(63 nodes) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 network (Labrus bergylta)

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second shell of interactors

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Predicted Interactions

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protein homology

Your Input:
	psmd2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC109977436	AAA domain-containing protein. (350 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
	psmb1	Proteasome subunit beta. (238 aa)
	psma1	Proteasome subunit alpha type. (271 aa)
	LOC109994064	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	LOC109983646	Proteasome subunit alpha type. (246 aa)
	psmc1	Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
	LOC109990045	Proteasome 26S subunit, non-ATPase 4b. (375 aa)
	psmf1	Proteasome inhibitor subunit 1. (274 aa)
	psma2	Proteasome subunit alpha type. (234 aa)
	PSME2	Proteasome activator subunit 2. (245 aa)
	LOC110006134	Proteasome 26S subunit, non-ATPase 6. (386 aa)
	LOC109976956	Proteasome 26S subunit, non-ATPase 3. (516 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (801 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (330 aa)
	psmb2	Proteasome subunit beta. (199 aa)
	psme3	Proteasome activator subunit 3. (267 aa)
	LOC109991907	Proteasome subunit alpha type. (246 aa)
	LOC109989024	Glycogen synthase kinase 3 alpha b. (506 aa)
	psma5	Proteasome subunit alpha type. (241 aa)
	ENSLBEP00000015835	Protein kinase domain-containing protein. (182 aa)
	LOC109992389	Proteasome 26S subunit, non-ATPase 11b. (422 aa)
	LOC110001694	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	psmd12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	ENSLBEP00000018568	RPN6_N domain-containing protein. (95 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	LOC109975122	Proteasome subunit beta. (275 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (782 aa)
	ubb	Ubiquitin B. (759 aa)
	psmb3	Proteasome subunit beta. (206 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (644 aa)
	LOC109986839	Proteasome subunit alpha type. (261 aa)
	psme2	Proteasome activator subunit 2. (340 aa)
	psmd8	Proteasome 26S subunit, non-ATPase 8. (265 aa)
	psma3	Proteasome subunit alpha type. (255 aa)
	LOC110003860	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (425 aa)
	LOC110005673	Proteasome subunit alpha type. (261 aa)
	PSMD11	PCI domain-containing protein. (473 aa)
	psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	psma6	Proteasome subunit alpha type. (246 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	LOC109997195	Nuclear factor, erythroid 2-like 1a. (869 aa)
	LOC109998372	Proteasome subunit beta. (271 aa)
	psmd5	Proteasome 26S subunit, non-ATPase 5. (504 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (258 aa)
	psmb7	Proteasome subunit beta. (286 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (404 aa)
	LOC110002717	Proteasome subunit beta 12. (217 aa)
	LOC110002716	Proteasome subunit beta. (275 aa)
	psmd1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (913 aa)
	psmd6	Proteasome 26S subunit, non-ATPase 6. (386 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	LOC109989338	26S proteasome non-ATPase regulatory subunit 3-like. (516 aa)
	LOC109995013	Proteasome 26S subunit, non-ATPase 4a. (372 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	psme1	Proteasome activator subunit 1. (252 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	rbx1	Zf-rbx1 domain-containing protein. (218 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (351 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000015835	ENSLBEP00000018568	ENSLBEP00000015835	ENSLBEP00000018568	Protein kinase domain-containing protein.	RPN6_N domain-containing protein.	0.565
ENSLBEP00000015835	LOC109975122	ENSLBEP00000015835	ENSLBEP00000019647	Protein kinase domain-containing protein.	Proteasome subunit beta.	0.554
ENSLBEP00000015835	LOC109976956	ENSLBEP00000015835	ENSLBEP00000012821	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 3.	0.519
ENSLBEP00000015835	LOC109977436	ENSLBEP00000015835	ENSLBEP00000002042	Protein kinase domain-containing protein.	AAA domain-containing protein.	0.565
ENSLBEP00000015835	LOC109983646	ENSLBEP00000015835	ENSLBEP00000006976	Protein kinase domain-containing protein.	Proteasome subunit alpha type.	0.524
ENSLBEP00000015835	LOC109986839	ENSLBEP00000015835	ENSLBEP00000022491	Protein kinase domain-containing protein.	Proteasome subunit alpha type.	0.562
ENSLBEP00000015835	LOC109989338	ENSLBEP00000015835	ENSLBEP00000034554	Protein kinase domain-containing protein.	26S proteasome non-ATPase regulatory subunit 3-like.	0.519
ENSLBEP00000015835	LOC109990045	ENSLBEP00000015835	ENSLBEP00000007481	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 4b.	0.603
ENSLBEP00000015835	LOC109991907	ENSLBEP00000015835	ENSLBEP00000014761	Protein kinase domain-containing protein.	Proteasome subunit alpha type.	0.524
ENSLBEP00000015835	LOC109992389	ENSLBEP00000015835	ENSLBEP00000015955	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 11b.	0.565
ENSLBEP00000015835	LOC109995013	ENSLBEP00000015835	ENSLBEP00000034557	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 4a.	0.603
ENSLBEP00000015835	LOC109997195	ENSLBEP00000015835	ENSLBEP00000029218	Protein kinase domain-containing protein.	Nuclear factor, erythroid 2-like 1a.	0.756
ENSLBEP00000015835	LOC109998372	ENSLBEP00000015835	ENSLBEP00000029365	Protein kinase domain-containing protein.	Proteasome subunit beta.	0.554
ENSLBEP00000015835	LOC110001694	ENSLBEP00000015835	ENSLBEP00000015961	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 13.	0.521
ENSLBEP00000015835	LOC110002716	ENSLBEP00000015835	ENSLBEP00000032310	Protein kinase domain-containing protein.	Proteasome subunit beta.	0.554
ENSLBEP00000015835	LOC110002717	ENSLBEP00000015835	ENSLBEP00000032218	Protein kinase domain-containing protein.	Proteasome subunit beta 12.	0.596
ENSLBEP00000015835	LOC110005673	ENSLBEP00000015835	ENSLBEP00000025978	Protein kinase domain-containing protein.	Proteasome subunit alpha type.	0.562
ENSLBEP00000015835	LOC110006134	ENSLBEP00000015835	ENSLBEP00000012107	Protein kinase domain-containing protein.	Proteasome 26S subunit, non-ATPase 6.	0.555
ENSLBEP00000015835	NFE2L1	ENSLBEP00000015835	ENSLBEP00000013129	Protein kinase domain-containing protein.	Nuclear factor, erythroid 2 like 1.	0.756
ENSLBEP00000015835	PSMD11	ENSLBEP00000015835	ENSLBEP00000026166	Protein kinase domain-containing protein.	PCI domain-containing protein.	0.565