(48 nodes) Terpenoid backbone biosynthesis network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	zc3hc1	Zinc finger, C3HC-type containing 1. (504 aa)
	pcyox1l	Prenylcysteine oxidase 1 like. (504 aa)
	ENSLBEP00000001343	Ras converting CAAX endopeptidase 1b. (190 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (903 aa)
	ctdp1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (986 aa)
	LOC109989429	3-hydroxy-3-methylglutaryl coenzyme A reductase. (885 aa)
	LOC109995230	Uncharacterized protein. (104 aa)
	ENSLBEP00000006227	Uncharacterized protein. (72 aa)
	LOC109977789	F-box protein 30a. (735 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	rce1	Ras converting CAAX endopeptidase 1a. (312 aa)
	mvd	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (402 aa)
	dhdds	Alkyl transferase; Belongs to the UPP synthase family. (335 aa)
	LOC110006114	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (357 aa)
	slc35f2	Solute carrier family 35 member F2. (389 aa)
	LOC109991235	Info solute carrier family 35 member F2, like. (412 aa)
	oma1	OMA1 zinc metallopeptidase. (510 aa)
	pdss1	Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family. (422 aa)
	LOC109980473	Uncharacterized protein. (153 aa)
	LOC110004950	Phosphomevalonate kinase. (196 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	LOC109979768	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (457 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (509 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	fnta	Farnesyltransferase, CAAX box, alpha. (375 aa)
	LOC109975918	Uncharacterized protein. (210 aa)
	icmt	Protein-S-isoprenylcysteine O-methyltransferase. (291 aa)
	RUSC2	RUN and SH3 domain containing 2. (919 aa)
	LOC109989630	Uncharacterized protein. (123 aa)
	ENSLBEP00000022123	RUN and SH3 domain containing 2. (629 aa)
	LOC109983288	F-box protein 30b. (735 aa)
	LOC110003117	Phosphomevalonate kinase. (194 aa)
	churc1	Churchill domain containing 1. (112 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (384 aa)
	slc35f1	Solute carrier family 35 member F1. (467 aa)
	nus1	NUS1 dehydrodolichyl diphosphate synthase subunit. (292 aa)
	LOC109996161	Uncharacterized protein. (107 aa)
	pcyox1	Prenylcysteine oxidase 1. (512 aa)
	LOC109991548	Si:dkey-193c22.1. (366 aa)
	ENSLBEP00000030919	RUN domain-containing protein. (107 aa)
	tomm70	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). (577 aa)
	rusc1	RUN and SH3 domain containing 1. (1216 aa)
	fdps	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (358 aa)
	ENSLBEP00000037482	annotation not available (357 aa)
	ENSLBEP00000037562	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	idi1	Isopentenyl-diphosphate delta isomerase 1. (288 aa)
	FBXO40	F-box protein 40. (666 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000001343	LOC109979768	ENSLBEP00000001343	ENSLBEP00000017563	Ras converting CAAX endopeptidase 1b.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.913
ENSLBEP00000001343	LOC109991548	ENSLBEP00000001343	ENSLBEP00000030917	Ras converting CAAX endopeptidase 1b.	Si:dkey-193c22.1.	0.832
ENSLBEP00000001343	churc1	ENSLBEP00000001343	ENSLBEP00000027537	Ras converting CAAX endopeptidase 1b.	Churchill domain containing 1.	0.904
ENSLBEP00000001343	dhdds	ENSLBEP00000001343	ENSLBEP00000010065	Ras converting CAAX endopeptidase 1b.	Alkyl transferase; Belongs to the UPP synthase family.	0.418
ENSLBEP00000001343	fnta	ENSLBEP00000001343	ENSLBEP00000018156	Ras converting CAAX endopeptidase 1b.	Farnesyltransferase, CAAX box, alpha.	0.915
ENSLBEP00000001343	icmt	ENSLBEP00000001343	ENSLBEP00000019875	Ras converting CAAX endopeptidase 1b.	Protein-S-isoprenylcysteine O-methyltransferase.	0.929
ENSLBEP00000001343	oma1	ENSLBEP00000001343	ENSLBEP00000012403	Ras converting CAAX endopeptidase 1b.	OMA1 zinc metallopeptidase.	0.952
ENSLBEP00000001343	zmpste24	ENSLBEP00000001343	ENSLBEP00000007334	Ras converting CAAX endopeptidase 1b.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.977
ENSLBEP00000006227	ENSLBEP00000037482	ENSLBEP00000006227	ENSLBEP00000037482	Uncharacterized protein.	annotation not available	0.980
ENSLBEP00000006227	ENSLBEP00000037562	ENSLBEP00000006227	ENSLBEP00000037562	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.416
ENSLBEP00000006227	LOC109989429	ENSLBEP00000006227	ENSLBEP00000004610	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.416
ENSLBEP00000006227	LOC110006114	ENSLBEP00000006227	ENSLBEP00000011276	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.980
ENSLBEP00000006227	idi1	ENSLBEP00000006227	ENSLBEP00000037669	Uncharacterized protein.	Isopentenyl-diphosphate delta isomerase 1.	0.462
ENSLBEP00000006227	mvd	ENSLBEP00000006227	ENSLBEP00000009914	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.688
ENSLBEP00000006227	mvk	ENSLBEP00000006227	ENSLBEP00000014972	Uncharacterized protein.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.844
ENSLBEP00000022123	ENSLBEP00000037482	ENSLBEP00000022123	ENSLBEP00000037482	RUN and SH3 domain containing 2.	annotation not available	0.578
ENSLBEP00000022123	ENSLBEP00000037562	ENSLBEP00000022123	ENSLBEP00000037562	RUN and SH3 domain containing 2.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.494
ENSLBEP00000022123	LOC109979768	ENSLBEP00000022123	ENSLBEP00000017563	RUN and SH3 domain containing 2.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.661
ENSLBEP00000022123	LOC109989429	ENSLBEP00000022123	ENSLBEP00000004610	RUN and SH3 domain containing 2.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.494
ENSLBEP00000022123	LOC109991235	ENSLBEP00000022123	ENSLBEP00000011582	RUN and SH3 domain containing 2.	Info solute carrier family 35 member F2, like.	0.491