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| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa) |
| | ADK79219.1 | COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR001697:IPR015794:IPR018209; KEGG: pth:PTH_2214 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (588 aa) |
| | ADK79227.1 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220:IPR020625; KEGG: bcl:ABC3607 dihydrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase; SPTR: Dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (300 aa) |
| | ADK79270.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: pmo:Pmob_1727 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme. (486 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa) |
| | ADK79361.1 | COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR010169:IPR002933:IPR011650:IPR001261; KEGG: bid:Bind_1040 acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Acetylornithine deacetylase (ArgE); TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: acetylornithine deacetylase (ArgE). (399 aa) |
| | ADK79370.1 | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (550 aa) |
| | ADK79390.1 | Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176:IPR004839:IPR004838; KEGG: cce:Ccel_1965 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; PFAM: Aminotransferase class I and II. (393 aa) |
| | ADK79431.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR001086:IPR002912; KEGG: sfu:Sfum_3724 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: 3-deoxy-7-phosphoheptulonate synthase., Prephenate dehydratase; SPTR: Prephenate dehydratase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: Prephenate dehydratase; ACT domain; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptona [...] (629 aa) |
| | ADK79599.1 | COGs: COG1760 L-serine deaminase; InterPro IPR005131:IPR005130; KEGG: app:CAP2UW1_0154 serine dehydratase alpha chain; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: Serine dehydratase alpha chain; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (425 aa) |
| | ADK79600.1 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013:IPR010140; KEGG: tro:trd_A0397 histidinol-phosphatase; PFAM: PHP domain protein; SPTR: Putative histidinol-phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (283 aa) |
| | ADK79647.1 | Aminotransferase class-III; COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814; KEGG: hor:Hore_14780 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: Aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa) |
| | ADK79702.1 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR005946; KEGG: tde:TDE2723 phosphoribosylpyrophosphate synthetase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: Phosphoribosylpyrophosphate synthetase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (412 aa) |
| | ADK79708.1 | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814:IPR017871:IPR001917; KEGG: hvo:HVO_B0257 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: Aminotransferase class-III; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; 2,4-diaminobutyrate 4-transaminases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | ADK79716.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG1171 Threonine dehydratase; InterPro IPR001926; KEGG: gtn:GTNG_2276 threonine dehydratase-like protein; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine dehydratase-like protein; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: ectoine utilization protein EutB. (329 aa) |
| | ADK79719.1 | COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR018042:IPR001341; KEGG: amt:Amet_3407 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: Aspartokinase; TIGRFAM: aspartate kinase; manually curated; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase; Belongs to the aspartokinase family. (434 aa) |
| | ADK79752.1 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1156 aa) |
| | ADK79802.1 | GCN5-related N-acetyltransferase; InterPro IPR000182; KEGG: bla:BLA_1389 acetyltransferase, GNAT family; PFAM: GCN5-related N-acetyltransferase; SPTR: Acetyltransferase; PFAM: Acetyltransferase (GNAT) family. (143 aa) |
| | ADK79872.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: mta:Moth_2404 fructose-1,6-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (280 aa) |
| | ADK79906.1 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220; KEGG: dihydrodipicolinate synthetase; PFAM: dihydrodipicolinate synthetase; SPTR: Dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (310 aa) |
| | ADK79914.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: gym:GYMC10_3582 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Putative uncharacterized protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (319 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa) |
| | ADK79950.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: tle:Tlet_1711 ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (285 aa) |
| | ADK79954.1 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: rle:pRL120033 putative D-allulose-6-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Putative D-allulose-6-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (230 aa) |
