(37 nodes) Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor network (Acidaminococcus intestini)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ldh-2	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (317 aa)
	aroE	Shikimate dehydrogenase; COG1605. (277 aa)
	aroE-2	Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
	apbA	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (316 aa)
	ribD	Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
	ugd	UDPglucose 6-dehydrogenase; COG1004. (411 aa)
	Acin_0487	Conserved hypothetical protein; COG1979. (415 aa)
	ldh	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (319 aa)
	ttuC	Tartrate dehydrogenase; COG0473. (359 aa)
	Acin_0639	Conserved hypothetical protein. (313 aa)
	paaH	3-hydroxybutyryl-CoA dehydrogenase; COG1250. (285 aa)
	wbpO	Nucleotide sugar dehydrogenase; COG0677; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (443 aa)
	apbA-2	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (324 aa)
	Acin_0870	Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
	hisD	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (448 aa)
	rfbD	dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (309 aa)
	adhE-2	Acetaldehyde dehydrogenase / alcohol dehydrogenase; COG1454. (405 aa)
	guaB	IMP dehydrogenase; COG0517. (503 aa)
	Acin_1162	Homoserine dehydrogenase; COG0460. (433 aa)
	gpsA	Isopentenyl-diphosphate delta-isomerase; COG0240; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (331 aa)
	icd	Isocitrate dehydrogenase; COG0473. (392 aa)
	ldhA	D-lactate dehydrogenase; COG1052; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
	paaH-2	3-hydroxybutyryl-CoA dehydrogenase. (303 aa)
	murB	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (311 aa)
	Acin_1438	Riboflavin biosynthesis protein ribD. (240 aa)
	sfcA	Malolactic enzyme; COG0281. (542 aa)
	murB-2	UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (305 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa)
	serA	D-isomer specific 2-hydroxyacid dehydrogenase. (318 aa)
	dxr	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (386 aa)
	sfcA-2	Malate dehydrogenase; COG0281. (423 aa)
	Acin_1746	Conserved hypothetical protein. (384 aa)
	Acin_2019	Conserved hypothetical protein; COG1979. (395 aa)
	Acin_2087	Isocitrate dehydrogenase; COG0538; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (459 aa)
	Acin_2362	Conserved hypothetical protein. (368 aa)
	serA-2	D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (550 aa)

Your Current Organism:

Acidaminococcus intestini

NCBI taxonomy Id: 568816
Other names: A. intestini RyC-MR95, Acidaminococcus intestini RyC-MR95, Acidaminococcus intestini strain RyC-MR95

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acin_0487	ugd	Acin_0487	Acin_0486	Conserved hypothetical protein; COG1979.	UDPglucose 6-dehydrogenase; COG1004.	0.709
Acin_1162	gpsA	Acin_1162	Acin_1164	Homoserine dehydrogenase; COG0460.	Isopentenyl-diphosphate delta-isomerase; COG0240; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	0.585
Acin_1162	guaB	Acin_1162	Acin_1075	Homoserine dehydrogenase; COG0460.	IMP dehydrogenase; COG0517.	0.429
Acin_1162	ilvC	Acin_1162	Acin_0110	Homoserine dehydrogenase; COG0460.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.473
Acin_1162	serA	Acin_1162	Acin_1570	Homoserine dehydrogenase; COG0460.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.434
Acin_1162	serA-2	Acin_1162	Acin_2394	Homoserine dehydrogenase; COG0460.	D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.456
Acin_1438	guaB	Acin_1438	Acin_1075	Riboflavin biosynthesis protein ribD.	IMP dehydrogenase; COG0517.	0.415
Acin_2087	icd	Acin_2087	Acin_1202	Isocitrate dehydrogenase; COG0538; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Isocitrate dehydrogenase; COG0473.	0.937
Acin_2087	ldh	Acin_2087	Acin_0505	Isocitrate dehydrogenase; COG0538; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.787
Acin_2087	ldh-2	Acin_2087	Acin_2417	Isocitrate dehydrogenase; COG0538; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.	0.787
apbA	apbA-2	Acin_0325	Acin_0864	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	0.928
apbA-2	apbA	Acin_0864	Acin_0325	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	0.928
aroE	aroE-2	Acin_0030	Acin_0035	Shikimate dehydrogenase; COG1605.	Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	0.939
aroE-2	aroE	Acin_0035	Acin_0030	Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Shikimate dehydrogenase; COG1605.	0.939
gpsA	Acin_1162	Acin_1164	Acin_1162	Isopentenyl-diphosphate delta-isomerase; COG0240; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Homoserine dehydrogenase; COG0460.	0.585
guaB	Acin_1162	Acin_1075	Acin_1162	IMP dehydrogenase; COG0517.	Homoserine dehydrogenase; COG0460.	0.429
guaB	Acin_1438	Acin_1075	Acin_1438	IMP dehydrogenase; COG0517.	Riboflavin biosynthesis protein ribD.	0.415
guaB	icd	Acin_1075	Acin_1202	IMP dehydrogenase; COG0517.	Isocitrate dehydrogenase; COG0473.	0.522
guaB	ldh	Acin_1075	Acin_0505	IMP dehydrogenase; COG0517.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.464
guaB	ldh-2	Acin_1075	Acin_2417	IMP dehydrogenase; COG0517.	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.	0.464