(30 nodes) Metabolism of nitric oxide: NOS3 activation and regulation network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	nostrin	Nitric oxide synthase trafficking. (574 aa)
	LOC109989222	Dynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (878 aa)
	recql	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (842 aa)
	LOC109996204	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (410 aa)
	LOC109987914	FH2 domain-containing protein. (351 aa)
	LOC109981635	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (251 aa)
	SPR	Sepiapterin reductase. (264 aa)
	LOC109988544	Sepiapterin reductase b. (264 aa)
	ENSLBEP00000025231	Uncharacterized protein. (215 aa)
	LOC109988409	Formin 1. (907 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (168 aa)
	LOC109996499	GLOBIN domain-containing protein; Belongs to the globin family. (178 aa)
	LOC109989547	Dynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (837 aa)
	was	WASP actin nucleation promoting factor a. (464 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC109990113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	ENSLBEP00000010885	Uncharacterized protein. (533 aa)
	ddah2	Dimethylarginine dimethylaminohydrolase 2. (292 aa)
	LOC109976813	FH2 domain-containing protein. (182 aa)
	LOC109984860	WASP like actin nucleation promoting factor a. (547 aa)
	LOC109991691	WASP like actin nucleation promoting factor b. (501 aa)
	LOC109988232	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	nosip	Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity; Belongs to the NOSIP family. (290 aa)
	ENSLBEP00000004810	CRIB domain-containing protein. (344 aa)
	FMN1	Formin 1. (1349 aa)
	ENSLBEP00000033875	FH2 domain-containing protein. (210 aa)
	LOC109999711	Cytoglobin 2; Belongs to the globin family. (180 aa)
	LOC109982928	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (736 aa)
	LOC109982952	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (722 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDAH1	ENSLBEP00000025231	ENSLBEP00000018003	ENSLBEP00000025231	Dimethylarginine dimethylaminohydrolase 1.	Uncharacterized protein.	0.529
ENSLBEP00000004810	LOC109989222	ENSLBEP00000004810	ENSLBEP00000031494	CRIB domain-containing protein.	Dynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.556
ENSLBEP00000004810	LOC109989547	ENSLBEP00000004810	ENSLBEP00000016159	CRIB domain-containing protein.	Dynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.556
ENSLBEP00000004810	LOC109990113	ENSLBEP00000004810	ENSLBEP00000015571	CRIB domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.634
ENSLBEP00000004810	nostrin	ENSLBEP00000004810	ENSLBEP00000006171	CRIB domain-containing protein.	Nitric oxide synthase trafficking.	0.735
ENSLBEP00000010885	LOC109989222	ENSLBEP00000010885	ENSLBEP00000031494	Uncharacterized protein.	Dynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.556
ENSLBEP00000010885	LOC109989547	ENSLBEP00000010885	ENSLBEP00000016159	Uncharacterized protein.	Dynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.556
ENSLBEP00000010885	LOC109990113	ENSLBEP00000010885	ENSLBEP00000015571	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.634
ENSLBEP00000010885	nostrin	ENSLBEP00000010885	ENSLBEP00000006171	Uncharacterized protein.	Nitric oxide synthase trafficking.	0.735
ENSLBEP00000025231	DDAH1	ENSLBEP00000025231	ENSLBEP00000018003	Uncharacterized protein.	Dimethylarginine dimethylaminohydrolase 1.	0.529
ENSLBEP00000025231	ddah2	ENSLBEP00000025231	ENSLBEP00000009353	Uncharacterized protein.	Dimethylarginine dimethylaminohydrolase 2.	0.521
ENSLBEP00000033875	nostrin	ENSLBEP00000033875	ENSLBEP00000006171	FH2 domain-containing protein.	Nitric oxide synthase trafficking.	0.438
FMN1	nostrin	ENSLBEP00000035492	ENSLBEP00000006171	Formin 1.	Nitric oxide synthase trafficking.	0.438
LOC109976813	LOC109988409	ENSLBEP00000006399	ENSLBEP00000020320	FH2 domain-containing protein.	Formin 1.	0.647
LOC109976813	nostrin	ENSLBEP00000006399	ENSLBEP00000006171	FH2 domain-containing protein.	Nitric oxide synthase trafficking.	0.438
LOC109982928	LOC109988232	ENSLBEP00000031902	ENSLBEP00000002317	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.846
LOC109982928	LOC109988544	ENSLBEP00000031902	ENSLBEP00000027117	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Sepiapterin reductase b.	0.665
LOC109982928	LOC109990113	ENSLBEP00000031902	ENSLBEP00000015571	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.856
LOC109982928	LOC109996204	ENSLBEP00000031902	ENSLBEP00000029818	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.846
LOC109982928	SPR	ENSLBEP00000031902	ENSLBEP00000027141	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Sepiapterin reductase.	0.665