| | ADK79965.1 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ADK80017.1 | COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR000634:IPR004450; KEGG: cbf:CLI_1715 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (496 aa) |
| | ADK80018.1 | Proposed homoserine kinase; COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR019304:IPR006124:IPR004456:IPR013371; KEGG: cth:Cthe_1292 phosphoglycerate mutase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Proposed homoserine kinase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, ar [...] (403 aa) |
| | ADK80042.1 | COGs: COG1748 Saccharopine dehydrogenase and related protein; InterPro IPR005097; KEGG: ttu:TERTU_1609 saccharopine dehydrogenase; PFAM: Saccharopine dehydrogenase; SPTR: Saccharopine dehydrogenase; PFAM: Saccharopine dehydrogenase. (393 aa) |
| | ADK80058.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tpd:Teth39_1970 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (317 aa) |
| | pgk | COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR015911:IPR001576; KEGG: kol:Kole_0995 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (419 aa) |
| | ADK80124.1 | Glyceraldehyde-3-phosphate dehydrogenase, type II; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000846:IPR020829:IPR006436:IPR020831; KEGG: kol:Kole_0996 glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; dihydrodipicolinate reductase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); SPTR: Glyceraldehyde-3-phosphate dehydrogenase, type II; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate de [...] (340 aa) |
| | ADK80128.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR006139; KEGG: sna:Snas_1558 phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (327 aa) |
| | ADK80149.1 | Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: gym:GYMC10_1404 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; PFAM: Aminotransferase class I and II. (392 aa) |
| | ADK80154.1 | Dipeptidase; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR002933:IPR010964; KEGG: hor:Hore_08190 Xaa-His dipeptidase; PFAM: peptidase M20; SPTR: Xaa-His dipeptidase; TIGRFAM: dipeptidase; PFAM: Peptidase family M20/M25/M40; TIGRFAM: dipeptidase, putative. (478 aa) |
| | ADK80160.1 | Transketolase central region; COGs: COG3958 Transketolase C-terminal subunit; InterPro IPR005475:IPR005476; KEGG: kpu:KP1_1545 putative transketolase C-terminal subunit; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Putative transketolase C-terminal subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (320 aa) |
| | ADK80161.1 | Transketolase domain protein; COGs: COG3959 Transketolase N-terminal subunit; InterPro IPR005474; KEGG: asu:Asuc_0171 transketolase domain-containing protein; PFAM: Transketolase domain protein; SPTR: Transketolase domain protein; PFAM: Transketolase, thiamine diphosphate binding domain. (275 aa) |
| | asnA | Aspartate/ammonia ligase; COGs: COG2502 Asparagine synthetase A; InterPro IPR000183:IPR004618:IPR006195; KEGG: bvu:BVU_4147 asparagine synthetase AsnA; PFAM: aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Aspartate-ammonia ligase; TIGRFAM: aspartate/ammonia ligase; manually curated; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type. (339 aa) |
| | ADK80324.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR001261:IPR002933:IPR011650; KEGG: sfu:Sfum_0989 peptidase M20; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Peptidase M20; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (368 aa) |
| | ADK80475.1 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220; KEGG: gym:GYMC10_3581 dihydrodipicolinate synthetase; PFAM: dihydrodipicolinate synthetase; SPTR: Dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (313 aa) |
| | ADK80483.1 | Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: tle:Tlet_0024 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; PFAM: Aminotransferase class I and II. (394 aa) |
| | ADK80509.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: pam:PANA_2380 FbaA; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: 5-dehydro-2-deoxyphosphogluconate aldolase; SPTR: FbaA; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (283 aa) |
| | ADK80511.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0498 Threonine synthase; InterPro IPR001926; KEGG: kol:Kole_2075 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Putative threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (406 aa) |
| | ADK80512.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: pmo:Pmob_1727 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme. (487 aa) |
| | ADK80540.1 | Amino-acid N-acetyltransferase; COGs: COG0548 Acetylglutamate kinase; InterPro IPR000209:IPR001048:IPR000182:IPR010167; KEGG: fsu:Fisuc_1504 amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; SPTR: Amino-acid N-acetyltransferase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; Amino acid kinase family; TIGRFAM: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. (449 aa) |
| | ADK80566.1 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR005946; KEGG: mmw:Mmwyl1_1169 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (389 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (351 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (196 aa) |
