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| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (934 aa) |
| | metB | Cystathionine gamma-lyase; COG0626. (378 aa) |
| | Acin_2087 | Isocitrate dehydrogenase; COG0538; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (459 aa) |
| | pgi | Glucose-6-phosphate isomerase. (479 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD | Ornithine/acetylornithine aminotransferase; COG4992; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (396 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argG | Argininosuccinate synthase; COG0137; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa) |
| | argH | Argininosuccinate lyase; COG0165. (470 aa) |
| | dapE-2 | Peptidase. (423 aa) |
| | Acin_2046 | Conserved hypothetical protein; Belongs to the UPF0597 family. (446 aa) |
| | gltD | Glutamate synthase (NADPH/NADH) small chain; COG0493. (459 aa) |
| | Acin_2034 | Gamma-aminobutyrate metabolism dehydratase/isomerase; COG2368. (473 aa) |
| | Acin_2001 | Conserved hypothetical protein; NOG73630. (103 aa) |
| | Acin_1883 | rRNA biogenesis protein rrp5, putative. (103 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (381 aa) |
| | glcD-2 | FAD-linked oxidase. (466 aa) |
| | Acin_1781 | Conserved hypothetical protein. (105 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | Acin_1702 | Conserved hypothetical protein; NOG27680. (214 aa) |
| | aroF | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (346 aa) |
| | Acin_1683 | Chaperone hchA; COG0693. (297 aa) |
| | lysA | Diaminopimelate decarboxylase; COG0019. (424 aa) |
| | pyk | Pyruvate kinase; COG3848; Belongs to the pyruvate kinase family. (611 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein plsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (336 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase; COG0331. (315 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (89 aa) |
| | fabF | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (418 aa) |
| | Acin_1616 | Conserved hypothetical protein. (402 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (386 aa) |
| | gcpE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (356 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa) |
| | Acin_1582 | Amidohydrolase; COG1473; Belongs to the peptidase M20A family. (392 aa) |
| | Acin_1574 | Glutamine amidotransferase. (327 aa) |
| | gudD | Glucarate dehydratase; COG4948; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (442 aa) |
| | Acin_0831 | Conserved hypothetical protein; COG1304. (342 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (539 aa) |
| | argS | arginyl-tRNA synthetase; COG0018. (552 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (124 aa) |
| | thrC | Threonine synthase; COG0498. (489 aa) |
| | Acin_0749 | Conserved hypothetical protein. (282 aa) |
| | Acin_0745 | Conserved hypothetical protein. (199 aa) |
| | crt | enoyl-CoA hydratase/carnithine racemase; COG1024; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa) |
| | paaH | 3-hydroxybutyryl-CoA dehydrogenase; COG1250. (285 aa) |
| | Acin_0720 | acyl-CoA dehydrogenase; COG1960. (384 aa) |
| | atoB | acetyl-CoA acetyltransferase; COG0183; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | hipO | Amidohydrolase; COG1473. (385 aa) |
| | Acin_0715 | Diaminopropionate ammonia-lyase; COG1171. (391 aa) |
| | Acin_0673 | Conserved hypothetical protein. (48 aa) |
| | mtnN | Nucleoside phosphorylase. (247 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa) |
| | hisS | histidyl-tRNA synthetase; COG0124. (428 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877; Belongs to the KdsA family. (273 aa) |
| | korB | Ketoisovalerate oxidoreductase subunit vorA. (246 aa) |
| | Acin_0614 | L-lactate oxidase; COG1304. (362 aa) |
| | ltaA | Threonine aldolase; COG2008. (341 aa) |
| | Acin_0586 | Dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (412 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (99 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (885 aa) |
| | Acin_0561 | Conserved hypothetical protein. (221 aa) |
| | ttuC | Tartrate dehydrogenase; COG0473. (359 aa) |
| | ilvA | Threonine dehydratase; COG1171. (404 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa) |
| | leuS | leucyl-tRNA synthetase; COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. (830 aa) |
| | Acin_0509 | Hypothetical protein. (120 aa) |
| | Acin_0506 | Fumarylacetoacetate hydrolase; COG0179. (289 aa) |
| | ldh | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (319 aa) |
| | bcd-2 | butyryl-CoA dehydrogenase; COG2025. (591 aa) |
| | ugd | UDPglucose 6-dehydrogenase; COG1004. (411 aa) |
| | bcd | acyl-CoA dehydrogenase; COG1960. (377 aa) |
| | glnA | Glutamine synthetase; COG0174; Belongs to the glutamine synthetase family. (632 aa) |
| | Acin_0440 | Conserved hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (472 aa) |
| | Acin_0412 | Aminotransferase. (416 aa) |
| | sufS | Cysteine desulfurase / selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (406 aa) |
| | yciA | Thioesterase. (130 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (316 aa) |
| | Acin_0324 | Amidohydrolase. (418 aa) |
| | Acin_0321 | Benzoyl-CoA reductase. (379 aa) |
| | Acin_0320 | 2-hydroxyglutaryl-CoA dehydratase D-component; COG1775. (477 aa) |
| | Acin_0319 | Conserved hypothetical protein; COG1924. (260 aa) |
