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PV07_01176 PV07_01176 PV07_03340 PV07_03340 PV07_03533 PV07_03533 PV07_03571 PV07_03571 PV07_03989 PV07_03989 PV07_04127 PV07_04127 PV07_00591 PV07_00591 PV07_00933 PV07_00933 PV07_01839 PV07_01839 PV07_02327 PV07_02327 PV07_12474 PV07_12474 PV07_12328 PV07_12328 PV07_11039 PV07_11039 PV07_11123 PV07_11123 PV07_11243 PV07_11243 PV07_11465 PV07_11465 PV07_11681 PV07_11681 PV07_11761 PV07_11761 COQ3 COQ3 PV07_12056 PV07_12056 PV07_10015 PV07_10015 PV07_10059 PV07_10059 PV07_09938 PV07_09938 PV07_10829 PV07_10829 PV07_10139 PV07_10139 PV07_10172 PV07_10172 PV07_10486 PV07_10486 PV07_10631 PV07_10631 PV07_08995 PV07_08995 PV07_08442 PV07_08442 PV07_09192 PV07_09192 PV07_09284 PV07_09284 PV07_08871 PV07_08871 PV07_08939 PV07_08939 PV07_06552 PV07_06552 PV07_09435 PV07_09435 PV07_07102 PV07_07102 PV07_06588 PV07_06588 PV07_07286 PV07_07286 PV07_07136 PV07_07136 PV07_07278 PV07_07278 PV07_07314 PV07_07314 PV07_07323 PV07_07323 PV07_07350 PV07_07350 PV07_07519 PV07_07519 PV07_08366 PV07_08366 PV07_04809 PV07_04809 PV07_04877 PV07_04877 PV07_12338 PV07_12338 PV07_05977 PV07_05977 PV07_06014 PV07_06014 PV07_10973 PV07_10973 PV07_05208 PV07_05208 PV07_05308 PV07_05308 PV07_06309 PV07_06309 PV07_05519 PV07_05519 PV07_05544 PV07_05544 PV07_05690 PV07_05690 PV07_11532 PV07_11532 PV07_05786 PV07_05786 PV07_02788 PV07_02788 PV07_05955 PV07_05955 PV07_05969 PV07_05969 PV07_11883 PV07_11883 PV07_03083 PV07_03083 PV07_06164 PV07_06164 PV07_03405 PV07_03405 PV07_03457 PV07_03457 PV07_10258 PV07_10258 PV07_10448 PV07_10448 PV07_02977 PV07_02977 PV07_04291 PV07_04291 PV07_04549 PV07_04549 PV07_04583 PV07_04583 PV07_08938 PV07_08938 PV07_00290 PV07_00290 PV07_08984 PV07_08984 PV07_00305 PV07_00305 PV07_00597 PV07_00597 PV07_04081 PV07_04081 PV07_00742 PV07_00742 PV07_04477 PV07_04477 PV07_06530 PV07_06530 PV07_01124 PV07_01124 PV07_06712 PV07_06712 PV07_06824 PV07_06824 PV07_06941 PV07_06941 PV07_01534 PV07_01534 PV07_07098 PV07_07098 PV07_07227 PV07_07227 PV07_07582 PV07_07582 PV07_02199 PV07_02199 PV07_07793 PV07_07793 PV07_01440 PV07_01440 COQ7 COQ7 PV07_01617 PV07_01617 PV07_08190 PV07_08190 PV07_01783 PV07_01783 PV07_04781 PV07_04781 PV07_04786 PV07_04786 PV07_02171 PV07_02171 PV07_05009 PV07_05009 PV07_05202 PV07_05202 PV07_05509 PV07_05509 PV07_05606 PV07_05606 PV07_05840 PV07_05840 PV07_06231 PV07_06231 PV07_03926 PV07_03926 PV07_00445 PV07_00445 PV07_00738 PV07_00738 PV07_00851 PV07_00851 PV07_00879 PV07_00879 PV07_00925 PV07_00925 PV07_01077 PV07_01077 PV07_01125 PV07_01125 PV07_01826 PV07_01826 PV07_01983 PV07_01983 PV07_02049 PV07_02049 PV07_02146 PV07_02146 PV07_02369 PV07_02369 PV07_03162 PV07_03162 PV07_03025 PV07_03025 PV07_06335 PV07_06335 PV07_06077 PV07_06077 PV07_05210 PV07_05210 PV07_07760 PV07_07760 PV07_07133 PV07_07133 PV07_09583 PV07_09583 PV07_09545 PV07_09545 PV07_09481 PV07_09481 PV07_09287 PV07_09287 PV07_09980 PV07_09980 PV07_11891 PV07_11891 PV07_11685 PV07_11685 PV07_11592 PV07_11592 COQ6 COQ6 PV07_12214 PV07_12214 PV07_12093 PV07_12093 PV07_01846 PV07_01846 cprA-2 cprA-2 PV07_00998 PV07_00998 PV07_00485 PV07_00485 PV07_00307 PV07_00307 PV07_00198 PV07_00198 PV07_04424 PV07_04424 PV07_04210 PV07_04210 PV07_04200 PV07_04200 PV07_03161 PV07_03161 PV07_03086 PV07_03086 PV07_02998 PV07_02998 PV07_02978 PV07_02978 PV07_06410 PV07_06410 PV07_06284 PV07_06284 cprA cprA PV07_05608 PV07_05608 PV07_05520 PV07_05520 PV07_08269 PV07_08269 PV07_07808 PV07_07808 PV07_07489 PV07_07489 PV07_07441 PV07_07441 PV07_07205 PV07_07205 PV07_06812 PV07_06812 PV07_06504 PV07_06504 PV07_06455 PV07_06455 PV07_09530 PV07_09530 PV07_09495 PV07_09495 hxB hxB PV07_09378 PV07_09378 COQ5 COQ5 PV07_08538 PV07_08538 PV07_08472 PV07_08472 PV07_09678 PV07_09678 PV07_11689 PV07_11689 PV07_11149 PV07_11149 PV07_12187 PV07_12187 PV07_12179 PV07_12179
