STRINGSTRING
SYN_02852 SYN_02852 SYN_01515 SYN_01515 SYN_01549 SYN_01549 msbA msbA SYN_01633 SYN_01633 SYN_01635 SYN_01635 SYN_01666 SYN_01666 SYN_00590 SYN_00590 SYN_00610 SYN_00610 SYN_00640 SYN_00640 SYN_00745 SYN_00745 SYN_00774 SYN_00774 SYN_00778 SYN_00778 lon lon SYN_00785 SYN_00785 SYN_00786 SYN_00786 der der era era SYN_00824 SYN_00824 SYN_00839 SYN_00839 SYN_00853 SYN_00853 lolD lolD SYN_00946 SYN_00946 SYN_00955 SYN_00955 SYN_00973 SYN_00973 radA radA SYN_01702 SYN_01702 rho rho SYN_01809 SYN_01809 SYN_01844 SYN_01844 SYN_01888 SYN_01888 SYN_01899 SYN_01899 SYN_01904 SYN_01904 SYN_01978 SYN_01978 SYN_01990 SYN_01990 SYN_01994 SYN_01994 recA recA dnaA dnaA SYN_02065 SYN_02065 SYN_02069 SYN_02069 hslU hslU SYN_02171 SYN_02171 SYN_02172 SYN_02172 SYN_02214 SYN_02214 SYN_02224 SYN_02224 SYN_02378 SYN_02378 clpB clpB SYN_02530 SYN_02530 recD recD SYN_02572 SYN_02572 SYN_02585 SYN_02585 SYN_02656 SYN_02656 SYN_02713 SYN_02713 ftsH ftsH clpX clpX lon-2 lon-2 SYN_01511 SYN_01511 SYN_02899 SYN_02899 SYN_02956 SYN_02956 ruvB ruvB SYN_03153 SYN_03153 SYN_03206 SYN_03206 ftsH-2 ftsH-2 atpD atpD recD2 recD2 SYN_01054 SYN_01054 SYN_00569 SYN_00569 SYN_01090 SYN_01090 SYN_01093 SYN_01093 SYN_01122 SYN_01122 SYN_01181 SYN_01181 SYN_01191 SYN_01191 SYN_01263 SYN_01263 SYN_01274 SYN_01274 SYN_01404 SYN_01404 SYN_01426 SYN_01426 SYN_01459 SYN_01459 SYN_01460 SYN_01460 SYN_01466 SYN_01466 SYN_01473 SYN_01473 SYN_01497 SYN_01497 SYN_01506 SYN_01506 SYN_00024 SYN_00024 SYN_00051 SYN_00051 pstB pstB SYN_00079 SYN_00079 SYN_00125 SYN_00125 SYN_00126 SYN_00126 dnaX dnaX cbiO cbiO SYN_00216 SYN_00216 SYN_00241 SYN_00241 SYN_00242 SYN_00242 SYN_00271 SYN_00271 SYN_00283 SYN_00283 SYN_00329 SYN_00329 SYN_00367 SYN_00367 SYN_00397 SYN_00397 SYN_00410 SYN_00410 SYN_00458 SYN_00458 SYN_00466 SYN_00466
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYN_02852ATP-dependent helicase. (1282 aa)
SYN_01515ATPase; AAA+ superfamily. (423 aa)
SYN_01549General secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (554 aa)
msbAPhospholipid-lipopolysaccharide ABC transporter; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (601 aa)
SYN_01633Nif-specific regulatory protein with sigma 54 interaction domain. (513 aa)
SYN_01635Sigma-54 dependent transcription regulator. (450 aa)
SYN_01666Antibiotic export ATP-binding protein. (261 aa)
SYN_00590Two-component system response regulator. (485 aa)
SYN_00610ATP-binding protein. (538 aa)
SYN_00640Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (454 aa)
SYN_00745ABC transporter ATP-binding protein. (271 aa)
SYN_00774ABC transporter ATP-binding protein. (314 aa)
SYN_00778General secretion pathway protein A. (366 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (790 aa)
SYN_00785Branched-chain amino acid transport ATP-binding protein. (235 aa)
SYN_00786Branched-chain amino acid transport ATP-binding protein. (265 aa)
derGTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (447 aa)
eraGTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (306 aa)
SYN_00824ABC transporter ATP-binding protein. (428 aa)
SYN_00839Tungsten transporter ATP binding protein; Belongs to the ABC transporter superfamily. (365 aa)
SYN_00853ABC transporter ATP-binding commponent. (237 aa)
lolDLipoprotein releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (223 aa)
SYN_00946ABC transporter ATP-binding protein. (240 aa)
SYN_00955ABC-type Mn/Zn transport system ATPase component. (258 aa)
SYN_00973Sigma-54 dependent transcriptional regulator. (472 aa)
radADNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (538 aa)
SYN_01702Response regulator with sigma 54 interaction domain. (502 aa)
rhoTranscription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (415 aa)
SYN_01809Sigma-54-dependent transcriptional regulator. (443 aa)
SYN_01844Hypothetical cytosolic protein. (592 aa)
SYN_01888ATPase components of ABC transporters with duplicated ATPase domains. (501 aa)
SYN_01899istB-like ATP binding protein. (255 aa)
SYN_01904ATPases of the AAA family. (373 aa)
SYN_01978ABC transporter ATP-binding protein. (561 aa)
SYN_01990ATPase, AAA family. (478 aa)
SYN_01994ABC transporter ATP-binding protein. (244 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (343 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (457 aa)
SYN_02065Export ABC transporter ATP-binding protein / export ABC transporter permease protein. (931 aa)
SYN_02069ABC-type transport system involved in resistance to organic solvents, ATPase component. (264 aa)
