STRINGSTRING
LOC109985734 LOC109985734 rpa3 rpa3 kxd1 kxd1 LOC109981032 LOC109981032 ENSLBEP00000019997 ENSLBEP00000019997 ENSLBEP00000019793 ENSLBEP00000019793 eya1 eya1 pcna pcna ENSLBEP00000019134 ENSLBEP00000019134 ENSLBEP00000019089 ENSLBEP00000019089 lig4 lig4 ENSLBEP00000018855 ENSLBEP00000018855 ENSLBEP00000018598 ENSLBEP00000018598 ankrd12 ankrd12 ENSLBEP00000018281 ENSLBEP00000018281 LOC109975983-3 LOC109975983-3 ENSLBEP00000018225 ENSLBEP00000018225 ENSLBEP00000018170 ENSLBEP00000018170 eme2 eme2 ENSLBEP00000018008 ENSLBEP00000018008 ENSLBEP00000017598 ENSLBEP00000017598 ENSLBEP00000017535 ENSLBEP00000017535 LOC110005835 LOC110005835 rfc2 rfc2 parp1 parp1 SMARCA1 SMARCA1 pole pole ENSLBEP00000015855 ENSLBEP00000015855 LOC110000833 LOC110000833 atm atm ENSLBEP00000015699 ENSLBEP00000015699 LOC109975983-2 LOC109975983-2 topbp1 topbp1 nhej1 nhej1 parp3 parp3 KPNA2 KPNA2 ENSLBEP00000000205 ENSLBEP00000000205 ENSLBEP00000000332 ENSLBEP00000000332 rps27a rps27a rfc4 rfc4 pold3 pold3 ube2v2 ube2v2 LOC109987076 LOC109987076 sirt6 sirt6 ENSLBEP00000001763 ENSLBEP00000001763 ENSLBEP00000001874 ENSLBEP00000001874 pole2 pole2 rmi1 rmi1 ENSLBEP00000002444 ENSLBEP00000002444 ENSLBEP00000002749 ENSLBEP00000002749 LOC109984746 LOC109984746 RPA1 RPA1 ENSLBEP00000003165 ENSLBEP00000003165 eya4 eya4 xrcc6 xrcc6 polh polh ENSLBEP00000003618 ENSLBEP00000003618 ENSLBEP00000004009 ENSLBEP00000004009 ankrd11 ankrd11 xrcc5 xrcc5 rfc3 rfc3 LOC114920595 LOC114920595 ENSLBEP00000004684 ENSLBEP00000004684 ENSLBEP00000004710 ENSLBEP00000004710 apbb1 apbb1 rfc1 rfc1 ENSLBEP00000005965 ENSLBEP00000005965 LOC109980809 LOC109980809 ENSLBEP00000006293 ENSLBEP00000006293 parp2 parp2 dntt dntt brca1 brca1 LOC110001535 LOC110001535 LOC110002821 LOC110002821 ENSLBEP00000007283 ENSLBEP00000007283 ENSLBEP00000007408 ENSLBEP00000007408 LOC109995824 LOC109995824 ENSLBEP00000007592 ENSLBEP00000007592 ENSLBEP00000007755 ENSLBEP00000007755 xrcc4 xrcc4 LOC109976453 LOC109976453 ENSLBEP00000008223 ENSLBEP00000008223 ENSLBEP00000008291 ENSLBEP00000008291 ENSLBEP00000008332 ENSLBEP00000008332 ENSLBEP00000008381 ENSLBEP00000008381 pole4 pole4 LOC109976453-2 LOC109976453-2 LOC109975983 LOC109975983 LOC109984173 LOC109984173 ENSLBEP00000009388 ENSLBEP00000009388 LOC109996043 LOC109996043 LOC110003678 LOC110003678 ENSLBEP00000010136 ENSLBEP00000010136 LOC109978025 LOC109978025 ENSLBEP00000010300 ENSLBEP00000010300 ppp4r2 ppp4r2 ENSLBEP00000010998 ENSLBEP00000010998 ENSLBEP00000011131 ENSLBEP00000011131 ENSLBEP00000011211 ENSLBEP00000011211 rfc5 rfc5 dna2 dna2 LOC109977673 LOC109977673 LOC109995863 LOC109995863 ENSLBEP00000011792 ENSLBEP00000011792 rad9a rad9a PPP5C PPP5C ENSLBEP00000012461 ENSLBEP00000012461 poll poll sirt7 sirt7 ENSLBEP00000012771 ENSLBEP00000012771 LOC109975730 LOC109975730 ENSLBEP00000013081 ENSLBEP00000013081 ENSLBEP00000013333 ENSLBEP00000013333 rad51ap1 rad51ap1 rnf8 rnf8 rad17 rad17 LOC109996986 LOC109996986 ENSLBEP00000013814 ENSLBEP00000013814 LOC109983175 LOC109983175 ENSLBEP00000014204 ENSLBEP00000014204 ENSLBEP00000014327 ENSLBEP00000014327 ENSLBEP00000014692 ENSLBEP00000014692 sumo1 sumo1 ENSLBEP00000014939 ENSLBEP00000014939 tdrd3 tdrd3 rcbtb2 rcbtb2 LOC110002044 LOC110002044 uba52 uba52 rpa2 rpa2 tp53 tp53 LOC109988927 LOC109988927 sumo2 sumo2 baz1b baz1b babam1 babam1 rad51d rad51d lig3 lig3 ENSLBEP00000034610 ENSLBEP00000034610 rhno1 rhno1 rad51 rad51 mre11 mre11 LOC114921852 LOC114921852 ENSLBEP00000033968 ENSLBEP00000033968 ENSLBEP00000033924 ENSLBEP00000033924 atrip atrip rad50 rad50 cnppd1 cnppd1 ENSLBEP00000033020 ENSLBEP00000033020 ENSLBEP00000033002 ENSLBEP00000033002 fen1 fen1 ENSLBEP00000032910 ENSLBEP00000032910 ENSLBEP00000032858 ENSLBEP00000032858 ENSLBEP00000032736 ENSLBEP00000032736 kat5 kat5 xrcc1 xrcc1 ENSLBEP00000032677 ENSLBEP00000032677 ENSLBEP00000032594 ENSLBEP00000032594 meiob meiob LOC110003393 LOC110003393 exo1 exo1 LOC109975983-6 LOC109975983-6 ENSLBEP00000032296 ENSLBEP00000032296 