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PV07_01176Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (719 aa)
PV07_033404-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (461 aa)
PV07_03533Uncharacterized protein. (216 aa)
PV07_03571Uncharacterized protein; Belongs to the GST superfamily. (859 aa)
PV07_03989Uncharacterized protein. (614 aa)
PV07_04127NmrA domain-containing protein. (327 aa)
PV07_00591OHCU_decarbox domain-containing protein. (177 aa)
PV07_00933Uncharacterized protein. (816 aa)
PV07_01839Uncharacterized protein. (197 aa)
PV07_02327Uncharacterized protein. (333 aa)
PV07_12474Uncharacterized protein; Belongs to the GST superfamily. (320 aa)
PV07_12328Uncharacterized protein. (705 aa)
PV07_11039Flavin_Reduct domain-containing protein. (336 aa)
PV07_11123Hsp90-like protein. (702 aa)
PV07_11243Mitochondrial thiamine pyrophosphate carrier 1, variant; Belongs to the mitochondrial carrier (TC 2.A.29) family. (330 aa)
PV07_11465ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (349 aa)
PV07_11681Uncharacterized protein; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (407 aa)
PV07_11761VOC domain-containing protein. (759 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (324 aa)
PV07_12056Uncharacterized protein. (359 aa)
PV07_10015Carrier domain-containing protein. (2081 aa)
PV07_10059Uncharacterized protein. (409 aa)
PV07_09938Uncharacterized protein. (138 aa)
PV07_10829Pantothenate kinase. (443 aa)
PV07_10139Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (136 aa)
PV07_10172FAD-binding FR-type domain-containing protein. (671 aa)
PV07_10486Uncharacterized protein. (2293 aa)
PV07_10631CoA carboxyltransferase C-terminal domain-containing protein. (836 aa)
PV07_08995Uncharacterized protein. (381 aa)
PV07_08442FAD_binding_3 domain-containing protein. (458 aa)
PV07_09192Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (367 aa)
PV07_09284Uncharacterized protein. (797 aa)
PV07_08871Macro domain-containing protein. (263 aa)
PV07_08939Uncharacterized protein. (677 aa)
PV07_06552Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (529 aa)
PV07_09435Uncharacterized protein; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (278 aa)
PV07_07102Uncharacterized protein; Belongs to the 5'-nucleotidase family. (631 aa)
PV07_06588Uncharacterized protein. (462 aa)
PV07_07286Methyltransf_25 domain-containing protein. (295 aa)
PV07_07136FSH1 domain-containing protein. (291 aa)
PV07_07278FAD-binding FR-type domain-containing protein. (756 aa)
PV07_07314Uncharacterized protein. (724 aa)
PV07_07323Uncharacterized protein. (572 aa)
PV07_07350NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (266 aa)
PV07_07519MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (502 aa)
PV07_08366FSH1 domain-containing protein. (251 aa)
PV07_04809Uncharacterized protein; Belongs to the GST superfamily. (277 aa)
PV07_04877Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (304 aa)
PV07_12338Uncharacterized protein. (1765 aa)
PV07_05977Uncharacterized protein. (87 aa)
PV07_06014Fungal_trans domain-containing protein. (675 aa)
PV07_10973Uncharacterized protein. (358 aa)
PV07_05208BTB domain-containing protein. (288 aa)
PV07_05308Uncharacterized protein. (2176 aa)
