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| | dnaX | DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (588 aa) |
| | trpF-2 | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (230 aa) |
| | SYN_02496 | Cytidylate kinase. (218 aa) |
| | SYN_02528 | Radical SAM superfamily. (408 aa) |
| | adk-2 | Adenylate kinase / nucleoside-diphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (241 aa) |
| | SYN_02555 | Radical SAM superfamily protein. (331 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (456 aa) |
| | SYN_02568 | 8-amino-7-oxononanoate synthase. (387 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa) |
| | SYN_02574 | Hydrolase, isochorismatase family. (179 aa) |
| | SYN_02578 | Dihydropteroate synthase related enzyme; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (308 aa) |
| | carB-2 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1066 aa) |
| | trpD-2 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (448 aa) |
| | SYN_02591 | Indole-3-glycerol phosphate synthase. (245 aa) |
| | trpF-3 | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (249 aa) |
| | SYN_02635 | acetyl-CoA synthetase. (656 aa) |
| | SYN_02650 | CDP-4-dehydro-6-deoxy-D-glucose 3-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (201 aa) |
| | SYN_02652 | CDP-4-dehydro-6-deoxy-D-gulose 4-reductase. (314 aa) |
| | SYN_02661 | NAD dependent epimerase/dehydratase family. (318 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (294 aa) |
| | SYN_02758 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa) |
| | dacA | Hypothetical membrane protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (499 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa) |
| | SYN_02778 | Dihydropteroate synthase. (415 aa) |
| | SYN_02827 | RNA polymerase flagellar sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (261 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (275 aa) |
| | pyrD | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (330 aa) |
| | SYN_02853 | Adenylate cyclase. (653 aa) |
| | nadK | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (324 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (235 aa) |
| | coaX | Bvg accessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (254 aa) |
| | SYN_02885 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Belongs to the NadC/ModD family. (283 aa) |
| | SYN_02896 | 4-hydroxybenzoate--CoA ligase / benzoate--CoA ligase; Bifunctional. (524 aa) |
| | SYN_02898 | 4-hydroxybenzoate--CoA ligase / benzoate--CoA ligase; Bifunctional. (524 aa) |
| | SYN_02901 | Iron-sulfur cluster-binding protein. (285 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (174 aa) |
| | SYN_02931 | Hypothetical cytosolic protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (175 aa) |
| | SYN_02960 | UDP-N-acetylglucosamine pyrophosphorylase. (452 aa) |
| | atpE-2 | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (126 aa) |
| | queH | Hypothetical cytosolic protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (202 aa) |
| | SYN_02976 | Reverse transcriptase. (312 aa) |
| | SYN_02985 | DNA polymerase III, gamma subunit. (329 aa) |
| | SYN_03000 | Pyridoxamine phosphate oxidase. (204 aa) |
| | cmk | Cytidylate kinase. (256 aa) |
| | SYN_03199 | Hypothetical cytosolic protein. (94 aa) |
| | SYN_03353 | Xanthine-guanine phosphoribosyltransferase. (204 aa) |
| | SYN_03479 | Hypothetical cytosolic protein. (52 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa) |
| | SYN_02479 | Exonuclease. (88 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (650 aa) |
| | SYN_02450 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (173 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional. (528 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (462 aa) |
| | SYN_02437 | UDP-N-acetylglucosamine pyrophosphorylase. (258 aa) |
| | SYN_02417 | 2-aminobenzoate-CoA ligase. (531 aa) |
| | nusB | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (161 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribBA | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (414 aa) |
| | SYN_02370 | Riboflavin synthase alpha chain. (215 aa) |
| | SYN_02276 | Precorrin-2 dehydrogenase / Sirohydrochlorin ferrochelatase; Bifunctional. (216 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (472 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (306 aa) |
| | SYN_02272 | uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase; Bifunctional. (516 aa) |
| | SYN_02268 | Radical SAM superfamily protein. (397 aa) |
| | SYN_02267 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (324 aa) |
| | SYN_02266 | Radical SAM superfamily protein. (369 aa) |
| | SYN_02265 | Transcriptional regulator AsnC family. (157 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (901 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | adk | Adenylate kinase / nucleoside-diphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (235 aa) |
| | SYN_02186 | Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (404 aa) |
| | SYN_02177 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (423 aa) |
| | SYN_02163 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). (176 aa) |
| | SYN_02148 | Molybdopterin biosynthesis MoeA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (403 aa) |
| | SYN_02134 | Biotin synthase. (351 aa) |
| | SYN_02133 | thiH protein. (464 aa) |
| | SYN_02105 | F0F1-type ATP synthase, gamma subunit. (216 aa) |
| | atpA2 | F0F1-type ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (519 aa) |
| | atpF2 | F0F1-type ATP synthase, subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (274 aa) |
| | atpE | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type proton-ATPase, subunit K; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (92 aa) |
| | atpB-2 | F0F1-type ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (251 aa) |
