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| | ADB57093.1 | TIGRFAM: siroheme synthase; PFAM: TrkA-N domain protein; KEGG: aha:AHA_4121 siroheme synthase. (231 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | aroK | Shikimate kinase; KEGG: bab:bbp182 homoserine kinase; TIGRFAM: shikimate kinase; PFAM: GHMP kinase. (284 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (321 aa) |
| | ADB57120.1 | PFAM: Cobalamin-independent synthase MetE domain protein; Methionine synthase vitamin-B12 independent; KEGG: hypothetical protein; K00549 5- methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (315 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (761 aa) |
| | ADB57151.1 | PFAM: asparagine synthase; KEGG: asparagine synthetase B. (375 aa) |
| | ADB57180.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (290 aa) |
| | ADB57210.1 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: neu:NE0532 uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. (241 aa) |
| | ADB57216.1 | TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; Hydroxymethylglutaryl- coenzyme A synthase domain; KEGG: pfl:PFL_5954 hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family. (344 aa) |
| | ADB57217.1 | PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase. (384 aa) |
| | ADB57242.1 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: sfu:Sfum_3024 acetolactate synthase, large subunit, biosynthetic type. (552 aa) |
| | ADB57243.1 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: sfu:Sfum_3022 acetolactate synthase, small subunit. (162 aa) |
| | ADB57255.1 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_0234 radical SAM domain protein. (339 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (409 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gsu:GSU2378 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | ADB57281.1 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: efe:EFER_3333 aminodeoxychorismate synthase, subunit II. (190 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (434 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: sat:SYN_02591 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (227 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: hch:HCH_00294 argininosuccinate lyase. (470 aa) |
| | ADB57313.1 | Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: dol:Dole_1573 hydroxypyruvate reductase. (444 aa) |
| | ADB57318.1 | KEGG: aeh:Mlg_0262 isocitrate dehydrogenase, NADP- dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (409 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (667 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (279 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (219 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (332 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa) |
| | ADB57346.1 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: rlt:Rleg2_5063 homoserine dehydrogenase. (330 aa) |
| | ADB57348.1 | PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; KEGG: Phosphoglucomutase/phosphomannomutase, C- terminal domain containing protein; K01840 phosphomannomutase; Belongs to the phosphohexose mutase family. (451 aa) |
| | ADB57349.1 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (178 aa) |
| | ADB57361.1 | PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: rpt:Rpal_1693 magnesium chelatase ATPase subunit I. (476 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (246 aa) |
| | ADB57393.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (231 aa) |
| | ADB57396.1 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dol:Dole_1225 radical SAM domain-containing protein. (372 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: wbm:Wbm0684 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (405 aa) |
| | ADB57448.1 | KEGG: aha:AHA_1152 isocitrate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (327 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: Os03g0831500; hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase. (330 aa) |
| | ADB57459.1 | KEGG: gbm:Gbem_3637 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (305 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: xfm:Xfasm12_1417 histidinol-phosphatase. (182 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: gur:Gura_4054 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. (232 aa) |
| | ADB57510.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo- inositol-1-phosphate synthase GAPDH domain protein; KEGG: sfu:Sfum_1982 inositol-3-phosphate synthase. (394 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | ADB57541.1 | TIGRFAM: riboflavin synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase. (153 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (149 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (142 aa) |
| | ADB57594.1 | PFAM: aminotransferase class I and II; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: nis:NIS_0815 aspartate aminotransferase. (375 aa) |
| | ADB57597.1 | TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: sat:SYN_00159 fumarate hydratase. (272 aa) |
| | ADB57598.1 | KEGG: bph:Bphy_5632 tartrate/fumarate subfamily Fe- S type hydro-lyase beta subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (188 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (554 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (363 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (244 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gur:Gura_4245 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (436 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (292 aa) |