LOC110003388 LOC110003388 xrcc2 xrcc2 rmi2 rmi2 pold1 pold1 ENSLBEP00000030915 ENSLBEP00000030915 LOC109975370 LOC109975370 rif1 rif1 ENSLBEP00000030671 ENSLBEP00000030671 babam2 babam2 ENSLBEP00000030621 ENSLBEP00000030621 LOC110001276 LOC110001276 LOC109987419 LOC109987419 ENSLBEP00000030418 ENSLBEP00000030418 ENSLBEP00000030415 ENSLBEP00000030415 LOC109975983-5 LOC109975983-5 pold2 pold2 LOC109975983-4 LOC109975983-4 ENSLBEP00000029834 ENSLBEP00000029834 ENSLBEP00000029632 ENSLBEP00000029632 dclre1c dclre1c polm polm ENSLBEP00000028846 ENSLBEP00000028846 polk polk rpa1 rpa1 LOC109989703 LOC109989703 hus1 hus1 ccna1 ccna1 LOC109997178 LOC109997178 ENSLBEP00000037734 ENSLBEP00000037734 ENSLBEP00000026818 ENSLBEP00000026818 ENSLBEP00000026682 ENSLBEP00000026682 ENSLBEP00000026408 ENSLBEP00000026408 ENSLBEP00000026317 ENSLBEP00000026317 LOC109986892 LOC109986892 LOC109976496 LOC109976496 ENSLBEP00000026111 ENSLBEP00000026111 LOC109998305 LOC109998305 ENSLBEP00000025814 ENSLBEP00000025814 LOC109976454 LOC109976454 pold4 pold4 tipin tipin ENSLBEP00000025525 ENSLBEP00000025525 ENSLBEP00000025489 ENSLBEP00000025489 abl1 abl1 RCBTB1 RCBTB1 abraxas1 abraxas1 tdp2 tdp2 blm blm ENSLBEP00000024280 ENSLBEP00000024280 ENSLBEP00000024266 ENSLBEP00000024266 top3a top3a LOC109978538 LOC109978538 ENSLBEP00000023799 ENSLBEP00000023799 pias4 pias4 smarca5 smarca5 rad1 rad1 paxip1 paxip1 ENSLBEP00000023301 ENSLBEP00000023301 LOC109994882 LOC109994882 LOC109995474 LOC109995474 eya3 eya3 LOC110002533 LOC110002533 ENSLBEP00000022186 ENSLBEP00000022186 LOC109975980 LOC109975980 ENSLBEP00000021906 ENSLBEP00000021906 LOC109976362 LOC109976362 tp53bp1 tp53bp1 timeless timeless LOC109976346 LOC109976346 ube2i ube2i ubb ubb ENSLBEP00000021185 ENSLBEP00000021185 LOC109998245 LOC109998245 cdk2 cdk2 LOC109984378 LOC109984378 mus81 mus81 ENSLBEP00000020673 ENSLBEP00000020673 chek1 chek1 uimc1 uimc1 spidr spidr ENSLBEP00000038853 ENSLBEP00000038853 ENSLBEP00000038843 ENSLBEP00000038843 LOC109992673 LOC109992673 LOC109987635 LOC109987635 ppp4c ppp4c LOC110002098 LOC110002098 atr atr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC109985734Histone H2A; Belongs to the histone H2A family. (135 aa)
rpa3Replication protein A3. (122 aa)
kxd1KxDL motif containing 1. (185 aa)
LOC109981032Uncharacterized protein. (251 aa)
ENSLBEP00000019997UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa)
ENSLBEP00000019793annotation not available (952 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSLBEP00000019134Chromo_2 domain-containing protein. (634 aa)
ENSLBEP00000019089Uncharacterized protein. (202 aa)
lig4DNA ligase. (827 aa)
ENSLBEP00000018855SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1204 aa)
ENSLBEP00000018598annotation not available (952 aa)
ankrd12Ankyrin repeat domain 12. (1951 aa)
ENSLBEP00000018281Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC109975983-3Histone H4. (103 aa)
ENSLBEP00000018225annotation not available (170 aa)
ENSLBEP00000018170Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
eme2ERCC4 domain-containing protein. (531 aa)
ENSLBEP00000018008annotation not available (67 aa)
ENSLBEP00000017598Reverse transcriptase domain-containing protein. (278 aa)
ENSLBEP00000017535Reverse transcriptase domain-containing protein. (928 aa)
LOC110005835Importin subunit alpha; Belongs to the importin alpha family. (519 aa)
rfc2Replication factor C (activator 1) 2. (233 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (985 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
ENSLBEP00000015855BRCA1/BRCA2-containing complex, subunit 3. (261 aa)
LOC110000833Histone H2B; Belongs to the histone H2B family. (122 aa)
atmNon-specific serine/threonine protein kinase. (3019 aa)
ENSLBEP00000015699annotation not available (1323 aa)
LOC109975983-2Histone H4. (103 aa)
topbp1DNA topoisomerase II binding protein 1. (1444 aa)
nhej1Nonhomologous end-joining factor 1. (316 aa)
parp3Poly [ADP-ribose] polymerase. (527 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (523 aa)
