(56 nodes) Gamma carboxylation, hypusine formation and arylsulfatase activation network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	sumf1	Sulfatase modifying factor 1. (356 aa)
	SUMF2	Sulfatase modifying factor 2. (285 aa)
	sts	Steroid sulfatase (microsomal), isozyme S. (659 aa)
	tpst1	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (353 aa)
	LOC109975400	Diphthamide biosynthesis 5. (290 aa)
	furin	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (839 aa)
	LOC109984051	Eukaryotic translation elongation factor 2b. (857 aa)
	LOC109989887	Sulfatase domain-containing protein. (767 aa)
	dph7	Diphthamide biosynthesis 7. (421 aa)
	LOC109999252	PRELI/MSF1 domain-containing protein. (204 aa)
	LOC109985371	Arylsulfatase H. (598 aa)
	LOC110001549	Coagulation factor IXb. (533 aa)
	dohh	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (305 aa)
	LOC109994113	SEC14-like lipid binding 1. (710 aa)
	LOC109995348	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (380 aa)
	dnajc24	Uncharacterized protein. (169 aa)
	arsg	Arylsulfatase G. (517 aa)
	LOC110004484	Uncharacterized protein. (494 aa)
	f9	Coagulation factor IXa. (514 aa)
	LOC110000544	SEC14-like lipid binding 7. (350 aa)
	f2	Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (614 aa)
	pros1	Protein S. (679 aa)
	gas6	Growth arrest-specific 6. (627 aa)
	arsj	Arylsulfatase family, member J. (609 aa)
	ENSLBEP00000018843	PRELI/MSF1 domain-containing protein. (86 aa)
	arsa	Arylsulfatase A. (501 aa)
	LOC110000633	Deoxyhypusine synthase. (364 aa)
	icmt	Protein-S-isoprenylcysteine O-methyltransferase. (291 aa)
	LOC110000623	Uncharacterized protein. (358 aa)
	LOC109993124	eIF-5a domain-containing protein. (216 aa)
	LOC109975945	TP_methylase domain-containing protein. (294 aa)
	LOC109982733	Tr-type G domain-containing protein. (858 aa)
	LOC109989133	SEC14-like lipid binding 8. (391 aa)
	arsk	Arylsulfatase family, member K. (567 aa)
	LOC109999601	Eukaryotic translation initiation factor 5A. (154 aa)
	LOC110000203	Fructosamine 3 kinase related protein; Belongs to the fructosamine kinase family. (309 aa)
	dph1	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (412 aa)
	ARSB	Arylsulfatase B. (518 aa)
	ggcx	Gamma-glutamyl carboxylase. (771 aa)
	LOC109975720	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (814 aa)
	LOC109985885	Protein Z, vitamin K-dependent plasma glycoprotein a; Belongs to the peptidase S1 family. (426 aa)
	LOC110002786	Gla domain-containing protein. (167 aa)
	EIF5AL1	Eukaryotic translation initiation factor 5A. (173 aa)
	arsi	Arylsulfatase family, member Ia. (576 aa)
	LOC109997365	Si:dkey-174i8.1. (559 aa)
	bglap	Gla domain-containing protein. (81 aa)
	dph2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (507 aa)
	dph6	Diphthamine biosynthesis 6. (466 aa)
	LOC110002094	Protein Z, vitamin K-dependent plasma glycoprotein b; Belongs to the peptidase S1 family. (558 aa)
	ENSLBEP00000038058	Coagulation factor X. (502 aa)
	ENSLBEP00000038064	Coagulation factor VIIi. (458 aa)
	LOC110002084	Coagulation factor VII. (447 aa)
	LOC110002085	Coagulation factor VII, like. (433 aa)
	proc	Protein C (inactivator of coagulation factors Va and VIIIa), a. (437 aa)
	ENSLBEP00000038813	Gla domain-containing protein. (95 aa)
	ENSLBEP00000038814	Kringle domain-containing protein. (142 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	LOC109985371	ENSLBEP00000028751	ENSLBEP00000005134	Arylsulfatase B.	Arylsulfatase H.	0.813
ARSB	SUMF2	ENSLBEP00000028751	ENSLBEP00000000076	Arylsulfatase B.	Sulfatase modifying factor 2.	0.736
ARSB	arsa	ENSLBEP00000028751	ENSLBEP00000019524	Arylsulfatase B.	Arylsulfatase A.	0.909
ARSB	arsg	ENSLBEP00000028751	ENSLBEP00000011603	Arylsulfatase B.	Arylsulfatase G.	0.911
ARSB	arsk	ENSLBEP00000028751	ENSLBEP00000025161	Arylsulfatase B.	Arylsulfatase family, member K.	0.735
ARSB	dohh	ENSLBEP00000028751	ENSLBEP00000009878	Arylsulfatase B.	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.	0.569
ARSB	sts	ENSLBEP00000028751	ENSLBEP00000001030	Arylsulfatase B.	Steroid sulfatase (microsomal), isozyme S.	0.814
ARSB	sumf1	ENSLBEP00000028751	ENSLBEP00000023997	Arylsulfatase B.	Sulfatase modifying factor 1.	0.778
EIF5AL1	LOC109982733	ENSLBEP00000035194	ENSLBEP00000021960	Eukaryotic translation initiation factor 5A.	Tr-type G domain-containing protein.	0.964
EIF5AL1	LOC109984051	ENSLBEP00000035194	ENSLBEP00000001554	Eukaryotic translation initiation factor 5A.	Eukaryotic translation elongation factor 2b.	0.964
EIF5AL1	LOC110000623	ENSLBEP00000035194	ENSLBEP00000020040	Eukaryotic translation initiation factor 5A.	Uncharacterized protein.	0.962
EIF5AL1	LOC110000633	ENSLBEP00000035194	ENSLBEP00000019671	Eukaryotic translation initiation factor 5A.	Deoxyhypusine synthase.	0.981
EIF5AL1	dohh	ENSLBEP00000035194	ENSLBEP00000009878	Eukaryotic translation initiation factor 5A.	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.	0.958
ENSLBEP00000018843	sumf1	ENSLBEP00000018843	ENSLBEP00000023997	PRELI/MSF1 domain-containing protein.	Sulfatase modifying factor 1.	0.594
ENSLBEP00000038058	ENSLBEP00000038813	ENSLBEP00000038058	ENSLBEP00000038813	Coagulation factor X.	Gla domain-containing protein.	0.798
ENSLBEP00000038058	ENSLBEP00000038814	ENSLBEP00000038058	ENSLBEP00000038814	Coagulation factor X.	Kringle domain-containing protein.	0.798
ENSLBEP00000038058	LOC109975720	ENSLBEP00000038058	ENSLBEP00000031488	Coagulation factor X.	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	0.584
ENSLBEP00000038058	LOC110001549	ENSLBEP00000038058	ENSLBEP00000008243	Coagulation factor X.	Coagulation factor IXb.	0.514
ENSLBEP00000038058	LOC110002084	ENSLBEP00000038058	ENSLBEP00000038068	Coagulation factor X.	Coagulation factor VII.	0.512
ENSLBEP00000038058	f2	ENSLBEP00000038058	ENSLBEP00000015302	Coagulation factor X.	Coagulation factor II (thrombin); Belongs to the peptidase S1 family.	0.816