| | ADB57658.1 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dol:Dole_3062 uroporphyrin-III C- methyltransferase; Belongs to the precorrin methyltransferase family. (256 aa) |
| | ADB57687.1 | PFAM: Lactate/malate dehydrogenase; KEGG: afw:Anae109_2185 malate dehydrogenase, NAD- dependent; Belongs to the LDH/MDH superfamily. (294 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: hypothetical protein; K00817 histidinol- phosphate aminotransferase. (348 aa) |
| | ADB57721.1 | PFAM: Radical SAM domain protein; cobalamin B12- binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dal:Dalk_5142 radical SAM domain protein. (458 aa) |
| | purC | KEGG: bba:Bd3007 phosphoribosylaminoimidazolesuccinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (335 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa) |
| | ADB57755.1 | KEGG: sat:SYN_00123 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (525 aa) |
| | ADB57759.1 | PFAM: Nucleotidyl transferase; KEGG: ppd:Ppro_0028 nucleotidyl transferase. (330 aa) |
| | acsA-2 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (641 aa) |
| | ADB57772.1 | KEGG: aspartate kinase; K00928 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (462 aa) |
| | ADB57787.1 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dal:Dalk_3856 radical SAM domain protein. (375 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II; KEGG: ajs:Ajs_2165 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase. (340 aa) |
| | ADB57807.1 | Isopropylmalate/citramalate/homocitratesynthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: geo:Geob_1504 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (498 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (276 aa) |
| | ADB57824.1 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: sat:SYN_00693 pyruvate synthase gamma chain. (180 aa) |
| | ADB57825.1 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sat:SYN_00694 pyruvate synthase delta subunit. (84 aa) |
| | ADB57826.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: sat:SYN_00692 pyruvate synthase alpha chain. (371 aa) |
| | ADB57827.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: dol:Dole_1391 thiamine pyrophosphate binding domain-containing protein. (285 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa) |
| | ADB57877.1 | SPP-like hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (219 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (273 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa) |
| | ADB57931.1 | KEGG: rhi:NGR_c08720 phosphatidylserine decarboxylase; TIGRFAM: phosphatidylserine decarboxylase related protein; PFAM: phosphatidylserine decarboxylase-related. (188 aa) |
| | ADB57932.1 | TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: nis:NIS_1408 CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (198 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | ADB57938.1 | PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: VTE3; MPBQ/MSBQ methyltransferase. (205 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (282 aa) |
| | ADB58034.1 | KEGG: dvm:DvMF_1751 fructose-bisphosphate aldolase; TIGRFAM: predicted phospho-2-dehydro-3- deoxyheptonate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2- dehydro-3-deoxyheptonate aldolase. (252 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (334 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (159 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (461 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (411 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (292 aa) |
| | ADB58082.1 | KEGG: sun:SUN_0324 mannose-1-phosphate guanylyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. (444 aa) |
| | mat | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (399 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (280 aa) |
| | ADB58107.1 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: gbm:Gbem_3178 peptidase M20. (328 aa) |
| | ADB58116.1 | KEGG: sat:SYN_00157 pyruvate:ferredoxin oxidoreductase gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (188 aa) |
| | ADB58117.1 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sat:SYN_00694 pyruvate synthase delta subunit. (91 aa) |
| | ADB58118.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rfr:Rfer_2186 pyruvate flavodoxin/ferredoxin oxidoreductase-like. (380 aa) |
| | ADB58119.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rfr:Rfer_2185 thiamine pyrophosphate enzyme- like TPP-binding. (290 aa) |
| | ADB58129.1 | PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; von Willebrand factor type A; KEGG: ppd:Ppro_1261 magnesium chelatase. (635 aa) |
| | ADB58145.1 | AtoB5; KEGG: dat:HRM2_45290 AtoB5. (393 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | purD | KEGG: sfu:Sfum_2759 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (472 aa) |
| | ADB58179.1 | PFAM: aminotransferase class I and II; KEGG: dal:Dalk_0414 aminotransferase class I and II. (387 aa) |
| | ADB58180.1 | KEGG: psp:PSPPH_2057 methylcitrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase. (379 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (376 aa) |
| | ADB58249.1 | TIGRFAM: glucose-1-phosphate thymidyltransferase; PFAM: Nucleotidyl transferase; KEGG: ccv:CCV52592_0305 glucose-1-phosphate thymidylyltransferase. (351 aa) |
| | ADB58250.1 | PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; polysaccharide biosynthesis protein CapD; SMART: Hedgehog/intein hint domain protein; KEGG: mxa:MXAN_4613 dTDP-glucose 4,6-dehydratase. (837 aa) |