hslUATP-dependent endopeptidase hsl ATP-binding subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (460 aa)
SYN_02171Oligopeptide transport ATP-binding protein; Belongs to the ABC transporter superfamily. (327 aa)
SYN_02172Oligopeptide transport ATP-binding protein; Belongs to the ABC transporter superfamily. (338 aa)
SYN_02214Response regulator with sigma 54 interaction domain. (452 aa)
SYN_02224ABC-type phosphate transport system, ATPase component; Belongs to the ABC transporter superfamily. (237 aa)
SYN_02378ATPase clp protease ATP binding subunit; Belongs to the ClpA/ClpB family. (768 aa)
clpBclpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (874 aa)
SYN_02530Two-component response regulator. (456 aa)
recDExodeoxyribonuclease V alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (670 aa)
SYN_02572moxR-like ATPase with AAA domain. (283 aa)
SYN_02585Transcrption factor sigma 54 type. (555 aa)
SYN_02656ABC-type polysaccharide/polyol phosphate transport protein, ATPase component. (455 aa)
SYN_02713Response regulator containing sigma 54 interaction domain. (457 aa)
ftsHCell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (611 aa)
clpXATP-dependent clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (420 aa)
lon-2ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (812 aa)
SYN_01511ATPase; AAA+ superfamily. (442 aa)
SYN_02899Transcriptional regulator with sigma 54 interaction domain. (592 aa)
SYN_02956Transcriptional regulator containing sigma 54 interaction domain. (697 aa)
ruvBHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa)
SYN_03153ATPase related to magnesium chelatase subunit. (509 aa)
SYN_03206ABC transporter ATP-binding protein. (266 aa)
ftsH-2Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (736 aa)
atpDATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa)
recD2Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (753 aa)
SYN_01054iron(III) dicitrate transport ATP-binding protein. (288 aa)
SYN_00569Predicted ATPase protein with chaperone activity. (494 aa)
SYN_01090Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains. (535 aa)
SYN_01093Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (456 aa)
SYN_01122Transcriptional regulator, sigma-54-dependent. (645 aa)
SYN_01181Transcriptional regulator with sigma 54 interaction domain. (455 aa)
SYN_01191Transcriptional regulator with sigma 54 interaction domain. (455 aa)
SYN_01263ABC-type transport system involved in resistance to organic solvents, ATPase component. (413 aa)
SYN_01274Cell division protein. (733 aa)
SYN_01404General secretion pathway protein E. (784 aa)
SYN_01426ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component. (278 aa)
SYN_01459Export ABC transporter ATP-binding protein. (266 aa)
SYN_01460Export ABC transporter ATP-binding protein. (270 aa)
SYN_01466Sigma-54 dependent transcriptional regulator. (473 aa)
SYN_01473Flagellum-specific ATP synthase. (455 aa)
SYN_01497Flp pilus assembly protein, ATPase. (442 aa)
SYN_01506ATPase; AAA+ superfamily. (464 aa)
SYN_00024ABC transporter ATP-binding protein. (239 aa)
SYN_00051Predicted ATPase with chaperone activity. (467 aa)
pstBABC-type phosphate transport system, ATPase component; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (256 aa)
SYN_00079ABC-type sugar transport systems, ATPase component; Belongs to the ABC transporter superfamily. (421 aa)
SYN_00125Pili retraction protein. (360 aa)
SYN_00126Pili retraction protein. (404 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (588 aa)
cbiOABC-type cobalt transport system, ATPase component; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. (280 aa)
SYN_00216ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (266 aa)
SYN_00241Export ABC transporter ATP-binding protein. (310 aa)
SYN_00242Export ABC transporter ATP-binding protein. (309 aa)
SYN_00271ABC-type molybdate transport system, ATPase component; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (351 aa)
SYN_00283ABC transporter ATP-binding protein. (235 aa)
SYN_00329ATP-dependent protease subunit. (315 aa)
SYN_00367Sulfate transport ATP-binding protein. (262 aa)
SYN_00397ATP binding protein. (255 aa)
SYN_00410ABC-type transport system, ATP-binding component. (248 aa)
SYN_00458General secretion pathway protein E. (558 aa)
SYN_00466ABC transporter ATP-binding protein. (675 aa)
Your Current Organism:
Syntrophus aciditrophicus
NCBI taxonomy Id: 56780
Other names: S. aciditrophicus SB, Syntrophus aciditrophicus SB, Syntrophus aciditrophicus str. SB, Syntrophus aciditrophicus strain SB
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