node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADG91916.1 | ADG91917.1 | Arnit_0250 | Arnit_0251 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.984 |
ADG91916.1 | ADG91925.1 | Arnit_0250 | Arnit_0259 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |
ADG91916.1 | ADG93066.1 | Arnit_0250 | Arnit_1408 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | KEGG: cth:Cthe_2304 hypothetical protein; SPTR: A3DHS7 Putative uncharacterized protein; PFAM: Methylenetetrahydrofolate reductase. | 0.818 |
ADG91916.1 | ADG93116.1 | Arnit_0250 | Arnit_1459 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); InterPro IPR003726; KEGG: bsu:BSU02410 homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: C2A2N3 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase. | 0.925 |
ADG91916.1 | ADG94299.1 | Arnit_0250 | Arnit_2651 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR015421:IPR015424:IPR004839; KEGG: abu:Abu_0316 aminotransferase/L-cysteine desulfhydrase; PFAM: aminotransferase class I and II; SPTR: A8ERL7 Aminotransferase/L-cysteine desulfhydrase; PFAM: Aminotransferase class I and II. | 0.949 |
ADG91916.1 | ADG94732.1 | Arnit_0250 | Arnit_3085 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR015424:IPR015421:IPR 015422; KEGG: abu:Abu_2169 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: A8EWR0 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.941 |
ADG91916.1 | metAA | Arnit_0250 | Arnit_0815 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.689 |
ADG91916.1 | metE | Arnit_0250 | Arnit_0516 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.968 |
ADG91916.1 | metXA | Arnit_0250 | Arnit_1471 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.528 |
ADG91917.1 | ADG91916.1 | Arnit_0251 | Arnit_0250 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.984 |
ADG91917.1 | ADG91925.1 | Arnit_0251 | Arnit_0259 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |
ADG91917.1 | ADG93066.1 | Arnit_0251 | Arnit_1408 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | KEGG: cth:Cthe_2304 hypothetical protein; SPTR: A3DHS7 Putative uncharacterized protein; PFAM: Methylenetetrahydrofolate reductase. | 0.818 |
ADG91917.1 | ADG93116.1 | Arnit_0251 | Arnit_1459 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); InterPro IPR003726; KEGG: bsu:BSU02410 homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: C2A2N3 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase. | 0.922 |
ADG91917.1 | ADG94299.1 | Arnit_0251 | Arnit_2651 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR015421:IPR015424:IPR004839; KEGG: abu:Abu_0316 aminotransferase/L-cysteine desulfhydrase; PFAM: aminotransferase class I and II; SPTR: A8ERL7 Aminotransferase/L-cysteine desulfhydrase; PFAM: Aminotransferase class I and II. | 0.932 |
ADG91917.1 | ADG94732.1 | Arnit_0251 | Arnit_3085 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR015424:IPR015421:IPR 015422; KEGG: abu:Abu_2169 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: A8EWR0 O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.980 |
ADG91917.1 | metAA | Arnit_0251 | Arnit_0815 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.962 |
ADG91917.1 | metE | Arnit_0251 | Arnit_0516 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.964 |
ADG91917.1 | metXA | Arnit_0251 | Arnit_1471 | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.943 |
ADG91925.1 | ADG91916.1 | Arnit_0259 | Arnit_0250 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterProIPR015424:IPR000209:IPR000277:IPR015421:IPR 015422; KEGG: abu:Abu_1723 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: A8EVJ7 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.980 |
ADG91925.1 | ADG91917.1 | Arnit_0259 | Arnit_0251 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR015424:IPR015421:IPR000277; KEGG: abu:Abu_1724 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: A8EVJ8 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.980 |