(101 nodes) RHOQ GTPase cycle network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK3	Non-specific serine/threonine protein kinase. (574 aa)
	gopc	Golgi-associated PDZ and coiled-coil motif containing. (429 aa)
	LOC109980827	RAB7a, member RAS oncogene family. (207 aa)
	LOC109991691	WASP like actin nucleation promoting factor b. (501 aa)
	LOC109992252	CDC42 effector protein (Rho GTPase binding) 1a. (400 aa)
	ENSLBEP00000001462	CNX domain-containing protein. (142 aa)
	ENSLBEP00000001446	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (203 aa)
	LOC109982329	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1635 aa)
	LOC110003296	Uncharacterized protein. (138 aa)
	LOC109987944	Intersectin 1 (SH3 domain protein). (1614 aa)
	LOC109993896	Ankyrin repeat domain 33Bb. (482 aa)
	gfod2	Glucose-fructose oxidoreductase domain containing 2. (384 aa)
	LOC109990419	Rho GTPase activating protein 17. (886 aa)
	ENSLBEP00000033875	FH2 domain-containing protein. (210 aa)
	LOC109985891	Rho GTPase activating protein 17b. (523 aa)
	slc1a5	Solute carrier family 1 member 5. (536 aa)
	ENSLBEP00000013525	Uncharacterized protein. (443 aa)
	LOC109975744	CDC42 effector protein (Rho GTPase binding) 1b. (135 aa)
	pak1	Non-specific serine/threonine protein kinase. (576 aa)
	arhgap21	Rho GTPase activating protein 21a. (1869 aa)
	LOC109981556	Copine family member IX. (545 aa)
	ENSLBEP00000011895	HECT domain-containing protein. (101 aa)
	LOC109990637	Junction plakoglobin a. (705 aa)
	arhgap35	Uncharacterized protein. (1525 aa)
	FMN1	Formin 1. (1349 aa)
	LOC109987491	Glucose-fructose oxidoreductase domain containing 1. (395 aa)
	LOC110006006	DLC1 Rho GTPase activating protein. (1902 aa)
	cdc42ep4	CDC42 effector protein (Rho GTPase binding) 4b. (333 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (146 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	CPNE9	Copine family member 9. (511 aa)
	CPNE8	Copine 8. (564 aa)
	TRIP10	Thyroid hormone receptor interactor 10b. (503 aa)
	ENSLBEP00000010885	Uncharacterized protein. (533 aa)
	LOC109999324	Rho guanine nucleotide exchange factor (GEF) 7b. (651 aa)
	LOC109998041	E3 ubiquitin-protein ligase. (820 aa)
	LOC109980209	Uncharacterized protein. (577 aa)
	mpp3	Membrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3); Belongs to the MAGUK family. (611 aa)
	git2	G protein-coupled receptor kinase interacting ArfGAP 2a. (760 aa)
	LOC110002836	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (204 aa)
	mpp7	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family. (593 aa)
	ENSLBEP00000007679	CDC42 effector protein (Rho GTPase binding) 3. (288 aa)
	arhgap5	Rho GTPase activating protein 5. (1488 aa)
	LOC109977566	Protein kinase domain-containing protein. (154 aa)
	ENSLBEP00000007133	Uncharacterized protein. (69 aa)
	depdc1b	Rho-GAP domain-containing protein. (532 aa)
	ophn1	Oligophrenin 1. (794 aa)
	LOC109976813	FH2 domain-containing protein. (182 aa)
	LOC109984860	WASP like actin nucleation promoting factor a. (547 aa)
	ENSLBEP00000004810	CRIB domain-containing protein. (344 aa)
	LOC109995768	Uncharacterized protein. (748 aa)
	pak2	Non-specific serine/threonine protein kinase. (530 aa)
	LOC109981438	Rho GTPase activating protein 35b. (1529 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1509 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
	LOC109984271	Copine Vb. (580 aa)
	SYDE1	Synapse defective Rho GTPase homolog 1. (377 aa)
	CDC42	Cell division cycle 42. (203 aa)
	pak4	Non-specific serine/threonine protein kinase. (658 aa)
	LOC109993764	Ankyrin repeat domain 33. (457 aa)
	arhgap1	Uncharacterized protein. (430 aa)
	arhgef7	Rho guanine nucleotide exchange factor (GEF) 7a. (799 aa)
	LOC109993753	Uncharacterized protein. (207 aa)
	LOC109981137	G protein-coupled receptor kinase interacting ArfGAP 2b. (663 aa)
	iqgap1	IQ motif containing GTPase activating protein 1. (1630 aa)
	LOC109978465	Serine/threonine-protein kinase PAK 2. (530 aa)
	prex1	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1660 aa)
	LOC109988409	Formin 1. (907 aa)
	VANGL1	Vang-like protein. (536 aa)
	LOC109994783	Copine Va. (573 aa)
	LOC114920572	F-BAR domain-containing protein. (273 aa)
	arl13b	ADP-ribosylation factor-like 13b. (410 aa)