ENSLBEP00000000205Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (147 aa)
ENSLBEP00000000332Histone H2B; Belongs to the histone H2B family. (114 aa)
rps27aRibosomal protein S27a. (156 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (154 aa)
LOC109987076RPA_C domain-containing protein. (257 aa)
sirt6Sirtuin 6. (351 aa)
ENSLBEP00000001763Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSLBEP00000001874RAD9 checkpoint clamp component B. (188 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (496 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (657 aa)
ENSLBEP00000002444Uncharacterized protein. (289 aa)
ENSLBEP00000002749Uncharacterized protein. (926 aa)
LOC109984746Tower domain-containing protein. (922 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (705 aa)
ENSLBEP00000003165Uncharacterized protein. (1068 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (610 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (619 aa)
polhPolymerase (DNA directed), eta. (723 aa)
ENSLBEP00000003618UBIQUITIN_CONJUGAT_2 domain-containing protein. (114 aa)
ENSLBEP00000004009Histone H2B; Belongs to the histone H2B family. (123 aa)
ankrd11Ankyrin repeat domain 11. (2723 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (724 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC114920595ANK_REP_REGION domain-containing protein. (684 aa)
ENSLBEP00000004684Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSLBEP00000004710Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (161 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (684 aa)
rfc1Replication factor C subunit 1. (1024 aa)
ENSLBEP00000005965RFC1 domain-containing protein. (117 aa)
LOC109980809Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
ENSLBEP00000006293Uncharacterized protein. (166 aa)
parp2Poly [ADP-ribose] polymerase. (551 aa)
dnttDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (497 aa)
brca1Uncharacterized protein. (1180 aa)
LOC110001535CBFD_NFYB_HMF domain-containing protein. (153 aa)
LOC110002821Small ubiquitin-related modifier. (96 aa)
ENSLBEP00000007283Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSLBEP00000007408Histone H2B; Belongs to the histone H2B family. (117 aa)
LOC109995824Uncharacterized protein. (1402 aa)
ENSLBEP00000007592Ubiquitin-like domain-containing protein. (93 aa)
ENSLBEP00000007755Histone H2B; Belongs to the histone H2B family. (123 aa)
xrcc4Uncharacterized protein. (314 aa)
LOC109976453Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSLBEP00000008223Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSLBEP00000008291Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSLBEP00000008332Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (84 aa)
ENSLBEP00000008381Histone H2B; Belongs to the histone H2B family. (118 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
LOC109976453-2Histone H2B-like. (122 aa)
LOC109975983Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC109984173Transmembrane protein 182b. (256 aa)
ENSLBEP00000009388Histone H2A; Belongs to the histone H2A family. (144 aa)
LOC109996043Zgc:110269. (347 aa)
LOC110003678Uncharacterized protein. (363 aa)
ENSLBEP00000010136Reverse transcriptase domain-containing protein. (1322 aa)
LOC109978025DNA polymerase epsilon subunit 3-like. (153 aa)
ENSLBEP00000010300Reverse transcriptase domain-containing protein. (1323 aa)
ppp4r2Uncharacterized protein. (294 aa)
ENSLBEP00000010998Reverse transcriptase domain-containing protein. (1323 aa)
ENSLBEP00000011131annotation not available (1027 aa)
ENSLBEP00000011211Reverse transcriptase domain-containing protein. (988 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
dna2DNA replication helicase/nuclease 2. (1384 aa)
LOC109977673UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
LOC109995863Uncharacterized protein. (555 aa)
ENSLBEP00000011792Uncharacterized protein. (142 aa)
rad9aRAD9 checkpoint clamp component A. (372 aa)
