(70 nodes) RHOD GTPase cycle network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109996791	VRK serine/threonine kinase 2. (579 aa)
	arhgap35	Uncharacterized protein. (1525 aa)
	CPNE8	Copine 8. (564 aa)
	LOC109988953	Uncharacterized protein. (637 aa)
	LOC110006100	Uncharacterized protein. (351 aa)
	pgrmc2	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (198 aa)
	arhgap5	Rho GTPase activating protein 5. (1488 aa)
	depdc1b	Rho-GAP domain-containing protein. (532 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (957 aa)
	diaph2	Diaphanous-related formin 2. (1147 aa)
	LOC109990492	Uncharacterized protein. (393 aa)
	cttnbp2	Cortactin binding protein 2. (1383 aa)
	LOC109981438	Rho GTPase activating protein 35b. (1529 aa)
	LOC109980843	VAMP (vesicle-associated membrane protein)-associated protein B and C. (239 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	LOC109980827	RAB7a, member RAS oncogene family. (207 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (275 aa)
	LOC109994558	Uncharacterized protein. (539 aa)
	lemd3	LEM domain containing 3. (841 aa)
	CPNE9	Copine family member 9. (511 aa)
	LOC109991630	Histidine triad nucleotide binding protein 2. (152 aa)
	LOC109985891	Rho GTPase activating protein 17b. (523 aa)
	LOC109981383	Non-specific serine/threonine protein kinase. (696 aa)
	pak5	Non-specific serine/threonine protein kinase. (741 aa)
	LOC109990419	Rho GTPase activating protein 17. (886 aa)
	WHAMM	WASP homolog associated with actin, golgi membranes and microtubules. (736 aa)
	lmnb1	Lamin B1; Belongs to the intermediate filament family. (579 aa)
	LOC110000807	Filamin A interacting protein 1b. (1164 aa)
	LOC109997231	CTTNBP2 N-terminal like a. (574 aa)
	stbd1	CBM20 domain-containing protein. (1276 aa)
	mospd2	Motile sperm domain containing 2. (559 aa)
	LOC109981150	Ras homolog family member F. (207 aa)
	ENSLBEP00000025988	Rho-GAP domain-containing protein. (181 aa)
	LOC109985834	Rho GTPase activating protein 21b. (1737 aa)
	LOC110001861	C2 domain-containing protein. (486 aa)
	cttnbp2nl	CTTNBP2 N-terminal like b. (593 aa)
	arhgap1	Uncharacterized protein. (430 aa)
	akap12	A kinase (PRKA) anchor protein 12b. (1472 aa)
	LOC109975248	Uncharacterized protein. (525 aa)
	golga2	Golgin A2. (1107 aa)
	ENSLBEP00000024171	Uncharacterized protein. (322 aa)
	ENSLBEP00000024149	Uncharacterized protein. (253 aa)
	ENSLBEP00000023797	Extended synaptotagmin-like protein 1b. (1058 aa)
	LOC109993753	Uncharacterized protein. (207 aa)
	LOC110003032	Non-specific serine/threonine protein kinase. (604 aa)
	lman1	Lectin, mannose-binding, 1. (518 aa)
	LOC109983866	Zgc:92107. (939 aa)
	racgap1	Rac GTPase activating protein 1. (631 aa)
	LOC109976316	Uncharacterized protein. (632 aa)
	VANGL1	Vang-like protein. (536 aa)
	LOC109994783	Copine Va. (573 aa)
	arhgap39	Rho GTPase activating protein 39. (1063 aa)
	EFHD1	EF-hand domain family member D1. (126 aa)
	LOC109990716	EF-hand domain family, member D1. (234 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC109990113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	efhd2	EF-hand domain family, member D2. (233 aa)
	ENSLBEP00000015241	Extended synaptotagmin-like protein 1a. (756 aa)
