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| | accD | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (300 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa) |
| | gabD-1 | Succinate-semialdehyde dehydrogenase (NADP(+)) 1; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (493 aa) |
| | gabT | 4-aminobutyrate aminotransferase; Protein involved in catalytic activity, pyridoxal phosphate binding and gamma-aminobutyric acid metabolic process; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | purU-1 | Formyltetrahydrofolate deformylase 1; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | fadB | enoyl-CoA hydratase; Protein involved in catalytic activity and metabolic process; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | tme | NADP-dependent malic enzyme; Protein involved in nucleotide binding, NAD binding and oxidation-reduction process. (760 aa) |
| | APO66296.1 | acyl-CoA dehydrogenase protein; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, metabolic process and oxidation-reduction process. (598 aa) |
| | fadA | acetyl-CoA C-acetyltransferase; Protein involved in transferase activity, transferring acyl groups other than amino-acyl groups and metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa) |
| | fadJ | Fatty acid oxidation complex subunit alpha FadJ; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process. (738 aa) |
| | APO66305.1 | 3-hydroxyisobutyryl-CoA hydrolase; Protein involved in catalytic activity and metabolic process. (353 aa) |
| | ttuC-1 | Trifunctional D-malate dehydrogenase/tartrate dehydrogenase/tartrate decarboxylase 1; Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, NAD binding and oxidation-reduction process. (357 aa) |
| | APO66341.1 | Tartrate dehydrogenase/decarboxylase protein; Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, NAD binding and oxidation-reduction process. (347 aa) |
| | gabD-2 | Succinate-semialdehyde dehydrogenase (NADP(+)) 2; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (497 aa) |
| | APO66354.1 | Succinate-semialdehyde dehydrogenase (NADP(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (485 aa) |
| | APO66362.1 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (484 aa) |
| | acsA-1 | acetyl-CoA synthetase 1; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa) |
| | APO66473.1 | acetoacetyl-CoA synthetase protein; Protein involved in acetoacetate-CoA ligase activity and lipid metabolic process. (650 aa) |
| | iolA | Methylmalonate-semialdehyde dehydrogenase (acylating); Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (498 aa) |
| | APO66654.1 | acyl-CoA dehydrogenase protein; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, metabolic process and oxidation-reduction process. (592 aa) |
| | APO66655.1 | crotonase/enoyl-CoA hydratase family protein; Protein involved in catalytic activity and metabolic process. (250 aa) |
| | APO66705.1 | Formate dehydrogenase protein; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (399 aa) |
| | ppdK | Pyruvate phosphate dikinase; Protein involved in catalytic activity, ligase activity and phosphorylation; Belongs to the PEP-utilizing enzyme family. (890 aa) |
| | APO66826.1 | Protein involved in catalytic activity and metabolic process. (297 aa) |
| | etf-1 | Electron transfer flavoprotein-ubiquinone oxidoreductase 1; Accepts electrons from ETF and reduces ubiquinone. (554 aa) |
| | APO67018.1 | 2-isopropylmalate/homocitrate synthase family transferase protein; Protein involved in catalytic activity and leucine biosynthetic process; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa) |
| | APO67134.1 | Phenylacetic acid degradation-related protein. (141 aa) |
| | APO67135.1 | crotonase/enoyl-CoA hydratase family protein; Protein involved in catalytic activity and metabolic process; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa) |
| | birA | biotin--(acetyl-CoA carboxylase) ligase; Protein involved in biotin-[acetyl-CoA-carboxylase] ligase activity and protein modification process. (254 aa) |
| | APO67171.1 | Protein involved in hydrolase activity. (556 aa) |
| | APO67172.1 | methylmalonyl-CoA epimerase protein. (134 aa) |
| | APO67200.1 | acyl-CoA dehydrogenase protein; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, metabolic process and oxidation-reduction process. (549 aa) |
| | accC-1 | acetyl-CoA carboxylase biotin carboxylase subunit AccC 1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | accB-1 | acetyl-CoA carboxylase biotin carboxyl carrier subunit AccB 1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Protein involved in catalytic activity and metabolic process; Belongs to the IlvD/Edd family. (612 aa) |
| | gltA | Citrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer and cellular carbohydrate metabolic process; Belongs to the citrate synthase family. (429 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (458 aa) |
| | pdhC | Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (461 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. (482 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (323 aa) |
| | APO67701.1 | Citrate synthase protein; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer and cellular carbohydrate metabolic process. (381 aa) |
| | citA | Citrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer and cellular carbohydrate metabolic process; Belongs to the citrate synthase family. (361 aa) |
| | lipB | Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (237 aa) |
