(25 nodes) FRS-mediated FGFR3 signaling network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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gene fusions

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Your Input:
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
	LOC109982371	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	LOC109990363	Fibroblast growth factor receptor substrate 3. (619 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	grb2	Growth factor receptor bound protein 2. (230 aa)
	LOC109981096	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	LOC109987197	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (869 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (488 aa)
	LOC110006097	Fibroblast growth factor receptor substrate 2b. (509 aa)
	ENSLBEP00000001811	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC109999905	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC110004432	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC109994508	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (153 aa)
	LOC110001409	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (153 aa)
	LOC109996736	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	LOC109998395	Zgc:55558. (187 aa)
	LOC109985155	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC109976595	Uncharacterized protein. (221 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSLBEP00000001811	ENSLBEP00000019296	ENSLBEP00000001811	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.582
CSDE1	FRS2	ENSLBEP00000019296	ENSLBEP00000017083	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2.	0.540
CSDE1	LOC109976595	ENSLBEP00000019296	ENSLBEP00000028315	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.755
CSDE1	LOC109981096	ENSLBEP00000019296	ENSLBEP00000021415	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	LOC109982371	ENSLBEP00000019296	ENSLBEP00000026874	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
CSDE1	LOC109985155	ENSLBEP00000019296	ENSLBEP00000028869	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
CSDE1	LOC109987197	ENSLBEP00000019296	ENSLBEP00000020274	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
CSDE1	LOC109990363	ENSLBEP00000019296	ENSLBEP00000026597	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.540
CSDE1	LOC109994508	ENSLBEP00000019296	ENSLBEP00000035653	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.529
CSDE1	LOC109996736	ENSLBEP00000019296	ENSLBEP00000032847	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
CSDE1	LOC109999905	ENSLBEP00000019296	ENSLBEP00000009403	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.582
CSDE1	LOC110001409	ENSLBEP00000019296	ENSLBEP00000035595	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	LOC110004432	ENSLBEP00000019296	ENSLBEP00000010018	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
CSDE1	LOC110006097	ENSLBEP00000019296	ENSLBEP00000010295	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.540
CSDE1	fgf1	ENSLBEP00000019296	ENSLBEP00000033953	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.529
CSDE1	fgf16	ENSLBEP00000019296	ENSLBEP00000035270	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	fgf17	ENSLBEP00000019296	ENSLBEP00000001899	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.547
CSDE1	fgf23	ENSLBEP00000019296	ENSLBEP00000013352	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.589
CSDE1	fgf5	ENSLBEP00000019296	ENSLBEP00000024018	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
CSDE1	grb2	ENSLBEP00000019296	ENSLBEP00000022583	Cold shock domain containing E1, RNA-binding.	Growth factor receptor bound protein 2.	0.757