| | ADB58253.1 | TIGRFAM: dTDP-4-dehydrorhamnose reductase; PFAM: dTDP-4-dehydrorhamnose reductase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; NAD-dependent epimerase/dehydratase; KEGG: ade:Adeh_4291 dTDP-4-dehydrorhamnose reductase. (291 aa) |
| | ADB58254.1 | KEGG: sat:SYN_00576 dTDP-4-dehydrorhamnose 3,5- epimerase. (165 aa) |
| | ADB58267.1 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: gsu:GSU0859 UTP-glucose-1-phosphate uridylyltransferase. (280 aa) |
| | purP | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (352 aa) |
| | ADB58283.1 | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP. (376 aa) |
| | ADB58287.1 | PFAM: glucose-6-phosphate isomerase; KEGG: stm:STM2757 putative cytoplasmic protein. (238 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (267 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase. (365 aa) |
| | ADB58303.1 | TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; KEGG: glo:Glov_0397 prenyltransferase. (277 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (371 aa) |
| | sat | KEGG: tbd:Tbd_0874 sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (456 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (289 aa) |
| | argD | KEGG: sfu:Sfum_0063 acetylornithine and succinylornithine aminotransferases; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (381 aa) |
| | ADB58326.1 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (235 aa) |
| | ADB58328.1 | TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; KEGG: bpt:Bpet3342 3-hydroxy-3-methylglutaryl- coenzyme A reductase. (413 aa) |
| | apgM | Proposed homoserine kinase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (391 aa) |
| | ADB58343.1 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: nam:NAMH_1763 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa) |
| | hisE | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gbm:Gbem_3699 phosphoribosyl-ATP diphosphatase. (93 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (357 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (185 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (427 aa) |
| | ADB58481.1 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sat:SYN_02267 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (308 aa) |
| | ADB58482.1 | PFAM: aminotransferase class I and II; aminotransferase class V; KEGG: dal:Dalk_3407 aminotransferase class I and II. (372 aa) |
| | ADB58503.1 | TIGRFAM: phosphoenolpyruvate synthase; PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; PEP-utilising protein mobile region; PEP- utilizing protein; KEGG: phosphoenolpyruvate synthase; K01007 pyruvate,water dikinase. (749 aa) |
| | ADB58504.1 | PFAM: Polyprenyl synthetase; KEGG: cbg:CbuG_1627 farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (293 aa) |
| | ilvD | KEGG: gsu:GSU1912 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (547 aa) |
| | ADB58512.1 | KEGG: pca:Pcar_2283 3-phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD- superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. (390 aa) |
| | ADB58586.1 | PFAM: inositol monophosphatase; KEGG: dol:Dole_0004 inositol-phosphate phosphatase. (257 aa) |
| | ADB58592.1 | PFAM: prephenate dehydratase; Prephenate dehydrogenase; amino acid-binding ACT domain protein; Chorismate mutase; KEGG: mms:mma_2673 bifunctional chorismate mutase / prephenate dehydratase. (619 aa) |
| | trpB-2 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | ADB58608.1 | Dimethylallyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: gur:Gura_3743 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (327 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (359 aa) |
| | ADB58610.1 | Aspartate/glutamate/uridylate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (239 aa) |
| | argG | Argininosuccinate synthase; KEGG: Os12g0235800; hypothetical protein; K01940 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; ExsB family protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa) |
| | ribL | Cytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (155 aa) |
| | ADB58633.1 | PFAM: glycine hydroxymethyltransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: bpy:Bphyt_0271 glycine hydroxymethyltransferase. (403 aa) |
| | ADB58638.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (393 aa) |
| | ADB58639.1 | KEGG: mxa:MXAN_1192 alpha,alpha-trehalose-phosphate synthase/trehalose-phosphatase; TIGRFAM: alpha,alpha-trehalose-phosphate synthase [UDP-forming]; trehalose-phosphatase; HAD-superfamily hydrolase, subfamily IIB; PFAM: glycosyl transferase family 20; glycosyl transferase group 1; trehalose-phosphatase. (719 aa) |
| | ADB58641.1 | TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; KEGG: afw:Anae109_4203 UbiD family decarboxylase. (483 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (381 aa) |
| | rbcL | Ribulose bisphosphate carboxylase, type III; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (447 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (201 aa) |
| | apgM-2 | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (410 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | ADB58883.1 | Hypothetical protein. (95 aa) |
| | ADB58884.1 | Hypothetical protein; KEGG: rms:RMA_0177 succinate dehydrogenase hydrophobic membrane anchor protein. (106 aa) |
| | ADB58885.1 | KEGG: asa:ASA_1104 fumarate reductase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (221 aa) |
| | ADB58886.1 | TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: vsp:VS_0248 fumarate reductase flavoprotein subunit. (597 aa) |