| | pccA-1 | propionyl-CoA carboxylase subunit alpha 1; Protein involved in ATP binding, ligase activity and metabolic process. (669 aa) |
| | pccB-1 | propionyl-CoA carboxylase beta subunit 1; Protein involved in ligase activity. (510 aa) |
| | icd | Isocitrate dehydrogenase (NADP(+)); Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and oxidation-reduction process; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | dme | Malic enzyme; Protein involved in nucleotide binding, NAD binding and oxidation-reduction process. (770 aa) |
| | fumC | Fumarate hydratase class 2; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | fumA | Fumarate hydratase class 1; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (535 aa) |
| | APO67906.1 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process. (289 aa) |
| | APO68054.1 | crotonase/enoyl-CoA hydratase family protein; Protein involved in catalytic activity and metabolic process. (329 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvH | Acetolactate synthase 3 small subunit; Protein involved in acetolactate synthase activity and branched chain family amino acid biosynthetic process. (190 aa) |
| | ilvI | Acetolactate synthase 3 large subunit; Protein involved in magnesium ion binding, acetolactate synthase activity, thiamine pyrophosphate binding, flavin adenine dinucleotide binding and branched chain family amino acid biosynthetic process. (585 aa) |
| | APO68184.1 | D-lactate dehydrogenase (cytochrome) protein; Protein involved in catalytic activity, oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. (470 aa) |
| | APO68254.1 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. (552 aa) |
| | APO68296.1 | crotonase/enoyl-CoA hydratase family protein; Protein involved in catalytic activity and metabolic process. (257 aa) |
| | APO68297.1 | Coenzyme A transferase protein; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (537 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (297 aa) |
| | APO68381.1 | MaoC-like dehydratase protein; Overlaps another CDS with the same product name; Protein involved in oxidoreductase activity and metabolic process. (153 aa) |
| | APO68382.1 | MaoC-like dehydratase protein; Overlaps another CDS with the same product name; Protein involved in oxidoreductase activity and metabolic process. (155 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (571 aa) |
| | APO68439.1 | Omega amino acid--pyruvate aminotransferase protein; Protein involved in catalytic activity and pyridoxal phosphate binding; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa) |
| | lldD-1 | L-lactate dehydrogenase (cytochrome) 1; Protein involved in catalytic activity, oxidoreductase activity and oxidation-reduction process. (380 aa) |
| | IlvD-3 | Dihydroxy-acid/6-phosphogluconate dehydratase protein; Protein involved in catalytic activity and metabolic process; Belongs to the IlvD/Edd family. (594 aa) |
| | APO68767.1 | Sulfur acquisition oxidoreductase SfnB family protein; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, metabolic process and oxidation-reduction process. (358 aa) |
| | APO69396.1 | AMP-dependent synthetase/ligase protein; Protein involved in catalytic activity and metabolic process. (546 aa) |
| | etfB-1 | Electron transport flavoprotein subunit beta 1; Protein involved in electron carrier activity. (249 aa) |
| | etfA-1 | Electron-transport flavoprotein subunit alpha 1; Protein involved in electron carrier activity and flavin adenine dinucleotide binding. (309 aa) |
| | hbdA | 3-hydroxybutyryl-CoA dehydrogenase; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process. (293 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | APO69506.1 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. (468 aa) |
| | sucB | Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component; Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle and oxidation-reduction process. (994 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit; Protein involved in electron carrier activity, iron-sulfur cluster binding and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (613 aa) |
| | sdhD | Protein involved in succinate dehydrogenase activity, heme binding and tricarboxylic acid cycle. (126 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 subunit; Protein involved in succinate dehydrogenase activity and tricarboxylic acid cycle. (131 aa) |
| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | tesB | acyl-CoA thioesterase 2; Protein involved in acyl-CoA hydrolase activity and acyl-CoA metabolic process. (294 aa) |
| | APO69607.1 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process. (512 aa) |
| | APO69618.1 | acyl-CoA dehydrogenase protein; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, metabolic process and oxidation-reduction process. (393 aa) |
| | phbB | acetoacetyl-CoA reductase; Protein involved in nucleotide binding, poly-hydroxybutyrate biosynthetic process and oxidation-reduction process. (241 aa) |
| | phbA | acetyl-CoA acetyltransferase; Protein involved in transferase activity, transferring acyl groups other than amino-acyl groups and metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1154 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | acsA-2 | acetyl-CoA synthetase 2; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa) |
| | APO69739.1 | propionyl-CoA ligase protein; Protein involved in catalytic activity and metabolic process. (636 aa) |