| | lysA | Orn/DAP/Arg decarboxylase 2; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | ADK80617.1 | PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013; KEGG: cpe:CPE0972 histidinol phosphatase; PFAM: PHP domain protein; SPTR: Probable histidinol phosphatase; manually curated; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (258 aa) |
| | ADK80731.1 | Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012846:IPR012001:IPR012000:IPR011766:IPR 000399; KEGG: tnp:Tnap_0328 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate [...] (558 aa) |
| | ADK80732.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: tnp:Tnap_0329 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (169 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404:IPR000581:IPR020558; KEGG: tpt:Tpet_0369 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (579 aa) |
| | ADK80735.1 | 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR013709:IPR002034; KEGG: tnp:Tnap_0332 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmal [...] (558 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (505 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (172 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa) |
| | ADK80748.1 | COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: tde:TDE0076 aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Fructose-bisphosphate aldolase; SPTR: Aldolase, DeoC/FbaB family; PFAM: DeoC/LacD family aldolase. (256 aa) |
| | ADK80768.1 | COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR000759:IPR013027:IPR017896; KEGG: dap:Dacet_0223 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Glutamate synthase (NADPH), homotetrameric; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (496 aa) |
| | ADK80798.1 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220:IPR020625; KEGG: bcv:Bcav_1435 dihydrodipicolinate synthetase; PFAM: dihydrodipicolinate synthetase; SPTR: Dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (306 aa) |
| | ADK80799.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: msu:MS0068 SerA protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: SerA protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (327 aa) |
| | ADK80811.1 | COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: mbu:Mbur_0414 serine O-acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase. (303 aa) |
| | ADK80985.1 | COGs: COG0176 Transaldolase; InterPro IPR018225; KEGG: bcx:BCA_3466 putative transaldolase; SPTR: Putative uncharacterized protein; PFAM: Transaldolase. (215 aa) |
| | pfkA | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (346 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa) |
| | ADK81028.1 | COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR016303:IPR002658; KEGG: reh:H16_A3434 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase protein; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase. (349 aa) |
| | ADK81168.1 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: sat:SYN_01763 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (220 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | ADK81258.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: min:Minf_1255 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (295 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (505 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (414 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (285 aa) |
| | argD | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814:IPR004636; KEGG: kol:Kole_0097 acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine transaminase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | ADK81359.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (354 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839:IPR005861; KEGG: sat:SYN_01517 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa) |
| | ADK81430.1 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR000583:IPR001962:IPR017932:IPR006426; KEGG: cyt:cce_4003 asparagine synthetase B; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: Asparagine synthase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferases class-II; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (500 aa) |
| | ADK81441.1 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR000759:IPR013027:IPR006005; KEGG: mab:MAB_0092 glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Probable NADH-dependent glutamate synthase (Small subunit) GltD; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. (466 aa) |
| | ADK81442.1 | COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583:IPR006982:IPR002932:IPR002489:IPR 017932; KEGG: sus:Acid_3816 glutamate synthase (NADH) large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1509 aa) |
| | ADK81466.1 | Aconitate hydratase; COGs: COG1048 Aconitase A; InterPro IPR001030:IPR018136:IPR000573:IPR006250; KEGG: hmo:HM1_0105 aconitate hydratase, putative; PFAM: aconitate hydratase domain protein; SPTR: Aconitase; TIGRFAM: aconitate hydratase; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, putative, Aquifex type. (648 aa) |
| | ADK81507.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: phe:Phep_3505 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Putative uncharacterized protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (330 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | pgk-2 | COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576:IPR015911; KEGG: bhr:BH0056 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa) |
