(14 nodes) Assembly of the ORC complex at the origin of replication network (Trichomonas vaginalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TVAG_185790	Uncharacterized protein. (323 aa)
	TVAG_376490	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (593 aa)
	TVAG_321390	Histone H2B, testis, putative; Belongs to the histone H2B family. (66 aa)
	TVAG_490350	Uncharacterized protein. (882 aa)
	TVAG_244490	Uncharacterized protein. (868 aa)
	TVAG_340580	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (605 aa)
	TVAG_364430	Uncharacterized protein. (825 aa)
	TVAG_467730	Uncharacterized protein. (343 aa)
	TVAG_188290	Importin N-terminal domain-containing protein. (879 aa)
	TVAG_067060	Importin N-terminal domain-containing protein. (890 aa)
	TVAG_026390	Histone H2B; Belongs to the histone H2B family. (129 aa)
	TVAG_365960	Uncharacterized protein. (375 aa)
	TVAG_163310	Uncharacterized protein. (816 aa)
	TVAG_248990	Uncharacterized protein. (852 aa)

Your Current Organism:

Trichomonas vaginalis

NCBI taxonomy Id: 5722
Other names: T. vaginalis, Tritrichomonas vaginalis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TVAG_026390	TVAG_185790	A2DJ26	A2D8M3	Histone H2B; Belongs to the histone H2B family.	Uncharacterized protein.	0.660
TVAG_026390	TVAG_340580	A2DJ26	A2EKH1	Histone H2B; Belongs to the histone H2B family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.879
TVAG_026390	TVAG_365960	A2DJ26	A2DHP0	Histone H2B; Belongs to the histone H2B family.	Uncharacterized protein.	0.407
TVAG_026390	TVAG_376490	A2DJ26	A2FU77	Histone H2B; Belongs to the histone H2B family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.879
TVAG_026390	TVAG_467730	A2DJ26	A2E0L3	Histone H2B; Belongs to the histone H2B family.	Uncharacterized protein.	0.879
TVAG_067060	TVAG_340580	A2DSC2	A2EKH1	Importin N-terminal domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.629
TVAG_067060	TVAG_365960	A2DSC2	A2DHP0	Importin N-terminal domain-containing protein.	Uncharacterized protein.	0.618
TVAG_067060	TVAG_376490	A2DSC2	A2FU77	Importin N-terminal domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.629
TVAG_067060	TVAG_467730	A2DSC2	A2E0L3	Importin N-terminal domain-containing protein.	Uncharacterized protein.	0.629
TVAG_163310	TVAG_340580	A2DG08	A2EKH1	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.629
TVAG_163310	TVAG_365960	A2DG08	A2DHP0	Uncharacterized protein.	Uncharacterized protein.	0.618
TVAG_163310	TVAG_376490	A2DG08	A2FU77	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.629
TVAG_163310	TVAG_467730	A2DG08	A2E0L3	Uncharacterized protein.	Uncharacterized protein.	0.629
TVAG_185790	TVAG_026390	A2D8M3	A2DJ26	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.660
TVAG_185790	TVAG_321390	A2D8M3	A2FK62	Uncharacterized protein.	Histone H2B, testis, putative; Belongs to the histone H2B family.	0.660
TVAG_185790	TVAG_340580	A2D8M3	A2EKH1	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.994
TVAG_185790	TVAG_365960	A2D8M3	A2DHP0	Uncharacterized protein.	Uncharacterized protein.	0.999
TVAG_185790	TVAG_376490	A2D8M3	A2FU77	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.994
TVAG_185790	TVAG_467730	A2D8M3	A2E0L3	Uncharacterized protein.	Uncharacterized protein.	0.988
TVAG_188290	TVAG_340580	A2DV51	A2EKH1	Importin N-terminal domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.629