	ENSLBEP00000015189	Diaphanous-related formin 3. (360 aa)
	DIAPH1	Diaphanous related formin 1. (726 aa)
	ENSLBEP00000015139	Uncharacterized protein. (113 aa)
	vamp3	V-SNARE coiled-coil homology domain-containing protein. (136 aa)
	LOC109999396	LEM domain-containing protein. (79 aa)
	LOC109995954	Filamin A interacting protein 1a. (1198 aa)
	LOC110000554	Si:ch1073-416j23.1. (624 aa)
	LOC109984271	Copine Vb. (580 aa)
	pak4	Non-specific serine/threonine protein kinase. (658 aa)
	ENSLBEP00000013020	RNA binding motif protein 39b. (366 aa)
	arhgap21	Rho GTPase activating protein 21a. (1869 aa)
	LOC109981556	Copine family member IX. (545 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPNE8	capzb	ENSLBEP00000038420	ENSLBEP00000000964	Copine 8.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.495
CPNE8	vamp3	ENSLBEP00000038420	ENSLBEP00000015106	Copine 8.	V-SNARE coiled-coil homology domain-containing protein.	0.503
CPNE9	capzb	ENSLBEP00000038212	ENSLBEP00000000964	Copine family member 9.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.495
CPNE9	vamp3	ENSLBEP00000038212	ENSLBEP00000015106	Copine family member 9.	V-SNARE coiled-coil homology domain-containing protein.	0.503
DIAPH1	ENSLBEP00000015189	ENSLBEP00000015167	ENSLBEP00000015189	Diaphanous related formin 1.	Diaphanous-related formin 3.	0.961
DIAPH1	LOC109980827	ENSLBEP00000015167	ENSLBEP00000002268	Diaphanous related formin 1.	RAB7a, member RAS oncogene family.	0.417
DIAPH1	LOC109981150	ENSLBEP00000015167	ENSLBEP00000026508	Diaphanous related formin 1.	Ras homolog family member F.	0.793
DIAPH1	LOC109983866	ENSLBEP00000015167	ENSLBEP00000022282	Diaphanous related formin 1.	Zgc:92107.	0.511
DIAPH1	LOC109990492	ENSLBEP00000015167	ENSLBEP00000005123	Diaphanous related formin 1.	Uncharacterized protein.	0.918
DIAPH1	LOC109993753	ENSLBEP00000015167	ENSLBEP00000023215	Diaphanous related formin 1.	Uncharacterized protein.	0.417
DIAPH1	ankfy1	ENSLBEP00000015167	ENSLBEP00000006704	Diaphanous related formin 1.	Ankyrin repeat and FYVE domain containing 1.	0.583
DIAPH1	arhgap1	ENSLBEP00000015167	ENSLBEP00000025208	Diaphanous related formin 1.	Uncharacterized protein.	0.634
DIAPH1	arhgap39	ENSLBEP00000015167	ENSLBEP00000018921	Diaphanous related formin 1.	Rho GTPase activating protein 39.	0.511
DIAPH1	capzb	ENSLBEP00000015167	ENSLBEP00000000964	Diaphanous related formin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.570
EFHD1	LOC109980827	ENSLBEP00000018472	ENSLBEP00000002268	EF-hand domain family member D1.	RAB7a, member RAS oncogene family.	0.409
EFHD1	LOC109981150	ENSLBEP00000018472	ENSLBEP00000026508	EF-hand domain family member D1.	Ras homolog family member F.	0.512
EFHD1	LOC109993753	ENSLBEP00000018472	ENSLBEP00000023215	EF-hand domain family member D1.	Uncharacterized protein.	0.409
EFHD1	capzb	ENSLBEP00000018472	ENSLBEP00000000964	EF-hand domain family member D1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.746
EFHD1	vamp3	ENSLBEP00000018472	ENSLBEP00000015106	EF-hand domain family member D1.	V-SNARE coiled-coil homology domain-containing protein.	0.483
ENSLBEP00000013020	LOC109981150	ENSLBEP00000013020	ENSLBEP00000026508	RNA binding motif protein 39b.	Ras homolog family member F.	0.496