| | atpC-2 | F0F1-type ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (130 aa) |
| | SYN_02097 | F0F1-type ATP synthase, beta subunit. (219 aa) |
| | SYN_02096 | F0F1-type ATP synthase, beta subunit. (260 aa) |
| | SYN_02093 | Hypothetical cytosolic protein. (230 aa) |
| | SYN_02081 | Phosphate butyryltransferase. (279 aa) |
| | SYN_02080 | Phosphate butyryltransferase. (310 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | SYN_02050 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (372 aa) |
| | SYN_02037 | Sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (217 aa) |
| | SYN_02030 | Colligrin; Belongs to the CinA family. (420 aa) |
| | SYN_02013 | Hypothetical cytosolic protein. (157 aa) |
| | dinB-2 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (362 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (453 aa) |
| | queF | Enzyme related to GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (140 aa) |
| | moaA-2 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | SYN_01958 | Molybdopterin converting factor, large subunit. (125 aa) |
| | SYN_01948 | Riboflavin kinase / FMN adenylyltransferase; Bifunctional; Belongs to the ribF family. (326 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (346 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (276 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (230 aa) |
| | trpB | Trytophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | SYN_01923 | Nif3-related protein. (252 aa) |
| | SYN_01896 | Glutamine amidotransferases class-II. (315 aa) |
| | SYN_01885 | Hypothetical cytosolic protein. (250 aa) |
| | SYN_01842 | Hypothetical cytosolic protein. (198 aa) |
| | SYN_01833 | hesA/moeB/thiF type protein. (1158 aa) |
| | SYN_01802 | Coproporphyrinogen oxidase (NAD). (432 aa) |
| | selA | L-seryl-tRNA(sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (474 aa) |
| | SYN_01800 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (333 aa) |
| | rho | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (415 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa) |
| | nusA | Transcription elongation factor; Participates in both transcription termination and antitermination. (420 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | SYN_01765 | DNA polymerase III, delta subunit. (460 aa) |
| | SYN_01752 | Isochorismate hydrolase. (78 aa) |
| | pdxT | Pyridoxine biosynthesis amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (224 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | fdhD-3 | Formate dehydrogenase activity protein; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (233 aa) |
| | fdhD-2 | Formate dehydrogenase activity protein; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (273 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (401 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1069 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (470 aa) |
| | SYN_01606 | Folylpolyglutamate synthase / dihydrofolate synthase; Bifunctional; Belongs to the folylpolyglutamate synthase family. (465 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (345 aa) |
| | queC | Queuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | queE | Queuosine biosynthesis protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa) |
| | SYN_01559 | Queuosine biosynthesis protein. (159 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (426 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | SYN_01522 | Thiamin pyrophosphokinase. (235 aa) |
| | SYN_01521 | Phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase; Bifunctional. (293 aa) |
| | thiC | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (427 aa) |
| | SYN_01495 | Hypothetical exported protein. (364 aa) |
| | SYN_01481 | Adenylate cyclase. (749 aa) |
| | SYN_01473 | Flagellum-specific ATP synthase. (455 aa) |
| | SYN_01443 | Hypothetical cytosolic protein. (274 aa) |
| | SYN_01420 | Hypothetical cytosolic protein. (509 aa) |
| | SYN_01415 | Hydrolase; HAD superfamily. (198 aa) |
| | SYN_01394 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (287 aa) |
| | pdxJ | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (254 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa) |
| | priA | Primosomal protein N' - superfamily II helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (809 aa) |
| | SYN_01314 | nucleotidyltransferase/DNA polymerase involved in DNA repair. (103 aa) |
| | folE2 | Hypothetical cytosolic protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (255 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (691 aa) |
| | SYN_01294 | Isochorismatase. (189 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (251 aa) |
| | rpoZ | RNA polymerase subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa) |
| | fdhD | Protein required for formate dehydrogenase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (253 aa) |
| | SYN_01231 | Cytidylate kinase. (231 aa) |
| | SYN_01224 | Metallo cofactor biosynthesis protein; moaA/nifB/pqqE family. (232 aa) |
| | acsA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa) |
| | SYN_01215 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (447 aa) |
| | SYN_01212 | Phosphate butyryltransferase. (307 aa) |
| | SYN_01211 | Phosphate butyryltransferase. (304 aa) |
| | SYN_01201 | Pyrazinamidase / nicotinamidase; Bifunctional. (130 aa) |
| | SYN_01177 | Metallo-beta-lactamase superfamily protein. (240 aa) |
| | SYN_01139 | Hypothetical cytosolic protein. (487 aa) |
| | SYN_01135 | Hypothetical cytosolic protein. (232 aa) |
| | SYN_01130 | dTDP-glucose 4,6-dehydratase. (331 aa) |
| | SYN_01112 | UDP-N-acetylglucosamine 4-epimerase. (339 aa) |
| | SYN_01073 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (176 aa) |
| | SYN_01004 | Protein involved in biosynthesis of molybdopterin. (116 aa) |