| | ADK81559.1 | COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterProIPR020832:IPR020830:IPR020828:IPR020829:IPR 020831:IPR006424; KEGG: bga:BG0056 glyceraldehyde 3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: Glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; [...] (333 aa) |
| | ADK81650.1 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: mta:Moth_1122 citrate synthase; PFAM: Citrate synthase; SPTR: Citrate (Si)-synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (450 aa) |
| | ADK81698.1 | Fructose-1,6-bisphosphate aldolase, class II; COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771:IPR011289; KEGG: tpp:TPASS_0662 fructose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Fructose-bisphosphate aldolase; SPTR: Fructose-bisphosphate aldolase; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (332 aa) |
| | ADK81752.1 | Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR004010; KEGG: drt:Dret_2092 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; Cache domain protein; SPTR: Pyruvate carboxyltransferase; PFAM: Cache domain; HMGL-like. (608 aa) |
| | ADK81769.1 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR003500:IPR004785; KEGG: cno:NT01CX_0543 ribose-5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. (148 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | ADK81835.1 | COGs: COG0078 Ornithine carbamoyltransferase; InterPro IPR006130:IPR006132:IPR006131:IPR002082; KEGG: mta:Moth_1996 ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Ornithine carbamoyltransferase; SPTR: Ornithine carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; probable carbamoyltransferase YgeW; Belongs [...] (326 aa) |
| | ADK81843.1 | COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: tde:TDE0076 aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; SPTR: Putative uncharacterized protein; PFAM: DeoC/LacD family aldolase. (262 aa) |
| | ADK81856.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mtp:Mthe_0111 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (166 aa) |
| | ADK81857.1 | Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: mac:MA3792 acetolactate synthase 3 catalytic subunit; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-termina [...] (557 aa) |
| | ADK81874.1 | COGs: COG0527 Aspartokinase; InterProIPR001341:IPR001048:IPR002912:IPR005106:IPR 001342:IPR011147:IPR001412:IPR019811; KEGG: sru:SRU_0691 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Bifunctional aspartokinase/homoserine dehydrogenase I; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain; Amino acid kinase family; TIGRFAM: glutamate--cysteine ligase/gamma-glut [...] (824 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (492 aa) |
| | ADK81959.1 | Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR004439:IPR001804:IPR019818; KEGG: aac:Aaci_2348 isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (404 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (366 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (313 aa) |
| | ADK82053.1 | COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: dba:Dbac_1638 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases. (311 aa) |
| | ADK82093.1 | Transketolase domain protein; COGs: COG3958 Transketolase C-terminal subunit; InterPro IPR005475:IPR005476; KEGG: kol:Kole_0992 transketolase domain protein; PFAM: Transketolase domain protein; Transketolase central region; SPTR: Transketolase domain protein; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (319 aa) |
| | ADK82094.1 | Transketolase domain protein; COGs: COG3959 Transketolase N-terminal subunit; InterPro IPR005474; KEGG: kol:Kole_0993 transketolase domain protein; PFAM: Transketolase domain protein; SPTR: Transketolase domain protein; PFAM: Transketolase, thiamine diphosphate binding domain. (280 aa) |
| | hisZ | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (362 aa) |
| | ADK82239.1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (213 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807:IPR020565; KEGG: msl:Msil_2554 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (196 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518:IPR018223; KEGG: sti:Sthe_3259 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (423 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (456 aa) |
| | ADK82378.1 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: bbt:BBta_2804 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (362 aa) |
| | ADK82483.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: cdl:CDR20291_2979 putative sugar-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Putative uncharacterized protein; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (287 aa) |
| | ADK82488.1 | Conserved hypothetical protein; COGs: COG4809 ADP-dependent phosphofructokinase/glucokinase; InterPro IPR007666; KEGG: hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: ADP-specific Phosphofructokinase/Glucokinase conserved region. (400 aa) |
| | ADK82539.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: tit:Thit_0120 fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (282 aa) |