PV07_06309Uncharacterized protein; Belongs to the GST superfamily. (250 aa)
PV07_05519Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (747 aa)
PV07_05544Methylenetetrahydrofolate reductase. (803 aa)
PV07_05690DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (471 aa)
PV07_11532Fungal_trans domain-containing protein. (1037 aa)
PV07_05786Flavokinase domain-containing protein. (226 aa)
PV07_02788Molybdenum cofactor biosynthesis protein A. (928 aa)
PV07_05955Uncharacterized protein. (282 aa)
PV07_05969FAD_binding_3 domain-containing protein. (617 aa)
PV07_11883FAD_binding_3 domain-containing protein. (517 aa)
PV07_03083Uncharacterized protein. (319 aa)
PV07_06164Uncharacterized protein. (350 aa)
PV07_03405NmrA domain-containing protein. (330 aa)
PV07_03457Mur_ligase_M domain-containing protein. (526 aa)
PV07_10258L-serine ammonia-lyase. (727 aa)
PV07_10448Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (297 aa)
PV07_02977Carrier domain-containing protein. (2793 aa)
PV07_04291Biotin-[acetyl-CoA-carboxylase] ligase. (684 aa)
PV07_04549Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (490 aa)
PV07_04583NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450. (717 aa)
PV07_08938Uncharacterized protein. (581 aa)
PV07_00290Uncharacterized protein. (513 aa)
PV07_08984Uncharacterized protein. (243 aa)
PV07_00305MoCF_biosynth domain-containing protein. (336 aa)
PV07_00597FAD_binding_3 domain-containing protein. (552 aa)
PV07_04081Fungal_trans domain-containing protein. (530 aa)
PV07_00742Fungal_trans domain-containing protein. (1287 aa)
PV07_04477Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (642 aa)
PV07_06530FAD_binding_3 domain-containing protein. (575 aa)
PV07_01124PAPS_reduct domain-containing protein. (361 aa)
PV07_06712Uncharacterized protein. (294 aa)
PV07_06824Uncharacterized protein. (177 aa)
PV07_06941Uncharacterized protein. (333 aa)
PV07_01534Methyltransf_25 domain-containing protein. (281 aa)
PV07_07098FAD_binding_3 domain-containing protein. (439 aa)
PV07_07227FAD_binding_3 domain-containing protein. (607 aa)
PV07_07582Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
PV07_02199Fungal_trans domain-containing protein. (708 aa)
PV07_07793Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (354 aa)
PV07_01440Uncharacterized protein. (184 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (208 aa)
PV07_01617FAD_binding_3 domain-containing protein. (438 aa)
PV07_08190Uncharacterized protein. (1055 aa)
PV07_01783Uncharacterized protein. (336 aa)
PV07_04781Zn(2)-C6 fungal-type domain-containing protein. (774 aa)
PV07_04786FAD_binding_3 domain-containing protein. (676 aa)
PV07_02171MINDY_DUB domain-containing protein. (993 aa)
PV07_05009Uncharacterized protein; Belongs to the GST superfamily. (323 aa)
PV07_05202Uncharacterized protein. (173 aa)
PV07_05509GTP cyclohydrolase I. (355 aa)
PV07_05606Uncharacterized protein. (629 aa)
PV07_05840Metallophos domain-containing protein. (614 aa)
PV07_06231Fungal_trans domain-containing protein. (613 aa)
PV07_03926Zn(2)-C6 fungal-type domain-containing protein. (742 aa)
PV07_00445Nudix hydrolase domain-containing protein. (322 aa)
PV07_00738Uncharacterized protein. (312 aa)
PV07_00851Fungal_trans domain-containing protein. (686 aa)
PV07_008795-formyltetrahydrofolate cyclo-ligase. (253 aa)
PV07_00925FAD_binding_3 domain-containing protein. (416 aa)
PV07_01077Dephospho-CoA kinase. (283 aa)
PV07_01125Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (410 aa)
PV07_01826Uncharacterized protein. (360 aa)
PV07_01983Uncharacterized protein. (590 aa)
