| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score | 
| APO66362.1 | APO67906.1 | IE4872_CH00704 | IE4872_CH02291 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | 0.913 | 
| APO66362.1 | APO68297.1 | IE4872_CH00704 | IE4872_CH02690 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | Coenzyme A transferase protein; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family.  | 0.900 | 
| APO66362.1 | APO68439.1 | IE4872_CH00704 | IE4872_CH02834 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | Omega amino acid--pyruvate aminotransferase protein; Protein involved in catalytic activity and pyridoxal phosphate binding; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  | 0.903 | 
| APO66362.1 | APO69396.1 | IE4872_CH00704 | IE4872_CH03811 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | AMP-dependent synthetase/ligase protein; Protein involved in catalytic activity and metabolic process.  | 0.926 | 
| APO66362.1 | APO69607.1 | IE4872_CH00704 | IE4872_CH04026 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.915 | 
| APO66362.1 | APO69739.1 | IE4872_CH00704 | IE4872_CH04159 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | propionyl-CoA ligase protein; Protein involved in catalytic activity and metabolic process.  | 0.853 | 
| APO66362.1 | acsA-1 | IE4872_CH00704 | IE4872_CH00705 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | acetyl-CoA synthetase 1; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.  | 0.956 | 
| APO66362.1 | acsA-2 | IE4872_CH00704 | IE4872_CH04156 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | acetyl-CoA synthetase 2; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.  | 0.926 | 
| APO66362.1 | iolA | IE4872_CH00704 | IE4872_CH00826 | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | Methylmalonate-semialdehyde dehydrogenase (acylating); Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.923 | 
| APO67906.1 | APO66362.1 | IE4872_CH02291 | IE4872_CH00704 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.913 | 
| APO67906.1 | APO68297.1 | IE4872_CH02291 | IE4872_CH02690 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | Coenzyme A transferase protein; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family.  | 0.800 | 
| APO67906.1 | APO68439.1 | IE4872_CH02291 | IE4872_CH02834 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | Omega amino acid--pyruvate aminotransferase protein; Protein involved in catalytic activity and pyridoxal phosphate binding; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  | 0.900 | 
| APO67906.1 | APO69396.1 | IE4872_CH02291 | IE4872_CH03811 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | AMP-dependent synthetase/ligase protein; Protein involved in catalytic activity and metabolic process.  | 0.807 | 
| APO67906.1 | APO69607.1 | IE4872_CH02291 | IE4872_CH04026 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.913 | 
| APO67906.1 | APO69739.1 | IE4872_CH02291 | IE4872_CH04159 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | propionyl-CoA ligase protein; Protein involved in catalytic activity and metabolic process.  | 0.807 | 
| APO67906.1 | acsA-1 | IE4872_CH02291 | IE4872_CH00705 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | acetyl-CoA synthetase 1; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.  | 0.807 | 
| APO67906.1 | acsA-2 | IE4872_CH02291 | IE4872_CH04156 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | acetyl-CoA synthetase 2; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.  | 0.807 | 
| APO67906.1 | iolA | IE4872_CH02291 | IE4872_CH00826 | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | Methylmalonate-semialdehyde dehydrogenase (acylating); Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.931 | 
| APO68297.1 | APO66362.1 | IE4872_CH02690 | IE4872_CH00704 | Coenzyme A transferase protein; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family.  | Aldehyde dehydrogenase (NAD(+)) protein; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, metabolic process and oxidation-reduction process.  | 0.900 | 
| APO68297.1 | APO67906.1 | IE4872_CH02690 | IE4872_CH02291 | Coenzyme A transferase protein; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family.  | 3-hydroxyisobutyrate dehydrogenase-related protein; Protein involved in nucleotide binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, coenzyme binding and oxidation-reduction process.  | 0.800 |