(14 nodes) Dihydrolipoyl dehydrogenase complex, and Pyruvate dehydrogenase complex network (Cladophialophora immunda)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV07_10776	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (333 aa)
	PV07_09247	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (498 aa)
	PV07_08143	Dihydrolipoyl dehydrogenase. (516 aa)
	PV07_10155	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (408 aa)
	PV07_05986	Lipoyl-binding domain-containing protein. (446 aa)
	PV07_08038	Lipoyl-binding domain-containing protein. (468 aa)
	PV07_09102	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component. (1051 aa)
	PV07_04136	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	PV07_04423	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (376 aa)
	PV07_06642	Uncharacterized protein. (464 aa)
	PV07_01420	Transket_pyr domain-containing protein. (392 aa)
	PV07_01281	Uncharacterized protein. (528 aa)
	PV07_01422	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (495 aa)
	PV07_01421	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (447 aa)

Your Current Organism:

Cladophialophora immunda

NCBI taxonomy Id: 569365
Other names: C. immunda, CBS 834.96, Cladophialophora sp. CBS 834.96, Cladophialophora sp. HB-2008

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV07_01281	PV07_01420	A0A0D2CXF4	A0A0D2CU11	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.952
PV07_01281	PV07_01421	A0A0D2CXF4	A0A0D2DG08	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.906
PV07_01281	PV07_01422	A0A0D2CXF4	A0A0D2CXN9	Uncharacterized protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.951
PV07_01281	PV07_04136	A0A0D2CXF4	A0A0D2CRN5	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.944
PV07_01281	PV07_04423	A0A0D2CXF4	A0A0D2CSH3	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.995
PV07_01281	PV07_05986	A0A0D2CXF4	A0A0D2AY49	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.960
PV07_01281	PV07_06642	A0A0D2CXF4	A0A0D2CTA9	Uncharacterized protein.	Uncharacterized protein.	0.983
PV07_01281	PV07_08038	A0A0D2CXF4	A0A0D2CBD9	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.960
PV07_01281	PV07_09102	A0A0D2CXF4	A0A0D2CQV7	Uncharacterized protein.	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component.	0.984
PV07_01281	PV07_09247	A0A0D2CXF4	A0A0D1ZEH8	Uncharacterized protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.993
PV07_01281	PV07_10155	A0A0D2CXF4	A0A0D2AHS6	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.982
PV07_01281	PV07_10776	A0A0D2CXF4	A0A0D1ZBL1	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.837
PV07_01420	PV07_01281	A0A0D2CU11	A0A0D2CXF4	Transket_pyr domain-containing protein.	Uncharacterized protein.	0.952
PV07_01420	PV07_01421	A0A0D2CU11	A0A0D2DG08	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.998
PV07_01420	PV07_01422	A0A0D2CU11	A0A0D2CXN9	Transket_pyr domain-containing protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.971
PV07_01420	PV07_04136	A0A0D2CU11	A0A0D2CRN5	Transket_pyr domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.505
PV07_01420	PV07_04423	A0A0D2CU11	A0A0D2CSH3	Transket_pyr domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.688
PV07_01420	PV07_05986	A0A0D2CU11	A0A0D2AY49	Transket_pyr domain-containing protein.	Lipoyl-binding domain-containing protein.	0.936
PV07_01420	PV07_06642	A0A0D2CU11	A0A0D2CTA9	Transket_pyr domain-containing protein.	Uncharacterized protein.	0.933
PV07_01420	PV07_08038	A0A0D2CU11	A0A0D2CBD9	Transket_pyr domain-containing protein.	Lipoyl-binding domain-containing protein.	0.933