	ENSLBEP00000000205	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (147 aa)
	dscc1	DNA replication and sister chromatid cohesion 1. (368 aa)
	ENSLBEP00000008332	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (84 aa)
	ENSLBEP00000008291	Histone H2B; Belongs to the histone H2B family. (117 aa)
	ENSLBEP00000008223	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
	LOC109987076	RPA_C domain-containing protein. (257 aa)
	ENSLBEP00000001763	Histone H2B; Belongs to the histone H2B family. (67 aa)
	LOC109988732	TERF1 (TRF1)-interacting nuclear factor 2. (557 aa)
	nhp2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (155 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (705 aa)
	ENSLBEP00000004009	Histone H2B; Belongs to the histone H2B family. (123 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ENSLBEP00000004684	Histone H2B; Belongs to the histone H2B family. (113 aa)
	ENSLBEP00000004710	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (161 aa)
	pot1	Protection of telomeres 1 homolog. (718 aa)
	ENSLBEP00000005132	Telo_bind domain-containing protein. (305 aa)
	rfc1	Replication factor C subunit 1. (1024 aa)
	ENSLBEP00000005682	Uncharacterized protein. (1420 aa)
	LOC109977742	Ankyrin repeat domain 66. (168 aa)
	ENSLBEP00000005965	RFC1 domain-containing protein. (117 aa)
	ENSLBEP00000005983	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	chtf18	AAA domain-containing protein. (918 aa)
	ruvbl2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (492 aa)
	ENSLBEP00000006855	HTH myb-type domain-containing protein. (181 aa)
	ENSLBEP00000006873	Uncharacterized protein. (125 aa)
	ENSLBEP00000007283	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
	ENSLBEP00000007408	Histone H2B; Belongs to the histone H2B family. (117 aa)
	pif1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (614 aa)
	LOC110002822	Histone H2A; Belongs to the histone H2A family. (120 aa)
	ENSLBEP00000007755	Histone H2B; Belongs to the histone H2B family. (123 aa)
	LOC109976452	Histone H2A; Belongs to the histone H2A family. (131 aa)
	ENSLBEP00000008057	Histone H2A; Belongs to the histone H2A family. (127 aa)
	lig1	DNA ligase. (767 aa)
	LOC109976453	Histone H2B; Belongs to the histone H2B family. (122 aa)
	LOC109975983-6	Histone H4. (103 aa)
	ENSLBEP00000032296	Histone H2B; Belongs to the histone H2B family. (118 aa)
	LOC109982406	ANK_REP_REGION domain-containing protein. (1068 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1108 aa)
	ENSLBEP00000031072	Histone H2A; Belongs to the histone H2A family. (153 aa)
	pold1	DNA polymerase. (1126 aa)
	ENSLBEP00000030915	annotation not available (117 aa)
	ENSLBEP00000030820	Histone H2A; Belongs to the histone H2A family. (137 aa)
	LOC109975370	Uncharacterized protein. (330 aa)
	ENSLBEP00000030671	annotation not available (93 aa)
	ENSLBEP00000030621	annotation not available (67 aa)
	LOC109987419	Histone H2B-like. (122 aa)
	ENSLBEP00000030418	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (152 aa)
	ENSLBEP00000030154	Histone H2A; Belongs to the histone H2A family. (119 aa)
	LOC109975983-5	Histone H4. (103 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	LOC109975983-4	Histone H4. (103 aa)
	ENSLBEP00000029834	Histone H2B; Belongs to the histone H2B family. (116 aa)
	ankrd44	Ankyrin repeat domain 44. (919 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (605 aa)
	ENSLBEP00000027645	Histone H2A; Belongs to the histone H2A family. (133 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (393 aa)
	LOC109985734	Histone H2A; Belongs to the histone H2A family. (135 aa)
	ENSLBEP00000026818	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (474 aa)
	ENSLBEP00000026682	Histone H2B; Belongs to the histone H2B family. (127 aa)
	ENSLBEP00000026408	Histone H2B; Belongs to the histone H2B family. (117 aa)
	ENSLBEP00000026317	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
	LOC109986892	Histone H2B; Belongs to the histone H2B family. (132 aa)
	ENSLBEP00000026225	Histone H2A; Belongs to the histone H2A family. (131 aa)
	ENSLBEP00000026111	Histone H2B; Belongs to the histone H2B family. (114 aa)
	LOC110002098	Exonuclease 3'-5' domain containing 2. (633 aa)
	PPP6C	Serine/threonine-protein phosphatase. (305 aa)
	meiob	Methionine sulfoxide reductase B1b. (438 aa)
	ENSLBEP00000032594	annotation not available (93 aa)
	ENSLBEP00000032677	Histone H2B; Belongs to the histone H2B family. (117 aa)
	ENSLBEP00000032736	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
	ENSLBEP00000032858	annotation not available (117 aa)
	ENSLBEP00000032871	Histone H2A; Belongs to the histone H2A family. (132 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	ENSLBEP00000033002	annotation not available (117 aa)
	ENSLBEP00000033085	Histone H2A; Belongs to the histone H2A family. (138 aa)
	terf2ip	Uncharacterized protein. (736 aa)
	ENSLBEP00000033715	Histone H2A; Belongs to the histone H2A family. (131 aa)
	ENSLBEP00000033924	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (143 aa)
	ENSLBEP00000033952	Histone H2A; Belongs to the histone H2A family. (104 aa)
	ENSLBEP00000033968	Histone H2B; Belongs to the histone H2B family. (132 aa)
	LOC114921852	Histone H4-like. (79 aa)
	ENSLBEP00000034524	Histone H2A; Belongs to the histone H2A family. (136 aa)
	ENSLBEP00000034610	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