PPP5CSerine/threonine-protein phosphatase. (500 aa)
ENSLBEP00000012461Reverse transcriptase domain-containing protein. (952 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (568 aa)
sirt7Sirtuin 7. (406 aa)
ENSLBEP00000012771Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
LOC109975730RECA_2 domain-containing protein. (340 aa)
ENSLBEP00000013081Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSLBEP00000013333annotation not available (96 aa)
rad51ap1RAD51 associated protein 1. (323 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (525 aa)
rad17RAD17 checkpoint clamp loader component. (618 aa)
LOC109996986UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSLBEP00000013814FHA domain-containing protein. (1364 aa)
LOC109983175Protein phosphatase 4, regulatory subunit 2b. (424 aa)
ENSLBEP00000014204Reverse transcriptase domain-containing protein. (914 aa)
ENSLBEP00000014327Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (444 aa)
ENSLBEP00000014692Uncharacterized protein. (200 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
ENSLBEP00000014939Reverse transcriptase domain-containing protein. (949 aa)
tdrd3Tudor domain containing 3. (751 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
LOC110002044UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (273 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
rpa2Replication protein A2. (274 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (374 aa)
LOC109988927Essential meiotic structure-specific endonuclease 1. (521 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1593 aa)
babam1BRISC and BRCA1 A complex member 1. (378 aa)
rad51dRAD51 paralog D. (334 aa)
lig3DNA ligase. (1039 aa)
ENSLBEP00000034610Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
rhno1Si:ch73-352p4.5. (279 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (641 aa)
LOC114921852Histone H4-like. (79 aa)
ENSLBEP00000033968Histone H2B; Belongs to the histone H2B family. (132 aa)
ENSLBEP00000033924Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (143 aa)
atripUncharacterized protein. (832 aa)
rad50RAD50 homolog, double strand break repair protein. (1284 aa)
cnppd1Cyclin Pas1/PHO80 domain containing 1. (437 aa)
ENSLBEP00000033020Uncharacterized protein. (122 aa)
ENSLBEP00000033002annotation not available (117 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSLBEP00000032910Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (80 aa)
ENSLBEP00000032858annotation not available (117 aa)
ENSLBEP00000032736Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (625 aa)
ENSLBEP00000032677Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSLBEP00000032594annotation not available (93 aa)
meiobMethionine sulfoxide reductase B1b. (438 aa)
LOC110003393DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (334 aa)
exo1Exonuclease 1. (793 aa)
LOC109975983-6Histone H4. (103 aa)
ENSLBEP00000032296Histone H2B; Belongs to the histone H2B family. (118 aa)
LOC110003388Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (265 aa)
xrcc2RECA_2 domain-containing protein. (304 aa)
rmi2RecQ mediated genome instability 2. (144 aa)
pold1DNA polymerase. (1126 aa)
ENSLBEP00000030915annotation not available (117 aa)
LOC109975370Uncharacterized protein. (330 aa)
rif1Replication timing regulatory factor 1. (2650 aa)
ENSLBEP00000030671annotation not available (93 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
ENSLBEP00000030621annotation not available (67 aa)
LOC110001276Importin subunit alpha; Belongs to the importin alpha family. (523 aa)
LOC109987419Histone H2B-like. (122 aa)
ENSLBEP00000030418Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (152 aa)
ENSLBEP00000030415Reverse transcriptase domain-containing protein. (823 aa)
LOC109975983-5Histone H4. (103 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
LOC109975983-4Histone H4. (103 aa)
ENSLBEP00000029834Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSLBEP00000029632Uncharacterized protein. (193 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (671 aa)
polmDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (533 aa)
ENSLBEP00000028846Abraxas 1, BRCA1 A complex subunit. (337 aa)
polkPolymerase (DNA directed) kappa. (395 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (605 aa)
LOC109989703Uncharacterized protein. (905 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (393 aa)
LOC109997178Small ubiquitin-related modifier. (95 aa)
ENSLBEP00000037734SAE2 domain-containing protein. (93 aa)
ENSLBEP00000026818Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (474 aa)
ENSLBEP00000026682Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSLBEP00000026408Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSLBEP00000026317Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
LOC109986892Histone H2B; Belongs to the histone H2B family. (132 aa)
LOC109976496Uncharacterized protein. (470 aa)
ENSLBEP00000026111Histone H2B; Belongs to the histone H2B family. (114 aa)
LOC109998305Small ubiquitin-related modifier. (94 aa)
ENSLBEP00000025814Uncharacterized protein. (154 aa)
LOC109976454Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
pold4Si:dkey-28b4.7. (111 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (334 aa)
ENSLBEP00000025525Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSLBEP00000025489Histone H2B; Belongs to the histone H2B family. (117 aa)
abl1Tyrosine-protein kinase. (1132 aa)
RCBTB1RCC1 and BTB domain-containing protein 1-like. (531 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (371 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (360 aa)
blmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (846 aa)
ENSLBEP00000024280ANK_REP_REGION domain-containing protein. (346 aa)
ENSLBEP00000024266Uncharacterized protein. (200 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1018 aa)
LOC109978538RCC1 and BTB domain containing protein 1. (531 aa)
ENSLBEP00000023799annotation not available (298 aa)
pias4Protein inhibitor of activated STAT, 4a. (507 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1034 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
paxip1PAX interacting (with transcription-activation domain) protein 1. (1141 aa)
ENSLBEP00000023301Reverse transcriptase domain-containing protein. (796 aa)
LOC109994882Transmembrane protein 182a. (241 aa)
LOC109995474Serine/threonine-protein phosphatase 5. (500 aa)
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (606 aa)
LOC110002533RECA_2 domain-containing protein. (354 aa)
ENSLBEP00000022186annotation not available (95 aa)
LOC109975980Uncharacterized protein; Belongs to the histone H2B family. (79 aa)
ENSLBEP00000021906annotation not available (952 aa)
LOC109976362RAD51 paralog C. (342 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1256 aa)
timelessTimeless circadian clock. (1235 aa)
LOC109976346Histone H2B-like. (122 aa)
ube2iUbiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ubbUbiquitin B. (759 aa)
ENSLBEP00000021185annotation not available (95 aa)
LOC109998245Cyclin A2; Belongs to the cyclin family. (441 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC109984378Cell division cycle associated 7a. (367 aa)
mus81MUS81 structure-specific endonuclease subunit. (496 aa)
ENSLBEP00000020673RecQ helicase-like 4. (781 aa)
chek1Checkpoint kinase 1. (504 aa)
uimc1RAP80_UIM domain-containing protein. (794 aa)
spidrUncharacterized protein. (933 aa)
ENSLBEP00000038853Reverse transcriptase domain-containing protein. (931 aa)
ENSLBEP00000038843Reverse transcriptase domain-containing protein. (1144 aa)
LOC109992673Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4073 aa)
LOC109987635UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
LOC110002098Exonuclease 3'-5' domain containing 2. (633 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2437 aa)
Your Current Organism:
Labrus bergylta
NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse
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