(6 nodes) MCM domain network (Trichomonas vaginalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TVAG_111580	DNA helicase; Belongs to the MCM family. (799 aa)
	TVAG_122470	DNA helicase; Belongs to the MCM family. (842 aa)
	TVAG_484360	DNA helicase; Belongs to the MCM family. (698 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (457 aa)
	TVAG_198280	DNA helicase; Belongs to the MCM family. (754 aa)
	TVAG_250220	DNA helicase; Belongs to the MCM family. (752 aa)

Your Current Organism:

Trichomonas vaginalis

NCBI taxonomy Id: 5722
Other names: T. vaginalis, Tritrichomonas vaginalis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	TVAG_111580	A2DIB5	A2F017	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_122470	A2DIB5	A2DN04	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_198280	A2DIB5	A2DDL4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_250220	A2DIB5	A2DCM5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_484360	A2DIB5	A2FUI9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
TVAG_111580	MCM7	A2F017	A2DIB5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
TVAG_111580	TVAG_122470	A2F017	A2DN04	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_111580	TVAG_198280	A2F017	A2DDL4	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_111580	TVAG_250220	A2F017	A2DCM5	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_111580	TVAG_484360	A2F017	A2FUI9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_122470	MCM7	A2DN04	A2DIB5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
TVAG_122470	TVAG_111580	A2DN04	A2F017	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_122470	TVAG_198280	A2DN04	A2DDL4	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_122470	TVAG_250220	A2DN04	A2DCM5	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_122470	TVAG_484360	A2DN04	A2FUI9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_198280	MCM7	A2DDL4	A2DIB5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
TVAG_198280	TVAG_111580	A2DDL4	A2F017	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_198280	TVAG_122470	A2DDL4	A2DN04	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_198280	TVAG_250220	A2DDL4	A2DCM5	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
TVAG_198280	TVAG_484360	A2DDL4	A2FUI9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999