(35 nodes) Resolution of D-Loop Structures network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLBEP00000020673	RecQ helicase-like 4. (781 aa)
	LOC109976362	RAD51 paralog C. (342 aa)
	LOC110002533	RECA_2 domain-containing protein. (354 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1018 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (846 aa)
	rmi2	RecQ mediated genome instability 2. (144 aa)
	xrcc2	RECA_2 domain-containing protein. (304 aa)
	LOC110003388	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (265 aa)
	exo1	Exonuclease 1. (793 aa)
	LOC110003393	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (334 aa)
	rad51ap1	RAD51 associated protein 1. (323 aa)
	LOC109975730	RECA_2 domain-containing protein. (340 aa)
	dna2	DNA replication helicase/nuclease 2. (1384 aa)
	brca1	Uncharacterized protein. (1180 aa)
	LOC114920595	ANK_REP_REGION domain-containing protein. (684 aa)
	ankrd11	Ankyrin repeat domain 11. (2723 aa)
	LOC109984746	Tower domain-containing protein. (922 aa)
	ENSLBEP00000002749	Uncharacterized protein. (926 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (657 aa)
	kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1284 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (641 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	rad51d	RAD51 paralog D. (334 aa)
	LOC109988927	Essential meiotic structure-specific endonuclease 1. (521 aa)
	spidr	Uncharacterized protein. (933 aa)
	atm	Non-specific serine/threonine protein kinase. (3019 aa)
	eme2	ERCC4 domain-containing protein. (531 aa)
	ankrd12	Ankyrin repeat domain 12. (1951 aa)
	ENSLBEP00000018855	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1204 aa)
	ENSLBEP00000019089	Uncharacterized protein. (202 aa)
	ENSLBEP00000019134	Chromo_2 domain-containing protein. (634 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (496 aa)
	ENSLBEP00000037734	SAE2 domain-containing protein. (93 aa)
	ENSLBEP00000014327	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (444 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000002749	ENSLBEP00000014327	ENSLBEP00000002749	ENSLBEP00000014327	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.454
ENSLBEP00000002749	ENSLBEP00000018855	ENSLBEP00000002749	ENSLBEP00000018855	Uncharacterized protein.	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).	0.772
ENSLBEP00000002749	ENSLBEP00000019089	ENSLBEP00000002749	ENSLBEP00000019089	Uncharacterized protein.	Uncharacterized protein.	0.613
ENSLBEP00000002749	ENSLBEP00000019134	ENSLBEP00000002749	ENSLBEP00000019134	Uncharacterized protein.	Chromo_2 domain-containing protein.	0.613
ENSLBEP00000002749	ENSLBEP00000020673	ENSLBEP00000002749	ENSLBEP00000020673	Uncharacterized protein.	RecQ helicase-like 4.	0.807
ENSLBEP00000002749	ENSLBEP00000037734	ENSLBEP00000002749	ENSLBEP00000037734	Uncharacterized protein.	SAE2 domain-containing protein.	0.859
ENSLBEP00000002749	LOC109975730	ENSLBEP00000002749	ENSLBEP00000012822	Uncharacterized protein.	RECA_2 domain-containing protein.	0.931
ENSLBEP00000002749	LOC109976362	ENSLBEP00000002749	ENSLBEP00000021803	Uncharacterized protein.	RAD51 paralog C.	0.967
ENSLBEP00000002749	LOC109984746	ENSLBEP00000002749	ENSLBEP00000002832	Uncharacterized protein.	Tower domain-containing protein.	0.897
ENSLBEP00000002749	LOC109988927	ENSLBEP00000002749	ENSLBEP00000036808	Uncharacterized protein.	Essential meiotic structure-specific endonuclease 1.	0.757
ENSLBEP00000002749	LOC110002533	ENSLBEP00000002749	ENSLBEP00000022361	Uncharacterized protein.	RECA_2 domain-containing protein.	0.967
ENSLBEP00000002749	LOC110003388	ENSLBEP00000002749	ENSLBEP00000032155	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.698
ENSLBEP00000002749	LOC110003393	ENSLBEP00000002749	ENSLBEP00000032455	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.931
ENSLBEP00000002749	LOC114920595	ENSLBEP00000002749	ENSLBEP00000004672	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.816
ENSLBEP00000002749	ankrd11	ENSLBEP00000002749	ENSLBEP00000004127	Uncharacterized protein.	Ankyrin repeat domain 11.	0.816
ENSLBEP00000002749	ankrd12	ENSLBEP00000002749	ENSLBEP00000018343	Uncharacterized protein.	Ankyrin repeat domain 12.	0.816
ENSLBEP00000002749	atm	ENSLBEP00000002749	ENSLBEP00000015731	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.878
ENSLBEP00000002749	blm	ENSLBEP00000002749	ENSLBEP00000024461	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.847
ENSLBEP00000002749	brca1	ENSLBEP00000002749	ENSLBEP00000007044	Uncharacterized protein.	Uncharacterized protein.	0.991
ENSLBEP00000002749	dna2	ENSLBEP00000002749	ENSLBEP00000011436	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.834