| | Acin_0318 | glutaconyl-CoA decarboxylase subunit alpha; COG4799. (586 aa) |
| | gctB | Glutaconate CoA-transferase subunit B; COG2057. (267 aa) |
| | gctA | Glutaconate CoA-transferase subunit A; COG1788. (315 aa) |
| | oadB | glutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (376 aa) |
| | mmdC | glutaconyl-CoA decarboxylase subunit gamma; COG0511. (145 aa) |
| | Acin_0296 | glutaconyl-CoA decarboxylase subunit delta; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (108 aa) |
| | pccB | Carboxyl transferase; COG4799. (508 aa) |
| | hutI | Imidazolonepropionase; COG1228. (416 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (682 aa) |
| | hutH | Histidine ammonia-lyase; COG2986. (520 aa) |
| | Acin_0285 | Histidine ammonia-lyase. (508 aa) |
| | Acin_0279 | Glutamate formiminotransferase; COG3643. (301 aa) |
| | Acin_0270 | Acetylornithine deacetylase. (369 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | adh | Alcohol dehydrogenase; COG1063. (352 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (364 aa) |
| | speB | Agmatinase; Belongs to the arginase family. (321 aa) |
| | speC | Lysine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (365 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (424 aa) |
| | glcD | FAD-linked oxidase. (467 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; COG0115. (341 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (273 aa) |
| | Acin_0170 | 3-methylitaconate isomerase. (385 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; COG0161; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (228 aa) |
| | Acin_0142 | Peptidase M20D; Belongs to the peptidase M20A family. (396 aa) |
| | ilvD | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (550 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ilvH | Acetolactate synthase 3 regulatory subunit; COG0440. (166 aa) |
| | Acin_0053 | Conserved hypothetical protein; COG1473; Belongs to the peptidase M20A family. (442 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (251 aa) |
| | prpB | Carboxyvinyl-carboxyphosphonate phosphorylmutase. (289 aa) |
| | aroE-2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa) |
| | hmgL | hydroxymethylglutaryl-CoA lyase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (315 aa) |
| | aroK | Shikimate kinase/3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa) |
| | aroE | Shikimate dehydrogenase; COG1605. (277 aa) |
| | pheA | Chorismate mutase; COG0077. (282 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (425 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | Acin_0025 | Prephenate dehydrogenase tyrA. (288 aa) |
| | aroA | Phospho-2-dehydro-3-deoxyheptonate aldolase; COG2876. (337 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (309 aa) |
| | Acin_0016 | acyl-CoA hydrolase. (155 aa) |
| | serA | D-isomer specific 2-hydroxyacid dehydrogenase. (318 aa) |
| | korB-2 | 2-oxoglutarate ferredoxin oxidoreductase subunit beta; COG1013. (271 aa) |
| | edd | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (564 aa) |
| | Acin_1562 | acetyl-CoA hydrolase/transferase. (439 aa) |
| | Acin_1552 | Propionate catabolism protein. (450 aa) |
| | Acin_1547 | Conserved hypothetical protein; COG0454. (126 aa) |
| | bioB-2 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (315 aa) |
| | garD | Galactarate dehydratase; COG2721. (522 aa) |
| | bioB | Radical SAM family protein. (352 aa) |
| | pgk | Phosphoglycerate kinase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (641 aa) |
| | gpm-2 | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | glmS | Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | Acin_1462 | Beta-lactamase domain protein; COG2220; Belongs to the UPF0173 family. (239 aa) |
| | folP | Dihydropteroate synthase; COG0294. (382 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801. (150 aa) |
| | Acin_1454 | Hypothetical protein. (241 aa) |
| | Acin_1451 | Amidohydrolase; COG1473. (432 aa) |
| | guaA | Bifunctional GMP synthase/glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. (515 aa) |
| | Acin_1448 | 2,5-didehydrogluconate reductase; COG0656. (86 aa) |
| | mmuM | Homocysteine methyltransferase; COG2040. (320 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (307 aa) |
| | Acin_1365 | Conserved hypothetical protein; NOG73630. (103 aa) |
| | Acin_1273 | Quinone oxidoreductase; COG0604. (326 aa) |
| | paaH-2 | 3-hydroxybutyryl-CoA dehydrogenase. (303 aa) |
| | panD | Aspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa) |
| | Acin_1204 | Conserved hypothetical protein; COG2828. (381 aa) |
| | icd | Isocitrate dehydrogenase; COG0473. (392 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (874 aa) |
| | Acin_1171 | FAD dependent oxidoreductase; COG2081. (414 aa) |
| | rpsA | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (635 aa) |
| | Acin_1162 | Homoserine dehydrogenase; COG0460. (433 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa) |
| | Acin_1152 | Peptidase. (385 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | lysC | Aspartate kinase; COG0527; Belongs to the aspartokinase family. (410 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | fbaA | Fructose-1,6-bisphosphate aldolase; COG0191. (301 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (150 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (598 aa) |
