(9 nodes) IRS activation network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109981109	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	grb10	Growth factor receptor-bound protein 10b. (563 aa)
	LOC109990889	Growth factor receptor-bound protein 10a. (592 aa)
	LOC110003847	Insulin receptor substrate 2b. (1059 aa)
	LOC109995271	Preproinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (121 aa)
	insr	Tyrosine-protein kinase receptor. (1364 aa)
	LOC110006110	Insulin-like. (121 aa)
	LOC109996569	Insulin receptor substrate 2a. (1029 aa)
	LOC109987794	Tyrosine-protein kinase receptor. (1276 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC109981109	LOC109987794	ENSLBEP00000018238	ENSLBEP00000007125	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.950
LOC109981109	LOC109990889	ENSLBEP00000018238	ENSLBEP00000033082	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10a.	0.557
LOC109981109	LOC109995271	ENSLBEP00000018238	ENSLBEP00000007224	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Preproinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.725
LOC109981109	LOC109996569	ENSLBEP00000018238	ENSLBEP00000018984	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2a.	0.878
LOC109981109	LOC110003847	ENSLBEP00000018238	ENSLBEP00000024762	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2b.	0.878
LOC109981109	LOC110006110	ENSLBEP00000018238	ENSLBEP00000011075	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like.	0.725
LOC109981109	grb10	ENSLBEP00000018238	ENSLBEP00000037298	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10b.	0.557
LOC109981109	insr	ENSLBEP00000018238	ENSLBEP00000008641	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.950
LOC109987794	LOC109981109	ENSLBEP00000007125	ENSLBEP00000018238	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.950
LOC109987794	LOC109990889	ENSLBEP00000007125	ENSLBEP00000033082	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 10a.	0.934
LOC109987794	LOC109995271	ENSLBEP00000007125	ENSLBEP00000007224	Tyrosine-protein kinase receptor.	Preproinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.889
LOC109987794	LOC109996569	ENSLBEP00000007125	ENSLBEP00000018984	Tyrosine-protein kinase receptor.	Insulin receptor substrate 2a.	0.955
LOC109987794	LOC110003847	ENSLBEP00000007125	ENSLBEP00000024762	Tyrosine-protein kinase receptor.	Insulin receptor substrate 2b.	0.955
LOC109987794	LOC110006110	ENSLBEP00000007125	ENSLBEP00000011075	Tyrosine-protein kinase receptor.	Insulin-like.	0.889
LOC109987794	grb10	ENSLBEP00000007125	ENSLBEP00000037298	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 10b.	0.934
LOC109990889	LOC109981109	ENSLBEP00000033082	ENSLBEP00000018238	Growth factor receptor-bound protein 10a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.557
LOC109990889	LOC109987794	ENSLBEP00000033082	ENSLBEP00000007125	Growth factor receptor-bound protein 10a.	Tyrosine-protein kinase receptor.	0.934
LOC109990889	LOC109995271	ENSLBEP00000033082	ENSLBEP00000007224	Growth factor receptor-bound protein 10a.	Preproinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.557
LOC109990889	LOC109996569	ENSLBEP00000033082	ENSLBEP00000018984	Growth factor receptor-bound protein 10a.	Insulin receptor substrate 2a.	0.502
LOC109990889	LOC110003847	ENSLBEP00000033082	ENSLBEP00000024762	Growth factor receptor-bound protein 10a.	Insulin receptor substrate 2b.	0.502