(51 nodes) The canonical retinoid cycle in rods (twilight vision) network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109993409	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (157 aa)
	rbp3	Interphotoreceptor retinoid-binding protein like. (917 aa)
	LOC109992289	Retinol binding protein 3. (617 aa)
	LOC109997406	Rhodopsin. (349 aa)
	smpdl3a	Acid sphingomyelinase-like phosphodiesterase. (443 aa)
	LOC109988252	Cytochrome P450, family 4, subfamily V, polypeptide 8; Belongs to the cytochrome P450 family. (518 aa)
	LOC110002301	Rhodopsin. (354 aa)
	LOC110002300	Rhodopsin. (352 aa)
	LOC110002302	Rhodopsin. (352 aa)
	LOC109988302	LRAT domain-containing protein. (214 aa)
	lrat	Lecithin retinol acyltransferase a. (228 aa)
	LOC110005568	Uncharacterized protein; Belongs to the cytochrome P450 family. (477 aa)
	LOC109986569	Retinoid isomerohydrolase RPE65 b. (533 aa)
	LOC109991778	Retinol dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (340 aa)
	LOC109980857	Retinol dehydrogenase 5 (11-cis/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
	LOC109991786	Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
	rlbp1	Retinaldehyde binding protein 1b. (309 aa)
	ENSLBEP00000006166	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	ENSLBEP00000006251	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (183 aa)
	LOC109977538	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	RHO	Extra-ocular rhodopsin. (326 aa)
	rbp4	Retinol binding protein 4, plasma; Belongs to the calycin superfamily. Lipocalin family. (194 aa)
	ENSLBEP00000011867	Rhodopsin. (345 aa)
	LOC109976169	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
	PTCHD3	Patched domain containing 3. (850 aa)
	LOC109992372	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	LOC109991256	Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2173 aa)
	ENSLBEP00000013509	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (203 aa)
	LOC110004546	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
	LOC109990122	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (382 aa)
	rpe65	Retinoid isomerohydrolase RPE65 a. (531 aa)
	ptchd1	Patched domain containing 1. (969 aa)
	ENSLBEP00000016937	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC109978199	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
	LOC109984981	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	LOC109985053	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (195 aa)
	LOC109984980	Apolipoprotein D-like. (169 aa)
	ENSLBEP00000017620	Uncharacterized protein. (809 aa)
	rdh10	Retinol dehydrogenase 10a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (357 aa)
	LOC109981112	ATP-binding cassette, sub-family A (ABC1), member 4b. (2215 aa)
	rbp1	Retinol binding protein 1, cellular, tandem duplicate 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	napepld	N-acyl phosphatidylethanolamine phospholipase D. (455 aa)
	stra6	Stimulated by retinoic acid 6. (656 aa)
	plekhd1	Pleckstrin homology domain containing, family D (with coiled-coil domains) member 1. (510 aa)
	LOC109986848	Retinaldehyde binding protein 1a. (312 aa)
	PTCHD3-2	Patched domain containing 3. (837 aa)
	LOC109980595	Retinol dehydrogenase 20; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
	LOC109988649	Uncharacterized protein. (627 aa)
	LOC109993945	Myosin VIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2159 aa)
	ptchd4	Patched domain containing 4. (911 aa)
	ENSLBEP00000038460	ATP-binding cassette, sub-family A (ABC1), member 4a. (826 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000006166	LOC109993409	ENSLBEP00000006166	ENSLBEP00000000627	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.409
ENSLBEP00000006251	LOC109993409	ENSLBEP00000006251	ENSLBEP00000000627	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.409
ENSLBEP00000011867	LOC109992289	ENSLBEP00000011867	ENSLBEP00000000679	Rhodopsin.	Retinol binding protein 3.	0.524
ENSLBEP00000011867	LOC109997406	ENSLBEP00000011867	ENSLBEP00000000730	Rhodopsin.	Rhodopsin.	0.819
ENSLBEP00000011867	LOC110002300	ENSLBEP00000011867	ENSLBEP00000004117	Rhodopsin.	Rhodopsin.	0.819
ENSLBEP00000011867	LOC110002301	ENSLBEP00000011867	ENSLBEP00000004081	Rhodopsin.	Rhodopsin.	0.819
ENSLBEP00000011867	LOC110002302	ENSLBEP00000011867	ENSLBEP00000004153	Rhodopsin.	Rhodopsin.	0.819
ENSLBEP00000011867	RHO	ENSLBEP00000011867	ENSLBEP00000007083	Rhodopsin.	Extra-ocular rhodopsin.	0.856
ENSLBEP00000011867	rbp3	ENSLBEP00000011867	ENSLBEP00000000676	Rhodopsin.	Interphotoreceptor retinoid-binding protein like.	0.524
ENSLBEP00000013509	LOC109993409	ENSLBEP00000013509	ENSLBEP00000000627	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.409
ENSLBEP00000016937	LOC109993409	ENSLBEP00000016937	ENSLBEP00000000627	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.409
LOC109976169	LOC109980595	ENSLBEP00000012348	ENSLBEP00000026598	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol dehydrogenase 20; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.523
LOC109976169	LOC109980857	ENSLBEP00000012348	ENSLBEP00000005830	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol dehydrogenase 5 (11-cis/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.835
LOC109976169	LOC109986569	ENSLBEP00000012348	ENSLBEP00000005604	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinoid isomerohydrolase RPE65 b.	0.575
LOC109976169	LOC109988252	ENSLBEP00000012348	ENSLBEP00000004025	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cytochrome P450, family 4, subfamily V, polypeptide 8; Belongs to the cytochrome P450 family.	0.460
LOC109976169	LOC109988302	ENSLBEP00000012348	ENSLBEP00000004541	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	LRAT domain-containing protein.	0.856
LOC109976169	LOC109990122	ENSLBEP00000012348	ENSLBEP00000015879	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.523
LOC109976169	LOC109991778	ENSLBEP00000012348	ENSLBEP00000005827	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.512
LOC109976169	LOC109991786	ENSLBEP00000012348	ENSLBEP00000005845	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.512
LOC109976169	LOC109992372	ENSLBEP00000012348	ENSLBEP00000012926	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.549