(15 nodes) Synthesis and degradation of ketone bodies network (Labrus bergylta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	oxct1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (527 aa)
	LOC109995230	Uncharacterized protein. (104 aa)
	ENSLBEP00000006227	Uncharacterized protein. (72 aa)
	LOC109984190	Zgc:113142; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
	LOC110006114	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (357 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	hmgcl	3-hydroxy-3-methylglutaryl-CoA lyase. (334 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	LOC109989630	Uncharacterized protein. (123 aa)
	LOC109983872	Zgc:113054. (526 aa)
	LOC110001204	3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (267 aa)
	LOC109996161	Uncharacterized protein. (107 aa)
	hmgcll1	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (336 aa)
	ENSLBEP00000037482	annotation not available (357 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000006227	ENSLBEP00000037482	ENSLBEP00000006227	ENSLBEP00000037482	Uncharacterized protein.	annotation not available	0.980
ENSLBEP00000006227	LOC109983872	ENSLBEP00000006227	ENSLBEP00000025766	Uncharacterized protein.	Zgc:113054.	0.529
ENSLBEP00000006227	LOC110006114	ENSLBEP00000006227	ENSLBEP00000011276	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.980
ENSLBEP00000006227	bdh2	ENSLBEP00000006227	ENSLBEP00000028030	Uncharacterized protein.	3-hydroxybutyrate dehydrogenase, type 2.	0.529
ENSLBEP00000006227	hmgcl	ENSLBEP00000006227	ENSLBEP00000017552	Uncharacterized protein.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.813
ENSLBEP00000006227	hmgcll1	ENSLBEP00000006227	ENSLBEP00000033341	Uncharacterized protein.	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.813
ENSLBEP00000006227	oxct1	ENSLBEP00000006227	ENSLBEP00000004501	Uncharacterized protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.904
ENSLBEP00000037482	ENSLBEP00000006227	ENSLBEP00000037482	ENSLBEP00000006227	annotation not available	Uncharacterized protein.	0.980
ENSLBEP00000037482	LOC109983872	ENSLBEP00000037482	ENSLBEP00000025766	annotation not available	Zgc:113054.	0.482
ENSLBEP00000037482	LOC109989630	ENSLBEP00000037482	ENSLBEP00000022072	annotation not available	Uncharacterized protein.	0.982
ENSLBEP00000037482	LOC109995230	ENSLBEP00000037482	ENSLBEP00000005277	annotation not available	Uncharacterized protein.	0.979
ENSLBEP00000037482	LOC109996161	ENSLBEP00000037482	ENSLBEP00000029200	annotation not available	Uncharacterized protein.	0.979
ENSLBEP00000037482	acat1	ENSLBEP00000037482	ENSLBEP00000016020	annotation not available	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.988
ENSLBEP00000037482	acat2	ENSLBEP00000037482	ENSLBEP00000017833	annotation not available	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.988
ENSLBEP00000037482	bdh2	ENSLBEP00000037482	ENSLBEP00000028030	annotation not available	3-hydroxybutyrate dehydrogenase, type 2.	0.482
ENSLBEP00000037482	hmgcl	ENSLBEP00000037482	ENSLBEP00000017552	annotation not available	3-hydroxy-3-methylglutaryl-CoA lyase.	0.892
ENSLBEP00000037482	hmgcll1	ENSLBEP00000037482	ENSLBEP00000033341	annotation not available	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.892
ENSLBEP00000037482	oxct1	ENSLBEP00000037482	ENSLBEP00000004501	annotation not available	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.916
LOC109983872	ENSLBEP00000006227	ENSLBEP00000025766	ENSLBEP00000006227	Zgc:113054.	Uncharacterized protein.	0.529
LOC109983872	ENSLBEP00000037482	ENSLBEP00000025766	ENSLBEP00000037482	Zgc:113054.	annotation not available	0.482