(20 nodes) VLDLR internalisation and degradation network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (227 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (662 aa)
	vldlr	Very low density lipoprotein receptor. (872 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
	LOC109975086	Alpha_adaptin_C domain-containing protein. (165 aa)
	ENSLBEP00000019627	Uncharacterized protein. (974 aa)
	kxd1	KxDL motif containing 1. (185 aa)
	LOC109991982	Clat_adaptor_s domain-containing protein. (146 aa)
	ubb	Ubiquitin B. (759 aa)
	ENSLBEP00000028622	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (927 aa)
	ENSLBEP00000028630	Adaptin_N domain-containing protein. (322 aa)
	mylip	Myosin regulatory light chain interacting protein a. (482 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (163 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSLBEP00000000711	TSNAXIP1_N domain-containing protein. (383 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC109979698	Clat_adaptor_s domain-containing protein. (120 aa)
	ap2a1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
	LOC109988911	AP complex subunit beta. (957 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000711	ENSLBEP00000019627	ENSLBEP00000000711	ENSLBEP00000019627	TSNAXIP1_N domain-containing protein.	Uncharacterized protein.	0.740
ENSLBEP00000000711	ENSLBEP00000028622	ENSLBEP00000000711	ENSLBEP00000028622	TSNAXIP1_N domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.584
ENSLBEP00000000711	ENSLBEP00000028630	ENSLBEP00000000711	ENSLBEP00000028630	TSNAXIP1_N domain-containing protein.	Adaptin_N domain-containing protein.	0.910
ENSLBEP00000000711	LOC109975086	ENSLBEP00000000711	ENSLBEP00000018586	TSNAXIP1_N domain-containing protein.	Alpha_adaptin_C domain-containing protein.	0.584
ENSLBEP00000000711	LOC109979698	ENSLBEP00000000711	ENSLBEP00000038711	TSNAXIP1_N domain-containing protein.	Clat_adaptor_s domain-containing protein.	0.765
ENSLBEP00000000711	LOC109988911	ENSLBEP00000000711	ENSLBEP00000010933	TSNAXIP1_N domain-containing protein.	AP complex subunit beta.	0.882
ENSLBEP00000000711	LOC109991982	ENSLBEP00000000711	ENSLBEP00000020393	TSNAXIP1_N domain-containing protein.	Clat_adaptor_s domain-containing protein.	0.740
ENSLBEP00000000711	ap2a1	ENSLBEP00000000711	ENSLBEP00000004011	TSNAXIP1_N domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.584
ENSLBEP00000000711	ap2m1	ENSLBEP00000000711	ENSLBEP00000016982	TSNAXIP1_N domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.740
ENSLBEP00000000711	ap2s1	ENSLBEP00000000711	ENSLBEP00000034963	TSNAXIP1_N domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.765
ENSLBEP00000000711	clta	ENSLBEP00000000711	ENSLBEP00000010919	TSNAXIP1_N domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.947
ENSLBEP00000000711	pcsk9	ENSLBEP00000000711	ENSLBEP00000013262	TSNAXIP1_N domain-containing protein.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.455
ENSLBEP00000000711	rps27a	ENSLBEP00000000711	ENSLBEP00000000668	TSNAXIP1_N domain-containing protein.	Ribosomal protein S27a.	0.678
ENSLBEP00000000711	ubb	ENSLBEP00000000711	ENSLBEP00000021236	TSNAXIP1_N domain-containing protein.	Ubiquitin B.	0.482
ENSLBEP00000019627	ENSLBEP00000000711	ENSLBEP00000019627	ENSLBEP00000000711	Uncharacterized protein.	TSNAXIP1_N domain-containing protein.	0.740
ENSLBEP00000019627	ENSLBEP00000028622	ENSLBEP00000019627	ENSLBEP00000028622	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.832
ENSLBEP00000019627	ENSLBEP00000028630	ENSLBEP00000019627	ENSLBEP00000028630	Uncharacterized protein.	Adaptin_N domain-containing protein.	0.994
ENSLBEP00000019627	LOC109975086	ENSLBEP00000019627	ENSLBEP00000018586	Uncharacterized protein.	Alpha_adaptin_C domain-containing protein.	0.832
ENSLBEP00000019627	LOC109979698	ENSLBEP00000019627	ENSLBEP00000038711	Uncharacterized protein.	Clat_adaptor_s domain-containing protein.	0.977
ENSLBEP00000019627	LOC109988911	ENSLBEP00000019627	ENSLBEP00000010933	Uncharacterized protein.	AP complex subunit beta.	0.934