| | SYN_00945 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (487 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | SYN_00907 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (465 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | SYN_00896 | DNA polymerase III alpha subunit. (1155 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (347 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (223 aa) |
| | SYN_00878 | Hypothetical membrane protein. (64 aa) |
| | SYN_00842 | Uridylate kinase. (276 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (594 aa) |
| | rpoD | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (580 aa) |
| | SYN_00747 | Hypothetical exported protein. (373 aa) |
| | SYN_00729 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (570 aa) |
| | SYN_00697 | Hypothetical cytosolic protein. (500 aa) |
| | SYN_00694 | Pyruvate synthase delta subunit. (83 aa) |
| | SYN_00693 | Pyruvate synthase gamma chain. (175 aa) |
| | SYN_00692 | Pyruvate synthase alpha chain. (370 aa) |
| | SYN_00691 | Pyruvate synthase subunit. (304 aa) |
| | SYN_00684 | Phosphohydrolase; mutT/nudix family protein. (159 aa) |
| | SYN_00654 | Phosphate butyryltransferase. (305 aa) |
| | SYN_00653 | Phosphate butyryltransferase. (307 aa) |
| | SYN_00645 | Hypothetical cytosolic protein. (284 aa) |
| | SYN_00640 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (454 aa) |
| | SYN_00639 | RNA polymerase sigma-B factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (289 aa) |
| | SYN_00623 | Nicotinamide mononucleotide adenylyltransferase. (208 aa) |
| | SYN_00607 | Flavodoxin oxidoreductase. (278 aa) |
| | atpB | ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (217 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (322 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (432 aa) |
| | SYN_00582 | asnC family transcription regulatory protein. (180 aa) |
| | SYN_00578 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa) |
| | SYN_00576 | dTDP-4-dehydrorhamnose 3,5-epimerase. (151 aa) |
| | SYN_00565 | 2-amino-3-ketobutyrate coenzyme A ligase. (417 aa) |
| | dinB | nucleotidyltransferase/DNA polymerase protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (435 aa) |
| | atpF | ATP synthase B chain, sodium ion specific; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (163 aa) |
| | atpF1 | ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (202 aa) |
| | atpH | ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (181 aa) |
| | atpA1 | ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa) |
| | atpD | ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa) |
| | SYN_00532 | UDP-glucose 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (458 aa) |
| | SYN_00531 | UDP-D-glucuronate carboxy-lyase. (310 aa) |
| | SYN_00522 | Phosphoribosylformylglycinamidine synthase; Glutamine amidotransferase domain. (290 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (993 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (199 aa) |
| | SYN_00474 | Phosphoribosylaminoimidazole carboxylase NCAIR mutase subunit. (248 aa) |
| | thiE-2 | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (229 aa) |
| | SYN_00441 | thiS family protein. (67 aa) |
| | thiG | Thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa) |
| | SYN_00439 | thiH protein. (371 aa) |
| | SYN_00438 | thiF family protein. (210 aa) |
| | SYN_00426 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa) |
| | SYN_00424 | Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain; Catalyzes the oxidation of L-aspartate to iminoaspartate. (544 aa) |
| | SYN_00394 | Hypothetical cytosolic protein. (121 aa) |
| | SYN_00382 | Pyrophosphorylase ModD; Belongs to the NadC/ModD family. (307 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (345 aa) |
| | SYN_00357 | Predicted alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (531 aa) |
| | SYN_00348 | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (129 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (270 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (232 aa) |
| | SYN_00289 | Molybdopterin-guanine dinucleotide biosynthesis protein B. (169 aa) |
| | SYN_00286 | DNA polymerase IV; Family X. (584 aa) |
| | SYN_00275 | Radical SAM superfamily protein. (330 aa) |
| | SYN_00272 | Molybdopterin biosynthesis MoeA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (427 aa) |
| | SYN_00267 | Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (676 aa) |
| | SYN_00266 | Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (410 aa) |
| | SYN_00228 | Histidine kinase. (148 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (325 aa) |
| | cbiO | ABC-type cobalt transport system, ATPase component; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. (280 aa) |
| | SYN_00175 | Metal-dependent hydrolase. (279 aa) |
| | SYN_00157 | Pyruvate:ferredoxin oxidoreductase gamma subunit. (181 aa) |
| | SYN_00156 | Pyruvate:ferredoxin oxidoreductase delta subunit. (113 aa) |
| | SYN_00155 | Pyruvate:ferredoxin oxidoreductase alpha subunit. (391 aa) |
| | SYN_00154 | Pyruvate:ferredoxin oxidoreductase beta subunit. (323 aa) |
| | SYN_00124 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (351 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (439 aa) |
| | SYN_00107 | Phosphoribosylaminoimidazole-succinocarboxamide synthase. (238 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (448 aa) |
| | SYN_00101 | CrtK protein. (155 aa) |
| | nusG | Transcription antitermination protein; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | rpoB | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1363 aa) |
| | rpoC | DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1381 aa) |
| | SYN_00047 | Phosphorylase family 2 protein. (240 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (362 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (376 aa) |
| | SYN_00010 | ATPase. (397 aa) |
