(59 nodes) Nucleic acid-binding, OB-fold network (Trichomonas vaginalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TVAG_379780	Eukaryotic translation initiation factor 2 alpha subunit family protein. (306 aa)
	TVAG_128250	Proteasome endopeptidase complex, putative; Belongs to the AAA ATPase family. (423 aa)
	TVAG_060460	OB-fold nucleic acid binding domain containing protein. (568 aa)
	TVAG_198280	DNA helicase; Belongs to the MCM family. (754 aa)
	TVAG_250220	DNA helicase; Belongs to the MCM family. (752 aa)
	TVAG_035330	Proteasome endopeptidase complex, putative; Belongs to the AAA ATPase family. (422 aa)
	TVAG_186530	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (146 aa)
	TVAG_071920	40S ribosomal protein S23, putative; Belongs to the universal ribosomal protein uS12 family. (144 aa)
	TVAG_433230	AAA domain-containing protein; Belongs to the AAA ATPase family. (382 aa)
	TVAG_228330	tRNA binding domain containing protein. (210 aa)
	TVAG_246740	Exonuclease, putative. (253 aa)
	TVAG_294830	Uncharacterized protein. (590 aa)
	TVAG_267950	AA_TRNA_LIGASE_II domain-containing protein. (537 aa)
	TVAG_122470	DNA helicase; Belongs to the MCM family. (842 aa)
	TVAG_050990	Uncharacterized protein. (68 aa)
	TVAG_292010	S1 RNA binding domain containing protein. (1601 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (457 aa)
	TVAG_113950	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family. (155 aa)
	TVAG_110240	Uncharacterized protein. (146 aa)
	TVAG_162990	DNA ligase. (679 aa)
	TVAG_283020	Eukaryotic translation initiation factor 5A. (167 aa)
	TVAG_487720	Uncharacterized protein. (107 aa)
	TVAG_336920	tRNA binding domain containing protein. (171 aa)
	TVAG_473090	BRCA2 repeat family protein. (1664 aa)
	TVAG_299100	Helicase, putative. (1006 aa)
	TVAG_494940	Uncharacterized protein. (218 aa)
	TVAG_111540	RNA polymerase Rpb7, N-terminal domain containing protein. (182 aa)
	TVAG_111580	DNA helicase; Belongs to the MCM family. (799 aa)
	TVAG_025680	Uncharacterized protein. (115 aa)
	TVAG_027240	Eukaryotic initiation factor 1A family protein. (139 aa)
	TVAG_328570	tRNA binding domain containing protein. (383 aa)
	TVAG_152430	Lysine--tRNA ligase. (605 aa)
	TVAG_115420	Proteasome endopeptidase complex, putative; Belongs to the AAA ATPase family. (391 aa)
	TVAG_433860	Replication protein A subunit. (659 aa)
	TVAG_477530	AAA domain-containing protein; Belongs to the AAA ATPase family. (388 aa)
	TVAG_018260	OB-fold nucleic acid binding domain containing protein. (193 aa)
	TVAG_000070	tRNA binding domain containing protein. (206 aa)
	TVAG_443060	Uncharacterized protein. (68 aa)
	TVAG_243750	S1 RNA binding domain containing protein. (125 aa)
	TVAG_156640	Asparaginyl-tRNA synthetase family protein. (624 aa)
	TVAG_484360	DNA helicase; Belongs to the MCM family. (698 aa)
	TVAG_311220	RNB-like protein; Belongs to the RNR ribonuclease family. (863 aa)
	TVAG_415700	S1 motif domain-containing protein. (174 aa)
	TVAG_099560	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family. (155 aa)
	TVAG_121320	Uncharacterized protein. (139 aa)
	TVAG_200150	RNA polymerase Rpb7, N-terminal domain containing protein. (206 aa)
	TVAG_043270	Multisynthetase complex auxiliary component p43, putative. (113 aa)
	TVAG_226230	Uncharacterized protein. (590 aa)
	TVAG_135700	Proteasome endopeptidase complex, putative; Belongs to the AAA ATPase family. (388 aa)
	TVAG_361780	Eukaryotic translation initiation factor 5A. (167 aa)
	TVAG_097340	Uncharacterized protein. (241 aa)
	TVAG_583010	Uncharacterized protein. (186 aa)
	TVAG_569160	Uncharacterized protein. (175 aa)
	TVAG_187730	mRNA capping enzyme, C-terminal domain containing protein. (561 aa)
	TVAG_380110	S1 domain-containing protein. (178 aa)
	TVAG_212480	RuvB-like helicase; Belongs to the RuvB family. (505 aa)
	TVAG_074870	Proteasome, putative; Belongs to the AAA ATPase family. (468 aa)
	TVAG_005910	Ribosomal protein L8, putative. (251 aa)
	TVAG_005990	Uncharacterized protein. (242 aa)

Your Current Organism:

Trichomonas vaginalis

NCBI taxonomy Id: 5722
Other names: T. vaginalis, Tritrichomonas vaginalis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	TVAG_005910	A2DIB5	A2E6Z8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Ribosomal protein L8, putative.	0.436
MCM7	TVAG_005990	A2DIB5	A2E706	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.846
MCM7	TVAG_060460	A2DIB5	A2ECH5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	OB-fold nucleic acid binding domain containing protein.	0.905
MCM7	TVAG_097340	A2DIB5	A2GK52	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.846
MCM7	TVAG_111580	A2DIB5	A2F017	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_122470	A2DIB5	A2DN04	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_162990	A2DIB5	A2DFX6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.965
MCM7	TVAG_198280	A2DIB5	A2DDL4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_212480	A2DIB5	A2E2N8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	RuvB-like helicase; Belongs to the RuvB family.	0.549
MCM7	TVAG_226230	A2DIB5	A2G5D0	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.905
MCM7	TVAG_250220	A2DIB5	A2DCM5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_294830	A2DIB5	A2DL41	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.905
MCM7	TVAG_433860	A2DIB5	A2F7T1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit.	0.905
MCM7	TVAG_473090	A2DIB5	A2ERV5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	BRCA2 repeat family protein.	0.437
MCM7	TVAG_484360	A2DIB5	A2FUI9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	TVAG_569160	A2DIB5	A2HWJ8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.846
MCM7	TVAG_583010	A2DIB5	A2HNT8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.846
TVAG_000070	TVAG_005910	A2FFW8	A2E6Z8	tRNA binding domain containing protein.	Ribosomal protein L8, putative.	0.675
TVAG_000070	TVAG_027240	A2FFW8	A2F1G9	tRNA binding domain containing protein.	Eukaryotic initiation factor 1A family protein.	0.485
TVAG_000070	TVAG_043270	A2FFW8	A2G3P9	tRNA binding domain containing protein.	Multisynthetase complex auxiliary component p43, putative.	0.999