| | Acin_1090 | 3-isopropylmalate dehydratase large subunit. (369 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (480 aa) |
| | trpS | tryptophanyl-tRNA synthetase; COG0180; Belongs to the class-I aminoacyl-tRNA synthetase family. (353 aa) |
| | Acin_1054 | Oxidoreductase; COG0656. (293 aa) |
| | Acin_1049 | Amidohydrolase; COG1228. (382 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (644 aa) |
| | carB | Carbamoyl-phosphate synthase; COG0458; Belongs to the CarB family. (1068 aa) |
| | carA | Carbamoyl-phosphate synthase; COG0505; Belongs to the CarA family. (359 aa) |
| | pyrB | Aspartate carbamoyltransferase; COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (318 aa) |
| | Acin_1009 | Conserved hypothetical protein; NOG13551. (314 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (240 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase. (173 aa) |
| | Acin_0992 | Histidinol-phosphate aminotransferase. (103 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (811 aa) |
| | pheS | phenylalanyl-tRNA synthetase subunit alpha; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (341 aa) |
| | cysS | cysteinyl-tRNA synthetase; COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. (474 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (490 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (394 aa) |
| | Acin_0942 | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa) |
| | Acin_0907 | butyryl-CoA transferase; COG0427. (449 aa) |
| | yarS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (408 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1143 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (674 aa) |
| | hisIE | phosphoribosyl-AMP cyclohydrolase; COG0140; In the N-terminal section; belongs to the PRA-CH family. (222 aa) |
| | hisF | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG0106. (245 aa) |
| | hisH | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | hisB-2 | Imidazoleglycerol phosphate dehydratase; COG0131; Belongs to the imidazoleglycerol-phosphate dehydratase family. (113 aa) |
| | hisB | Imidazoleglycerol phosphate dehydratase; COG0131; Belongs to the imidazoleglycerol-phosphate dehydratase family. (73 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (384 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (448 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (390 aa) |
| | lysS | lysyl-tRNA synthetase class II; COG1190; Belongs to the class-II aminoacyl-tRNA synthetase family. (657 aa) |
| | Acin_0870 | Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | Acin_0867 | Peptidase M20. (449 aa) |
| | apbA-2 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (324 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | Acin_2457 | Glutamine amidotransferase. (249 aa) |
| | Acin_2453 | Glutamine amidotransferase; COG2071. (249 aa) |
| | Acin_2442 | Conserved hypothetical protein; COG0620. (372 aa) |
| | kbl | 8-amino-7-oxononanoate synthase; COG0156. (408 aa) |
| | ansA | L-asparaginase. (337 aa) |
| | Acin_2420 | Amidohydrolase; COG1473. (477 aa) |
| | ldh-2 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (317 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | leuD | Homoaconitase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (580 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | serA-2 | D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (550 aa) |
| | glsA | Glutaminase; COG2066; Belongs to the glutaminase family. (310 aa) |
| | metY | O-acetylhomoserine (thiol)-lyase; COG2873. (431 aa) |
| | murQ | N-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (278 aa) |
| | Acin_2302 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (260 aa) |
| | dapA-2 | Dihydrodipicolinate synthetase; COG0329; Belongs to the DapA family. (323 aa) |
| | Acin_2282 | Peptidase. (368 aa) |
| | Acin_2280 | Amidohydrolase; COG1473; Belongs to the peptidase M20A family. (400 aa) |
| | Acin_2275 | Hypothetical protein. (401 aa) |
| | Acin_2274 | Hypothetical protein. (134 aa) |
| | edd-2 | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (547 aa) |
| | metF | Methylenetetrahydrofolate reductase (NADPH); COG0685; Belongs to the methylenetetrahydrofolate reductase family. (288 aa) |
| | Acin_2233 | Conserved hypothetical protein. (231 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase. (803 aa) |
| | Acin_2231 | Glutamine amidotransferase; COG2071. (248 aa) |
| | bioB-3 | Fe-hydrogenase assembly protein; COG0502. (373 aa) |
| | Acin_2228 | Conserved hypothetical protein; COG0620. (370 aa) |
| | glcD-3 | FAD linked oxidase domain protein; COG0277. (473 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (366 aa) |
| | Acin_2206 | Conserved hypothetical protein; Belongs to the UPF0597 family. (436 aa) |
| | Acin_2205 | Amidohydrolase. (391 aa) |
| | Acin_2195 | Amidohydrolase. (395 aa) |
| | Acin_2194 | Conserved hypothetical protein. (373 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; COG0134; Belongs to the TrpC family. (261 aa) |
| | trpF | Anthranilate synthase component II; COG0135; Belongs to the TrpF family. (210 aa) |
| | trpB | Tryptophan synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (257 aa) |
| | Acin_2162 | Conserved hypothetical protein. (390 aa) |
| | glyQ | glycine-tRNA ligase; COG0752. (292 aa) |
| | glyS | Metal-dependent phosphohydrolase; COG0751. (686 aa) |
