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fadB fadB gldA gldA AKL34004.1 AKL34004.1 accC accC accB accB AKL34155.1 AKL34155.1 gldA-2 gldA-2 yqhD_1 yqhD_1 AKL38772.1 AKL38772.1 scpB scpB AKL34501.1 AKL34501.1 AKL34556.1 AKL34556.1 AKL34558.1 AKL34558.1 AKL34605.1 AKL34605.1 pduW pduW AKL34660.1 AKL34660.1 AKL34661.1 AKL34661.1 AKL34665.1 AKL34665.1 pduE pduE pduD pduD pduC pduC AKL34776.1 AKL34776.1 fadJ fadJ accD accD pta pta ackA_2 ackA_2 ldh ldh AKL36331.1 AKL36331.1 lpdA lpdA iolS_3 iolS_3 pflD pflD AKL37067.1 AKL37067.1 mgsA mgsA pflB pflB AKL37303.1 AKL37303.1 sucD sucD sucC sucC accA accA AKL38133.1 AKL38133.1 lpdA-2 lpdA-2 adhE_8 adhE_8 AKL38385.1 AKL38385.1 mmsA mmsA mmsA-2 mmsA-2 acs acs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fadBMultifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (729 aa)
gldAGlycerol dehydrogenase; Forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AKL34004.14-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
accCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
accBacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa)
AKL34155.1Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
gldA-2Glycerol dehydrogenase; Forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
yqhD_1Aldehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AKL38772.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
scpBmethylmalonyl-CoA decarboxylase; Catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
AKL34501.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
AKL34556.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
AKL34558.1CoA-transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (533 aa)
AKL34605.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
pduWAcetate kinase; Enables the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AKL34660.1Propanediol utilization protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
AKL34661.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
AKL34665.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (210 aa)
pduEPropanediol dehydratase; With pduCD catalyzes the formation of propionaldehyde from 1,2-propanediol; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
pduDPropanediol dehydratase; With PduCE catalyzes the formation of propionaldehyde from 1,2-propanediol; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
pduCPropanediol dehydratase; With pduED catalyzes the formation of propionaldehyde from 1,2-propanediol; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
AKL34776.11,2-propanediol oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
fadJMultifunctional fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
ackA_2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (314 aa)
AKL36331.12,3-dehydroadipyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
lpdAE3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
iolS_3Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
pflDFormate acetyltransferase; Involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (765 aa)
AKL37067.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (866 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (152 aa)
pflBPyruvate formate-lyase; Formate acetyltransferase; catalyzes the formation of formate and acetyl-CoA from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
AKL37303.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (810 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
AKL38133.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (839 aa)
lpdA-2E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
adhE_8Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AKL38385.1Phosphate propanoyltransferase; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (206 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
mmsA-2Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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