	ENSLBEP00000018976	Uncharacterized protein; Belongs to the protein kinase superfamily. (464 aa)
	LOC110000594	Ankyrin repeat domain 33ba. (526 aa)
	git1	G protein-coupled receptor kinase interacting ArfGAP 1. (787 aa)
	srgap2	SLIT-ROBO Rho GTPase activating protein 2. (1130 aa)
	LOC109984878	Ankyrin repeat domain 33Aa. (431 aa)
	LOC109995395	Uncharacterized protein. (191 aa)
	LOC109978257	Uncharacterized protein. (488 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC109994148	Cell division cycle 42. (191 aa)
	LOC109978256	PA domain-containing protein. (432 aa)
	ENSLBEP00000015189	Diaphanous-related formin 3. (360 aa)
	ENSLBEP00000015139	Uncharacterized protein. (113 aa)
	vamp3	V-SNARE coiled-coil homology domain-containing protein. (136 aa)
	LOC110001861	C2 domain-containing protein. (486 aa)
	LOC109985834	Rho GTPase activating protein 21b. (1737 aa)
	LOC110003864	Uncharacterized protein. (1457 aa)
	LOC109997785	Uncharacterized protein; Belongs to the MAGUK family. (526 aa)
	ENSLBEP00000025988	Rho-GAP domain-containing protein. (181 aa)
	ENSLBEP00000025989	Transferrin receptor 1a. (651 aa)
	LOC109987938	Uncharacterized protein; Belongs to the MAGUK family. (604 aa)
	LOC109987914	FH2 domain-containing protein. (351 aa)
	LOC109989243	Thyroid hormone receptor interactor 10a. (595 aa)
	ENSLBEP00000028313	CDC42 effector protein (Rho GTPase binding) 4a. (153 aa)
	LOC110003930	Transferrin receptor 1a. (770 aa)
	ENSLBEP00000029048	CDC42 binding protein kinase beta (DMPK-like). (657 aa)
	fnbp1	Formin binding protein 1b. (631 aa)
	ENSLBEP00000029576	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (343 aa)
	snap25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSLBEP00000001446	ENSLBEP00000014221	ENSLBEP00000001446	Cell division cycle 42.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.436
CDC42	ENSLBEP00000001462	ENSLBEP00000014221	ENSLBEP00000001462	Cell division cycle 42.	CNX domain-containing protein.	0.436
CDC42	ENSLBEP00000004810	ENSLBEP00000014221	ENSLBEP00000004810	Cell division cycle 42.	CRIB domain-containing protein.	0.916
CDC42	ENSLBEP00000007133	ENSLBEP00000014221	ENSLBEP00000007133	Cell division cycle 42.	Uncharacterized protein.	0.571
CDC42	ENSLBEP00000007679	ENSLBEP00000014221	ENSLBEP00000007679	Cell division cycle 42.	CDC42 effector protein (Rho GTPase binding) 3.	0.563
CDC42	ENSLBEP00000010885	ENSLBEP00000014221	ENSLBEP00000010885	Cell division cycle 42.	Uncharacterized protein.	0.916
CDC42	ENSLBEP00000011895	ENSLBEP00000014221	ENSLBEP00000011895	Cell division cycle 42.	HECT domain-containing protein.	0.477
CDC42	ENSLBEP00000013525	ENSLBEP00000014221	ENSLBEP00000013525	Cell division cycle 42.	Uncharacterized protein.	0.571
CDC42	ENSLBEP00000015139	ENSLBEP00000014221	ENSLBEP00000015139	Cell division cycle 42.	Uncharacterized protein.	0.933
CDC42	ENSLBEP00000015189	ENSLBEP00000014221	ENSLBEP00000015189	Cell division cycle 42.	Diaphanous-related formin 3.	0.933
CDC42	ENSLBEP00000018976	ENSLBEP00000014221	ENSLBEP00000018976	Cell division cycle 42.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.571
CDC42	ENSLBEP00000025988	ENSLBEP00000014221	ENSLBEP00000025988	Cell division cycle 42.	Rho-GAP domain-containing protein.	0.611
CDC42	ENSLBEP00000025989	ENSLBEP00000014221	ENSLBEP00000025989	Cell division cycle 42.	Transferrin receptor 1a.	0.412
CDC42	ENSLBEP00000028313	ENSLBEP00000014221	ENSLBEP00000028313	Cell division cycle 42.	CDC42 effector protein (Rho GTPase binding) 4a.	0.480
CDC42	ENSLBEP00000029048	ENSLBEP00000014221	ENSLBEP00000029048	Cell division cycle 42.	CDC42 binding protein kinase beta (DMPK-like).	0.571
CDC42	ENSLBEP00000029576	ENSLBEP00000014221	ENSLBEP00000029576	Cell division cycle 42.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.436
CDC42	ENSLBEP00000033875	ENSLBEP00000014221	ENSLBEP00000033875	Cell division cycle 42.	FH2 domain-containing protein.	0.548
CDC42	FMN1	ENSLBEP00000014221	ENSLBEP00000035492	Cell division cycle 42.	Formin 1.	0.548
CDC42	GJA1	ENSLBEP00000014221	ENSLBEP00000003337	Cell division cycle 42.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.436
CDC42	LOC109975744	ENSLBEP00000014221	ENSLBEP00000013451	Cell division cycle 42.	CDC42 effector protein (Rho GTPase binding) 1b.	0.769