STRINGSTRING
mobB mobB mobA mobA GCA_000406125_00043 GCA_000406125_00043 GCA_000406125_00044 GCA_000406125_00044 thiH thiH thiG thiG thiS thiS GCA_000406125_00208 GCA_000406125_00208 thiE thiE thiC thiC GCA_000406125_00953 GCA_000406125_00953 GCA_000406125_00954 GCA_000406125_00954 GCA_000406125_00955 GCA_000406125_00955 GCA_000406125_00956 GCA_000406125_00956 csdE csdE csdA csdA thiI thiI modF modF modE modE acrZ acrZ modA modA modB modB modC modC moeB moeB moeA moeA moaA moaA moaB moaB moaC moaC moaD moaD moaE moaE sufE sufE sufS sufS GCA_000406125_02268 GCA_000406125_02268 thiD thiD iscX iscX fdx fdx hscA hscA hscB hscB iscA iscA iscU iscU iscS iscS iscR iscR erpA erpA clcA clcA GCA_000406125_03086 GCA_000406125_03086 nsrR nsrR djlA djlA GCA_000406125_03408 GCA_000406125_03408 GCA_000406125_03409 GCA_000406125_03409 GCA_000406125_03613 GCA_000406125_03613 nfuA nfuA cyaY cyaY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mobBUnannotated protein. (176 aa)
mobAUnannotated protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (191 aa)
GCA_000406125_00043Unannotated protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
GCA_000406125_00044Unannotated protein. (214 aa)
thiHUnannotated protein. (382 aa)
thiGUnannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)
thiSUnannotated protein. (66 aa)
GCA_000406125_00208Unannotated protein. (249 aa)
thiEUnannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
thiCUnannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (653 aa)
GCA_000406125_00953Unannotated protein. (81 aa)
GCA_000406125_00954Unannotated protein. (138 aa)
GCA_000406125_00955Unannotated protein. (318 aa)
GCA_000406125_00956Unannotated protein. (362 aa)
csdEUnannotated protein. (147 aa)
csdAUnannotated protein. (401 aa)
thiIUnannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
modFUnannotated protein. (489 aa)
modEUnannotated protein. (263 aa)
acrZUnannotated protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)
modAUnannotated protein. (261 aa)
modBUnannotated protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa)
modCUnannotated protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
moeBUnannotated protein. (252 aa)
moeAUnannotated protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa)
moaAUnannotated protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (340 aa)
moaBUnannotated protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
moaCUnannotated protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa)
moaDUnannotated protein. (81 aa)
moaEUnannotated protein. (150 aa)
sufEUnannotated protein. (138 aa)
sufSUnannotated protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (407 aa)
GCA_000406125_02268Unannotated protein. (732 aa)
thiDUnannotated protein. (267 aa)
iscXUnannotated protein. (66 aa)
fdxUnannotated protein. (111 aa)
hscAUnannotated protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa)
hscBUnannotated protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (179 aa)
iscAUnannotated protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa)
iscUUnannotated protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
iscSUnannotated protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)
iscRUnannotated protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (164 aa)
erpAUnannotated protein; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
clcAUnannotated protein. (465 aa)
GCA_000406125_03086Unannotated protein. (255 aa)
nsrRUnannotated protein; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
djlAUnannotated protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (319 aa)
GCA_000406125_03408Unannotated protein. (149 aa)
GCA_000406125_03409Unannotated protein. (49 aa)
GCA_000406125_03613Unannotated protein. (349 aa)
nfuAUnannotated protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa)
cyaYUnannotated protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa)
Your Current Organism:
Dickeya sp. NCPPB569
NCBI taxonomy Id: 568768
Other names: D. sp. NCPPB 569, Dickeya sp. NCPPB 569
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