	LOC109987416	Histone H2A; Belongs to the histone H2A family. (128 aa)
	LOC110003529	Death-domain associated protein. (755 aa)
	atrx	ATRX chromatin remodeler. (2243 aa)
	trub1	TruB pseudouridine (psi) synthase family member 1. (286 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
	rpa2	Replication protein A2. (274 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC109976454	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
	pold4	Si:dkey-28b4.7. (111 aa)
	LOC109988560	Serine/threonine-protein phosphatase. (305 aa)
	ENSLBEP00000025525	Histone H2B; Belongs to the histone H2B family. (117 aa)
	ENSLBEP00000025489	Histone H2B; Belongs to the histone H2B family. (117 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
	ENSLBEP00000025284	annotation not available (130 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1-like. (531 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (487 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (846 aa)
	LOC109978538	RCC1 and BTB domain containing protein 1. (531 aa)
	ENSLBEP00000023011	annotation not available (130 aa)
	ENSLBEP00000022791	Uncharacterized protein. (58 aa)
	pola1	DNA polymerase. (1476 aa)
	ENSLBEP00000022210	Histone H2A; Belongs to the histone H2A family. (107 aa)
	ENSLBEP00000022186	annotation not available (95 aa)
	ENSLBEP00000032486	Histone H2A; Belongs to the histone H2A family. (129 aa)
	LOC109975980	Uncharacterized protein; Belongs to the histone H2B family. (79 aa)
	LOC109976346	Histone H2B-like. (122 aa)
	ENSLBEP00000021185	annotation not available (95 aa)
	LOC109998245	Cyclin A2; Belongs to the cyclin family. (441 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ENSLBEP00000020673	RecQ helicase-like 4. (781 aa)
	gar1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (275 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1179 aa)
	ENSLBEP00000019666	Histone H2A; Belongs to the histone H2A family. (118 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	terf1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa)
	LOC109991317	Histone H2A; Belongs to the histone H2A family. (128 aa)
	ENSLBEP00000018281	Histone H2B; Belongs to the histone H2B family. (126 aa)
	LOC109975983-3	Histone H4. (103 aa)
	ENSLBEP00000018170	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
	ENSLBEP00000018008	annotation not available (67 aa)
	rfc2	Replication factor C (activator 1) 2. (233 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa)
	LOC110000833	Histone H2B; Belongs to the histone H2B family. (122 aa)
	LOC109975983-2	Histone H4. (103 aa)
	ten1	TEN1 subunit of CST complex. (134 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000205	ENSLBEP00000000332	ENSLBEP00000000205	ENSLBEP00000000332	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.559
ENSLBEP00000000205	ENSLBEP00000001763	ENSLBEP00000000205	ENSLBEP00000001763	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.645
ENSLBEP00000000205	ENSLBEP00000004009	ENSLBEP00000000205	ENSLBEP00000004009	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.645
ENSLBEP00000000205	ENSLBEP00000004684	ENSLBEP00000000205	ENSLBEP00000004684	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.645
ENSLBEP00000000205	ENSLBEP00000005682	ENSLBEP00000000205	ENSLBEP00000005682	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Uncharacterized protein.	0.442
ENSLBEP00000000205	ENSLBEP00000006873	ENSLBEP00000000205	ENSLBEP00000006873	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Uncharacterized protein.	0.427
ENSLBEP00000000205	ENSLBEP00000007408	ENSLBEP00000000205	ENSLBEP00000007408	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.575
ENSLBEP00000000205	ENSLBEP00000007755	ENSLBEP00000000205	ENSLBEP00000007755	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.645
ENSLBEP00000000205	ENSLBEP00000008057	ENSLBEP00000000205	ENSLBEP00000008057	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000008291	ENSLBEP00000000205	ENSLBEP00000008291	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.559
ENSLBEP00000000205	ENSLBEP00000008363	ENSLBEP00000000205	ENSLBEP00000008363	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000008381	ENSLBEP00000000205	ENSLBEP00000008381	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.575
ENSLBEP00000000205	ENSLBEP00000008553	ENSLBEP00000000205	ENSLBEP00000008553	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000009388	ENSLBEP00000000205	ENSLBEP00000009388	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.750
ENSLBEP00000000205	ENSLBEP00000012749	ENSLBEP00000000205	ENSLBEP00000012749	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000013232	ENSLBEP00000000205	ENSLBEP00000013232	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000018008	ENSLBEP00000000205	ENSLBEP00000018008	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	annotation not available	0.551
ENSLBEP00000000205	ENSLBEP00000018281	ENSLBEP00000000205	ENSLBEP00000018281	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2B; Belongs to the histone H2B family.	0.645
ENSLBEP00000000205	ENSLBEP00000019666	ENSLBEP00000000205	ENSLBEP00000019666	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575
ENSLBEP00000000205	ENSLBEP00000022210	ENSLBEP00000000205	ENSLBEP00000022210	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Histone H2A; Belongs to the histone H2A family.	0.575

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