(65 nodes) Mixed, incl. Membrane coat, and Dynamin-type guanine nucleotide-binding (G) domain network (Thermothelomyces thermophilus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYCTH_2294115	PX domain-containing protein. (359 aa)
	MYCTH_2296126	ENTH domain-containing protein. (640 aa)
	MYCTH_2298240	Uncharacterized protein. (1050 aa)
	MYCTH_2294574	Uncharacterized protein. (213 aa)
	MYCTH_2296480	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (800 aa)
	MYCTH_2298570	WD_REPEATS_REGION domain-containing protein. (658 aa)
	MYCTH_62175	Glycosidase; Belongs to the glycosyl hydrolase 16 family. (424 aa)
	MYCTH_2296713	Uncharacterized protein. (323 aa)
	MYCTH_2054491	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
	MYCTH_2296824	Sortilin; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. (1525 aa)
	MYCTH_76367	ENTH domain-containing protein. (511 aa)
	MYCTH_2297208	Uncharacterized protein. (349 aa)
	MYCTH_2299299	Mitochondrial fission 1 protein; Has a role in mitochondrial fission. (153 aa)
	MYCTH_2132825	DUF1681 domain-containing protein. (342 aa)
	MYCTH_2295647	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1683 aa)
	MYCTH_2299445	CFEM domain-containing protein. (171 aa)
	MYCTH_2297705	Rab-GAP TBC domain-containing protein. (1172 aa)
	MYCTH_2074326	RING-CH-type domain-containing protein. (526 aa)
	MYCTH_2293999	PX domain-containing protein. (483 aa)
	MYCTH_2302341	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (701 aa)
	MYCTH_2300655	Adaptin_N domain-containing protein. (802 aa)
	MYCTH_2300657	Uncharacterized protein. (53 aa)
	MYCTH_2300799	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (918 aa)
	MYCTH_2302705	Uncharacterized protein. (283 aa)
	MYCTH_2301622	Uncharacterized protein. (522 aa)
	MYCTH_100541	Extracellular membrane-like protein. (97 aa)
	MYCTH_2301753	BAR domain-containing protein. (447 aa)
	MYCTH_2299965	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (448 aa)
	MYCTH_80081	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (437 aa)
	MYCTH_2300125	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	MYCTH_2301910	CFEM domain-containing protein. (231 aa)
	MYCTH_2301911	Uncharacterized protein. (1002 aa)
	MYCTH_2301968	PX domain-containing protein. (603 aa)
	MYCTH_2314800	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (239 aa)
	MYCTH_2300355	Peptidase_M48 domain-containing protein. (391 aa)
	MYCTH_2302119	AP-1 complex subunit gamma. (839 aa)
	MYCTH_2304626	EH domain-containing protein. (915 aa)
	MYCTH_2304663	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (929 aa)
	MYCTH_2305048	Uncharacterized protein. (1470 aa)
	MYCTH_2079097	Glycosidase; Belongs to the glycosyl hydrolase 16 family. (446 aa)
	MYCTH_2305149	PX domain-containing protein. (609 aa)
	MYCTH_2305350	Uncharacterized protein. (381 aa)
	MYCTH_2305439	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (647 aa)
	MYCTH_2304395	Uncharacterized protein. (789 aa)
	MYCTH_2306915	ENTH domain-containing protein. (593 aa)
	MYCTH_2307451	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (558 aa)
	MYCTH_2306125	Apple domain-containing protein. (313 aa)
	MYCTH_2306157	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (960 aa)
	MYCTH_2308165	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (758 aa)
	MYCTH_2309755	Rad60-SLD_2 domain-containing protein. (244 aa)
	MYCTH_2309758	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (746 aa)
	MYCTH_2309915	PX domain-containing protein. (632 aa)
	MYCTH_2310036	Uncharacterized protein. (399 aa)
	MYCTH_2310471	Adaptin_N domain-containing protein. (748 aa)
	MYCTH_74487	MHD domain-containing protein. (863 aa)
	MYCTH_2310754	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (888 aa)
	MYCTH_2084007	PX domain-containing protein. (189 aa)
	MYCTH_2120498	Uncharacterized protein. (244 aa)
	MYCTH_2097778	CHZ domain-containing protein. (330 aa)
	MYCTH_2312934	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (194 aa)
	MYCTH_2312943	Uncharacterized protein. (1316 aa)
	MYCTH_2313107	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (905 aa)
	MYCTH_2311547	Uncharacterized protein. (92 aa)
	MYCTH_2311548	Alpha_adaptinC2 domain-containing protein. (701 aa)
	MYCTH_2311907	Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family. (207 aa)

Your Current Organism:

Thermothelomyces thermophilus

NCBI taxonomy Id: 573729
Other names: Myceliophthora thermophila ATCC 42464, Sporotrichum thermophile ATCC 42464, T. thermophilus ATCC 42464, Thermothelomyces thermophilus ATCC 42464, Thielavia heterothallica ATCC 42464

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYCTH_100541	MYCTH_2295647	G2QA10	G2Q5U2	Extracellular membrane-like protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.475
MYCTH_100541	MYCTH_2300125	G2QA10	G2QAG5	Extracellular membrane-like protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.453
MYCTH_100541	MYCTH_2300655	G2QA10	G2Q7V7	Extracellular membrane-like protein.	Adaptin_N domain-containing protein.	0.655
MYCTH_100541	MYCTH_2300657	G2QA10	G2Q7V8	Extracellular membrane-like protein.	Uncharacterized protein.	0.655
MYCTH_100541	MYCTH_2302119	G2QA10	G2QB60	Extracellular membrane-like protein.	AP-1 complex subunit gamma.	0.638
MYCTH_100541	MYCTH_2307451	G2QA10	G2QFW4	Extracellular membrane-like protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.700
MYCTH_100541	MYCTH_2311547	G2QA10	G2QPA1	Extracellular membrane-like protein.	Uncharacterized protein.	0.488
MYCTH_100541	MYCTH_2312934	G2QA10	G2QNF9	Extracellular membrane-like protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.789
MYCTH_100541	MYCTH_2314800	G2QA10	G2QB04	Extracellular membrane-like protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.406
MYCTH_2054491	MYCTH_2132825	G2Q2X2	G2Q5R9	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	DUF1681 domain-containing protein.	0.851
MYCTH_2054491	MYCTH_2295647	G2Q2X2	G2Q5U2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.921
MYCTH_2054491	MYCTH_2296126	G2Q2X2	G2Q0I7	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	ENTH domain-containing protein.	0.662
MYCTH_2054491	MYCTH_2296480	G2Q2X2	G2Q1W0	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.569
MYCTH_2054491	MYCTH_2299965	G2Q2X2	G2QA34	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.668
MYCTH_2054491	MYCTH_2300125	G2Q2X2	G2QAG5	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.438
MYCTH_2054491	MYCTH_2300655	G2Q2X2	G2Q7V7	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptin_N domain-containing protein.	0.906
MYCTH_2054491	MYCTH_2300657	G2Q2X2	G2Q7V8	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Uncharacterized protein.	0.860
MYCTH_2054491	MYCTH_2300799	G2Q2X2	G2Q884	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.569
MYCTH_2054491	MYCTH_2301753	G2Q2X2	G2QA22	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	BAR domain-containing protein.	0.660
MYCTH_2054491	MYCTH_2301911	G2Q2X2	G2QAL1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Uncharacterized protein.	0.614

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