PV07_02049FAD_binding_3 domain-containing protein. (437 aa)
PV07_02146Nudix hydrolase domain-containing protein. (410 aa)
PV07_02369Uncharacterized protein. (384 aa)
PV07_03162Uncharacterized protein. (768 aa)
PV07_03025Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (392 aa)
PV07_06335Rhodanese domain-containing protein. (582 aa)
PV07_06077Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (533 aa)
PV07_05210Uncharacterized protein; Belongs to the cytochrome P450 family. (606 aa)
PV07_07760Uncharacterized protein. (491 aa)
PV07_07133MFS domain-containing protein. (587 aa)
PV07_09583Uncharacterized protein. (308 aa)
PV07_09545Uncharacterized protein. (247 aa)
PV07_09481MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
PV07_09287Uncharacterized protein. (540 aa)
PV07_09980Uncharacterized protein. (410 aa)
PV07_11891Uncharacterized protein. (153 aa)
PV07_11685Uncharacterized protein. (262 aa)
PV07_11592Uncharacterized protein. (255 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (536 aa)
PV07_12214Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (270 aa)
PV07_12093Uncharacterized protein. (1135 aa)
PV07_01846Amino_oxidase domain-containing protein. (557 aa)
cprA-2NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (703 aa)
PV07_00998Flavokinase domain-containing protein. (626 aa)
PV07_00485NmrA domain-containing protein. (322 aa)
PV07_00307Uncharacterized protein. (639 aa)
PV07_00198Fungal_trans domain-containing protein. (752 aa)
PV07_04424Uncharacterized protein. (611 aa)
PV07_04210Uncharacterized protein. (319 aa)
PV07_04200Carrier domain-containing protein. (2381 aa)
PV07_03161FAD_binding_3 domain-containing protein. (607 aa)
PV07_03086Nudix hydrolase domain-containing protein. (379 aa)
PV07_02998FSH1 domain-containing protein. (308 aa)
PV07_02978Condensation domain-containing protein. (166 aa)
PV07_06410FAD_binding_3 domain-containing protein. (1066 aa)
PV07_06284Nicotinate phosphoribosyltransferase. (450 aa)
cprANADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (967 aa)
PV07_05608Uncharacterized protein. (345 aa)
PV07_05520Nudix hydrolase domain-containing protein. (453 aa)
PV07_08269Uncharacterized protein. (340 aa)
PV07_07808FAD_binding_3 domain-containing protein. (664 aa)
PV07_07489Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (471 aa)
PV07_07441BTB domain-containing protein. (317 aa)
PV07_07205Uncharacterized protein. (614 aa)
PV07_06812Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)
PV07_06504FAD_binding_3 domain-containing protein. (465 aa)
PV07_06455Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (576 aa)
PV07_09530Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1186 aa)
PV07_09495Uncharacterized protein. (452 aa)
hxBMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (829 aa)
PV07_09378Uncharacterized protein. (559 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (302 aa)
PV07_08538Pyridoxal kinase. (369 aa)
PV07_08472Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (511 aa)
PV07_09678Uncharacterized protein; Belongs to the GST superfamily. (272 aa)
PV07_11689Uncharacterized protein. (143 aa)
PV07_11149Uncharacterized protein. (628 aa)
PV07_12187Uncharacterized protein; Belongs to the cytochrome P450 family. (558 aa)
PV07_12179Cysteine desulfurase, mitochondrial. (515 aa)
Your Current Organism:
Cladophialophora immunda
NCBI taxonomy Id: 569365
Other names: C. immunda, CBS 834.96, Cladophialophora sp. CBS 834.96, Cladophialophora sp. HB-2008
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