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purS purS purL purL pyrE pyrE ADB57257.1 ADB57257.1 ADB57295.1 ADB57295.1 purM purM pyrD pyrD purA purA ADB57724.1 ADB57724.1 carB carB carA carA purC purC purE purE ADB57743.1 ADB57743.1 pyrF pyrF prs prs ADB57836.1 ADB57836.1 purQ purQ guaAA guaAA purF purF ADB58069.1 ADB58069.1 guaAB guaAB purD purD pyrB pyrB purP purP ADB58283.1 ADB58283.1 ribK ribK ADB58343.1 ADB58343.1 adk adk ADB58593.1 ADB58593.1 ADB58663.1 ADB58663.1 ADB58678.1 ADB58678.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (761 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (171 aa)
ADB57257.1PFAM: phosphoribosyltransferase; KEGG: URA5; One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; K00762. (196 aa)
ADB57295.1PFAM: MGS domain protein; KEGG: hypothetical protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase. (155 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: Os03g0831500; hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase. (330 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (294 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (341 aa)
ADB57724.1PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; KEGG: mxa:MXAN_6690 circadian phase modifier CpmA- like protein. (234 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; phosphoribosylglycinamide synthetase; RimK domain protein ATP-grasp; MGS domain protein; ATP- grasp domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: gur:Gura_1864 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1091 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (358 aa)
purCKEGG: bba:Bd3007 phosphoribosylaminoimidazolesuccinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (335 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
ADB57743.1Hypothetical protein; KEGG: bab:bbp097 amidotransferase HisH. (180 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (276 aa)
ADB57836.1PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: tgr:Tgr7_1136 oxidoreductase FAD/NAD(P)- binding domain protein. (226 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (273 aa)
guaAAGMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (184 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (461 aa)
ADB58069.1PFAM: phosphoribosyltransferase; KEGG: mca:MCA2827 phosphoribosyl transferase domain- containing protein. (219 aa)
guaABGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (304 aa)
purDKEGG: sfu:Sfum_2759 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (472 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; KEGG: cvi:CV_0369 aspartate carbamoyltransferase catalytic subunit. (299 aa)
purPIMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (352 aa)
ADB58283.1PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP. (376 aa)
ribKTranscriptional regulator, MarR family; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (215 aa)
ADB58343.1TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: nam:NAMH_1763 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
ADB58593.1PFAM: phosphoribulokinase/uridine kinase; KEGG: PRK1; phosphoribulokinase; K00855 phosphoribulokinase. (318 aa)
ADB58663.1PFAM: phosphoribosyltransferase; KEGG: sat:SYN_03353 xanthine-guanine phosphoribosyltransferase. (195 aa)
ADB58678.1TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: Dsim_r; rudimentary. (387 aa)
Your Current Organism:
Archaeoglobus profundus
NCBI taxonomy Id: 572546
Other names: A. profundus DSM 5631, Archaeoglobus profundus DSM 5631, Archaeoglobus profundus str. DSM 5631, Archaeoglobus profundus strain DSM 5631
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