(29 nodes) Translesion synthesis by POLK network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	meiob	Methionine sulfoxide reductase B1b. (438 aa)
	rev1	REV1 DNA directed polymerase. (1385 aa)
	LOC109978538	RCC1 and BTB domain containing protein 1. (531 aa)
	ubb	Ubiquitin B. (759 aa)
	kxd1	KxDL motif containing 1. (185 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rfc2	Replication factor C (activator 1) 2. (233 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (2789 aa)
	ENSLBEP00000011876	Uncharacterized protein. (726 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	ENSLBEP00000005965	RFC1 domain-containing protein. (117 aa)
	rfc1	Replication factor C subunit 1. (1024 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (705 aa)
	LOC109993446	AAA domain-containing protein. (835 aa)
	LOC109987076	RPA_C domain-containing protein. (257 aa)
	ENSLBEP00000000800	Uncharacterized protein. (66 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1-like. (531 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (210 aa)
	ENSLBEP00000026818	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (474 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (605 aa)
	polk	Polymerase (DNA directed) kappa. (395 aa)
	LOC109975370	Uncharacterized protein. (330 aa)
	rpa2	Replication protein A2. (274 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	rpa3	Replication protein A3. (122 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000800	ENSLBEP00000005965	ENSLBEP00000000800	ENSLBEP00000005965	Uncharacterized protein.	RFC1 domain-containing protein.	0.947
ENSLBEP00000000800	ENSLBEP00000011876	ENSLBEP00000000800	ENSLBEP00000011876	Uncharacterized protein.	Uncharacterized protein.	0.947
ENSLBEP00000000800	LOC109975370	ENSLBEP00000000800	ENSLBEP00000030716	Uncharacterized protein.	Uncharacterized protein.	0.947
ENSLBEP00000000800	LOC109987076	ENSLBEP00000000800	ENSLBEP00000001241	Uncharacterized protein.	RPA_C domain-containing protein.	0.807
ENSLBEP00000000800	LOC109993446	ENSLBEP00000000800	ENSLBEP00000002521	Uncharacterized protein.	AAA domain-containing protein.	0.947
ENSLBEP00000000800	RPA1	ENSLBEP00000000800	ENSLBEP00000002897	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.869
ENSLBEP00000000800	mad2l2	ENSLBEP00000000800	ENSLBEP00000025152	Uncharacterized protein.	Mitotic arrest deficient 2 like 2.	0.757
ENSLBEP00000000800	meiob	ENSLBEP00000000800	ENSLBEP00000032513	Uncharacterized protein.	Methionine sulfoxide reductase B1b.	0.869
ENSLBEP00000000800	pcna	ENSLBEP00000000800	ENSLBEP00000019477	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.993
ENSLBEP00000000800	polk	ENSLBEP00000000800	ENSLBEP00000028598	Uncharacterized protein.	Polymerase (DNA directed) kappa.	0.737
ENSLBEP00000000800	rev1	ENSLBEP00000000800	ENSLBEP00000024079	Uncharacterized protein.	REV1 DNA directed polymerase.	0.738
ENSLBEP00000000800	rev3l	ENSLBEP00000000800	ENSLBEP00000015112	Uncharacterized protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.819
ENSLBEP00000000800	rfc1	ENSLBEP00000000800	ENSLBEP00000005377	Uncharacterized protein.	Replication factor C subunit 1.	0.947
ENSLBEP00000000800	rfc3	ENSLBEP00000000800	ENSLBEP00000004391	Uncharacterized protein.	Replication factor C (activator 1) 3.	0.996
ENSLBEP00000000800	rfc4	ENSLBEP00000000800	ENSLBEP00000000728	Uncharacterized protein.	Replication factor C (activator 1) 4.	0.996
ENSLBEP00000000800	rfc5	ENSLBEP00000000800	ENSLBEP00000011423	Uncharacterized protein.	Replication factor C (activator 1) 5.	0.996
ENSLBEP00000000800	rpa1	ENSLBEP00000000800	ENSLBEP00000028522	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.869
ENSLBEP00000000800	rpa2	ENSLBEP00000000800	ENSLBEP00000036934	Uncharacterized protein.	Replication protein A2.	0.807
ENSLBEP00000000800	rpa3	ENSLBEP00000000800	ENSLBEP00000037336	Uncharacterized protein.	Replication protein A3.	0.842
ENSLBEP00000000800	rps27a	ENSLBEP00000000800	ENSLBEP00000000668	Uncharacterized protein.	Ribosomal protein S27a.	0.702