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hisF hisF aroK aroK ADB57129.1 ADB57129.1 purS purS purL purL pyrE pyrE ADB57257.1 ADB57257.1 dapB dapB trpA trpA trpB trpB ADB57278.1 ADB57278.1 ADB57279.1 ADB57279.1 trpF trpF ADB57281.1 ADB57281.1 trpE trpE trpD trpD trpC trpC argH argH thyX thyX dapF dapF argC argC tmk tmk purM purM ADB57459.1 ADB57459.1 hisB hisB hisA hisA pyrD pyrD aroC aroC purA purA ndk ndk hisC hisC carB carB carA carA purC purC purE purE glyA glyA pyrF pyrF ADB57836.1 ADB57836.1 purQ purQ hisH hisH surE surE aroE aroE aroA-2 aroA-2 lysA lysA guaAA guaAA pyrH pyrH ADB58034.1 ADB58034.1 aroB aroB purF purF hisD hisD guaAB guaAB hisG hisG ADB58107.1 ADB58107.1 dapA dapA purD purD pyrI pyrI pyrB pyrB ADB58179.1 ADB58179.1 hisC-2 hisC-2 argB argB argD argD ADB58343.1 ADB58343.1 hisE hisE ADB58512.1 ADB58512.1 ADB58592.1 ADB58592.1 ADB58604.1 ADB58604.1 trpB-2 trpB-2 argG argG argJ argJ ADB58678.1 ADB58678.1 aroD aroD ADB58893.1 ADB58893.1
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hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa)
aroKShikimate kinase; KEGG: bab:bbp182 homoserine kinase; TIGRFAM: shikimate kinase; PFAM: GHMP kinase. (284 aa)
ADB57129.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (181 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (761 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (171 aa)
ADB57257.1PFAM: phosphoribosyltransferase; KEGG: URA5; One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; K00762. (196 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa)
ADB57278.1KEGG: wsu:WS1407 hypothetical protein. (124 aa)
ADB57279.1KEGG: wsu:WS1407 hypothetical protein. (118 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gsu:GSU2378 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa)
ADB57281.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: efe:EFER_3333 aminodeoxychorismate synthase, subunit II. (190 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (434 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: sat:SYN_02591 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (227 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: hch:HCH_00294 argininosuccinate lyase. (470 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (263 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (279 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (332 aa)
tmkKEGG: dps:DP2809 thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase; deoxynucleoside kinase. (199 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: Os03g0831500; hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase. (330 aa)
ADB57459.1KEGG: gbm:Gbem_3637 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (305 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: xfm:Xfasm12_1417 histidinol-phosphatase. (182 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: gur:Gura_4054 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. (232 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (294 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (341 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (149 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: hypothetical protein; K00817 histidinol- phosphate aminotransferase. (348 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; phosphoribosylglycinamide synthetase; RimK domain protein ATP-grasp; MGS domain protein; ATP- grasp domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: gur:Gura_1864 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1091 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (358 aa)
purCKEGG: bba:Bd3007 phosphoribosylaminoimidazolesuccinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (335 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
ADB57836.1PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: tgr:Tgr7_1136 oxidoreductase FAD/NAD(P)- binding domain protein. (226 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (273 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
guaAAGMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (184 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (226 aa)
ADB58034.1KEGG: dvm:DvMF_1751 fructose-bisphosphate aldolase; TIGRFAM: predicted phospho-2-dehydro-3- deoxyheptonate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2- dehydro-3-deoxyheptonate aldolase. (252 aa)
aroB3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (334 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (461 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (411 aa)
guaABGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (304 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (280 aa)
ADB58107.1PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: gbm:Gbem_3178 peptidase M20. (328 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
purDKEGG: sfu:Sfum_2759 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (472 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; KEGG: cvi:CV_0369 aspartate carbamoyltransferase catalytic subunit. (299 aa)
ADB58179.1PFAM: aminotransferase class I and II; KEGG: dal:Dalk_0414 aminotransferase class I and II. (387 aa)
hisC-2TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase. (365 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (289 aa)
argDKEGG: sfu:Sfum_0063 acetylornithine and succinylornithine aminotransferases; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (381 aa)
ADB58343.1TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: nam:NAMH_1763 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)
hisETIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gbm:Gbem_3699 phosphoribosyl-ATP diphosphatase. (93 aa)
ADB58512.1KEGG: pca:Pcar_2283 3-phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. (390 aa)
ADB58592.1PFAM: prephenate dehydratase; Prephenate dehydrogenase; amino acid-binding ACT domain protein; Chorismate mutase; KEGG: mms:mma_2673 bifunctional chorismate mutase / prephenate dehydratase. (619 aa)
ADB58604.1TIGRFAM: acetylornithine deacetylase or succinyl- diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: sat:SYN_02795 succinyl-diaminopimelate desuccinylase. (401 aa)
trpB-2Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa)
argGArgininosuccinate synthase; KEGG: Os12g0235800; hypothetical protein; K01940 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; ExsB family protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (381 aa)
ADB58678.1TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: Dsim_r; rudimentary. (387 aa)
aroD3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (201 aa)
ADB58893.1PFAM: protein of unknown function UPF0066; KEGG: avn:Avin_38460 hypothetical protein. (278 aa)
Your Current Organism:
Archaeoglobus profundus
NCBI taxonomy Id: 572546
Other names: A. profundus DSM 5631, Archaeoglobus profundus DSM 5631, Archaeoglobus profundus str. DSM 5631, Archaeoglobus profundus strain DSM 5631
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