| | ADK82572.1 | COGs: COG0136 Aspartate-semialdehyde dehydrogenase; InterProIPR000534:IPR012280:IPR000319:IPR012080:IPR 005676; KEGG: tro:trd_0366 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase dimerisation region; Semialdehyde dehydrogenase NAD - binding; PRIAM: Aspartate-semialdehyde dehydrogenase; SPTR: Aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); Belongs to [...] (377 aa) |
| | ADK82599.1 | Fructose-bisphosphate aldolase class-I; COGs: COG3588 Fructose-1 6-bisphosphate aldolase; InterPro IPR000741; KEGG: fjo:Fjoh_0953 fructose-1,6-bisphosphate aldolase; PFAM: fructose-bisphosphate aldolase class-I; SPTR: Fructose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-I. (295 aa) |
| | pfp-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (393 aa) |
| | ADK82714.1 | Transaldolase; COGs: COG0176 Transaldolase; InterPro IPR018225; KEGG: mes:Meso_3212 putative translaldolase; SPTR: Probable transaldolase; PFAM: Transaldolase. (216 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa) |
| | argH | COGs: COG0165 Argininosuccinate lyase; InterPro IPR009049:IPR020557:IPR000362:IPR003031; KEGG: ttr:Tter_0314 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (454 aa) |
| | ADK82820.1 | COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR018300:IPR001544:IPR005786; KEGG: bgr:Bgr_12240 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain-amino-acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (363 aa) |
| | ADK82824.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR006139; KEGG: gka:GK1954 dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (329 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | ADK82996.1 | COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: cbe:Cbei_0444 glutamine synthetase, catalytic region; PFAM: glutamine synthetase catalytic region; SPTR: Glutamine synthetase catalytic region; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal. (711 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | ADK83025.1 | COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: bhy:BHWA1_00425 L-allo-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: Threonine aldolase; PFAM: Beta-eliminating lyase. (343 aa) |
| | ADK83052.1 | Chorismate mutase, type II; InterPro IPR020822:IPR002701; KEGG: gva:HMPREF0424_0113 chorismate mutase; PFAM: Chorismate mutase, type II; SPTR: Chorismate mutase; manually curated; PFAM: Chorismate mutase type II; TIGRFAM: monofunctional chorismate mutase, alpha proteobacterial type. (96 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (331 aa) |
| | ADK83077.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0498 Threonine synthase; InterPro IPR001926; KEGG: tvo:TVN0071 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (378 aa) |
| | ADK83081.1 | Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839:IPR004838:IPR001176; KEGG: fjo:Fjoh_2271 aspartate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aspartate aminotransferase; PFAM: Aminotransferase class I and II. (400 aa) |
| | ADK83101.1 | Biotin/lipoyl attachment domain-containing protein; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891:IPR000089:IPR001882; KEGG: dsa:Desal_0778 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; SPTR: Biotin/lipoyl attachment domain-containing protein; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme. (600 aa) |
| | ADK83111.1 | COGs: COG0136 Aspartate-semialdehyde dehydrogenase; InterPro IPR000534:IPR012280:IPR005676:IPR012080; KEGG: fpl:Ferp_1128 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; PRIAM: Aspartate-semialdehyde dehydrogenase; SPTR: Aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); Belongs to the aspar [...] (344 aa) |
| | ADK83200.1 | COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR006805:IPR015890:IPR019999; KEGG: fsu:Fisuc_0137 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: Anthranilate synthase component 1; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme. (480 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (541 aa) |
| | trpF | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798:IPR001240:IPR001468:IPR018208; KEGG: fsu:Fisuc_0176 indole-3-glycerol-phosphate synthase., phosphoribosylanthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate isomerase (PRAI); SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (526 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | ADK83279.1 | 6-phospho-3-hexuloisomerase; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR001347; KEGG: lbr:LVIS_0443 sugar phosphate isomerase; PFAM: sugar isomerase (SIS); PRIAM: 6-phospho-3-hexuloisomerase; SPTR: Putative uncharacterized protein; PFAM: SIS domain; TIGRFAM: 6-phospho 3-hexuloisomerase. (187 aa) |
| | hisA | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062:IPR006063; KEGG: syf:Synpcc7942_1829 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PF [...] (250 aa) |
| | hisE | COGs: COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; InterPro IPR008179; KEGG: bay:RBAM_032070 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. (197 aa) |
| | ADK83358.1 | Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR003171; KEGG: sus:Acid_7115 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase. (615 aa) |
| | ADK83359.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
