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SYN_00095 SYN_00095 SYN_00107 SYN_00107 purA purA SYN_00176 SYN_00176 ahcY ahcY SYN_00417 SYN_00417 SYN_00426 SYN_00426 SYN_00446 SYN_00446 SYN_00461 SYN_00461 purL purL SYN_00522 SYN_00522 SYN_00606 SYN_00606 SYN_00607 SYN_00607 SYN_00733 SYN_00733 SYN_00800 SYN_00800 purN purN purM purM guaB guaB SYN_00901 SYN_00901 SYN_00907 SYN_00907 SYN_01147 SYN_01147 SYN_01253 SYN_01253 SYN_01255 SYN_01255 SYN_01257 SYN_01257 pyrF pyrF pyrB pyrB pyrC pyrC SYN_01613 SYN_01613 purF purF carB carB guaA guaA carA carA SYN_01628 SYN_01628 SYN_01629 SYN_01629 SYN_01630 SYN_01630 SYN_01631 SYN_01631 SYN_01778 SYN_01778 SYN_01896 SYN_01896 SYN_01966 SYN_01966 surE surE fhs fhs SYN_02264 SYN_02264 glyA glyA purD purD purH purH purE purE SYN_02450 SYN_02450 carB-2 carB-2 pyrE pyrE SYN_02703 SYN_02703 purC purC pyrK pyrK pyrD pyrD SYN_02872 SYN_02872 folD folD pyrR pyrR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SYN_00095Hypothetical cytosolic protein. (242 aa)
SYN_00107Phosphoribosylaminoimidazole-succinocarboxamide synthase. (238 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (439 aa)
SYN_00176Methylenetetrahydrofolate reductase. (618 aa)
ahcYS-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (519 aa)
SYN_00417S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (392 aa)
SYN_00426Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
SYN_00446Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (295 aa)
SYN_00461Glutamate formiminotransferase. (345 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (993 aa)
SYN_00522Phosphoribosylformylglycinamidine synthase; Glutamine amidotransferase domain. (290 aa)
SYN_00606Glutamate synthase (NADPH). (471 aa)
SYN_00607Flavodoxin oxidoreductase. (278 aa)
SYN_00733Xanthine permease. (436 aa)
SYN_00800Ferridoxin. (137 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (223 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (347 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
SYN_00901Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (174 aa)
SYN_00907Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (465 aa)
SYN_01147Arginase; Belongs to the arginase family. (357 aa)
SYN_01253Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (325 aa)
SYN_01255o-acetyl-L-homoserine sulfhydrolase / O-acetyl-L-serine sulfhydrolase; Bifunctional. (435 aa)
SYN_01257Serine acetyltransferase. (318 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (251 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (426 aa)
SYN_01613Glutamine synthetase. (698 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (470 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1069 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (510 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (401 aa)
SYN_01628Glutamine synthetase. (452 aa)
SYN_01629Glutamate synthase (NADPH). (777 aa)
SYN_01630Glutamate synthase (NADPH); Belongs to the glutamate synthase family. (544 aa)
SYN_01631Glutamate synthase (NADPH). (376 aa)
SYN_01778Hypothetical cytosolic protein. (395 aa)
SYN_01896Glutamine amidotransferases class-II. (315 aa)
SYN_01966Aminotransferase. (398 aa)
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (266 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (565 aa)
SYN_02264UDP-sugar diphosphatase / 5'-nucleotidase; Bifunctional; Belongs to the 5'-nucleotidase family. (553 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (462 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional. (528 aa)
purEPhosphoribosylaminoimidazole carboxylase carboxyltransferase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa)
SYN_02450Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (173 aa)
carB-2Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1066 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa)
SYN_027035-methyltetrahydrofolate--homocysteine methyltransferase. (813 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (294 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (275 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (330 aa)
SYN_02872Methylenetetrahydrofolate reductase. (524 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (324 aa)
pyrRUracil phosphoribosyltransferase / pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (181 aa)
Your Current Organism:
Syntrophus aciditrophicus
NCBI taxonomy Id: 56780
Other names: S. aciditrophicus SB, Syntrophus aciditrophicus SB, Syntrophus aciditrophicus str. SB, Syntrophus aciditrophicus strain SB
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