(56 nodes) Nuclear export network (Thermothelomyces thermophilus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYCTH_2305200	Uncharacterized protein. (854 aa)
	MYCTH_2118512	Uncharacterized protein. (353 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (246 aa)
	MYCTH_2315249	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (260 aa)
	MYCTH_2304677	Ran-specific GTPase-activating protein 1-like protein. (270 aa)
	MYCTH_2304673	Uncharacterized protein. (899 aa)
	MYCTH_2301997	SAP domain-containing protein. (328 aa)
	MYCTH_2300154	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1416 aa)
	MYCTH_2301840	Uncharacterized protein. (633 aa)
	MYCTH_2301474	Uncharacterized protein. (535 aa)
	MYCTH_2314890	WD_REPEATS_REGION domain-containing protein. (357 aa)
	MYCTH_78319	Protein kinase domain-containing protein. (786 aa)
	MYCTH_2300672	Uncharacterized protein. (1671 aa)
	MYCTH_2302424	Uncharacterized protein. (390 aa)
	MYCTH_2302422	CP-type G domain-containing protein. (648 aa)
	MYCTH_2302387	Uncharacterized protein. (837 aa)
	MYCTH_2302354	Importin N-terminal domain-containing protein. (959 aa)
	MYCTH_2295771	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (202 aa)
	MYCTH_2295512	Uncharacterized protein. (281 aa)
	MYCTH_2132763	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (659 aa)
	MYCTH_2297256	J domain-containing protein. (446 aa)
	MYCTH_2297229	TFIIS N-terminal domain-containing protein. (431 aa)
	MYCTH_2295275	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (627 aa)
	MYCTH_2141486	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (215 aa)
	MYCTH_2294815	Uncharacterized protein. (401 aa)
	MYCTH_2298612	Uncharacterized protein. (562 aa)
	MYCTH_77195	Uncharacterized protein. (345 aa)
	MYCTH_110536	RPOL4c domain-containing protein. (146 aa)
	MYCTH_75824	Uncharacterized protein; Belongs to the heat shock protein 70 family. (615 aa)
	MYCTH_2296410	Uncharacterized protein. (648 aa)
	MYCTH_2296345	Uncharacterized protein. (509 aa)
	MYCTH_2296320	CP-type G domain-containing protein. (568 aa)
	MYCTH_2294293	PCI domain-containing protein. (474 aa)
	MYCTH_86520	Uncharacterized protein. (214 aa)
	MYCTH_2309332	Importin N-terminal domain-containing protein. (1096 aa)
	MYCTH_2308539	FHA domain-containing protein. (326 aa)
	MYCTH_2308660	U3 small nucleolar RNA-associated protein 22. (1122 aa)
	MYCTH_2309781	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (437 aa)
	MYCTH_2310189	Uncharacterized protein. (2474 aa)
	MYCTH_109876	Uncharacterized protein. (94 aa)
	MYCTH_2311147	Uncharacterized protein. (1116 aa)
	MYCTH_2312891	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (749 aa)
	MYCTH_2312962	Ribosomal_S7 domain-containing protein; Belongs to the universal ribosomal protein uS7 family. (212 aa)
	MYCTH_2311279	Uncharacterized protein. (618 aa)
	MYCTH_2311912	Importin N-terminal domain-containing protein. (1076 aa)
	MYCTH_2312029	Uncharacterized protein. (798 aa)
	MYCTH_2316574	RRM domain-containing protein. (254 aa)
	MYCTH_2303495	Guanylate kinase-like domain-containing protein. (712 aa)
	MYCTH_2303666	Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (1020 aa)
	MYCTH_2307409	E3 ubiquitin-protein ligase. (811 aa)
	MYCTH_2306302	Uncharacterized protein. (642 aa)
	MYCTH_2306674	YTH domain-containing protein. (384 aa)
	MYCTH_2309107	Uncharacterized protein. (502 aa)
	MYCTH_2309153	Importin N-terminal domain-containing protein. (1278 aa)
	MYCTH_2309198	Uncharacterized protein. (382 aa)
	MYCTH_2135338	C2H2-type domain-containing protein. (114 aa)

Your Current Organism:

Thermothelomyces thermophilus

NCBI taxonomy Id: 573729
Other names: Myceliophthora thermophila ATCC 42464, Sporotrichum thermophile ATCC 42464, T. thermophilus ATCC 42464, Thermothelomyces thermophilus ATCC 42464, Thielavia heterothallica ATCC 42464

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYCTH_109876	MYCTH_2294293	G2QLD7	G2Q0T3	Uncharacterized protein.	PCI domain-containing protein.	0.970
MYCTH_109876	MYCTH_2298612	G2QLD7	G2Q2K4	Uncharacterized protein.	Uncharacterized protein.	0.972
MYCTH_109876	MYCTH_2300672	G2QLD7	G2Q7W4	Uncharacterized protein.	Uncharacterized protein.	0.965
MYCTH_109876	MYCTH_2316574	G2QLD7	G2QQ08	Uncharacterized protein.	RRM domain-containing protein.	0.494
MYCTH_110536	MYCTH_2141486	G2Q2B3	G2Q334	RPOL4c domain-containing protein.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.613
MYCTH_110536	MYCTH_2297229	G2Q2B3	G2Q514	RPOL4c domain-containing protein.	TFIIS N-terminal domain-containing protein.	0.483
MYCTH_110536	MYCTH_2300154	G2Q2B3	G2QAH7	RPOL4c domain-containing protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.945
MYCTH_110536	MYCTH_2311279	G2Q2B3	G2QNQ9	RPOL4c domain-containing protein.	Uncharacterized protein.	0.477
MYCTH_2118512	MYCTH_2141486	G2QBW4	G2Q334	Uncharacterized protein.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.586
MYCTH_2118512	MYCTH_2294293	G2QBW4	G2Q0T3	Uncharacterized protein.	PCI domain-containing protein.	0.448
MYCTH_2118512	MYCTH_2294815	G2QBW4	G2Q2P6	Uncharacterized protein.	Uncharacterized protein.	0.412
MYCTH_2118512	MYCTH_2296410	G2QBW4	G2Q1H7	Uncharacterized protein.	Uncharacterized protein.	0.990
MYCTH_2118512	MYCTH_2300672	G2QBW4	G2Q7W4	Uncharacterized protein.	Uncharacterized protein.	0.420
MYCTH_2118512	MYCTH_2301474	G2QBW4	G2Q9L3	Uncharacterized protein.	Uncharacterized protein.	0.887
MYCTH_2118512	MYCTH_2302387	G2QBW4	G2Q7P7	Uncharacterized protein.	Uncharacterized protein.	0.744
MYCTH_2118512	MYCTH_2303495	G2QBW4	G2QCX0	Uncharacterized protein.	Guanylate kinase-like domain-containing protein.	0.424
MYCTH_2118512	MYCTH_2304673	G2QBW4	G2QBH0	Uncharacterized protein.	Uncharacterized protein.	0.586
MYCTH_2118512	MYCTH_2304677	G2QBW4	G2QBH1	Uncharacterized protein.	Ran-specific GTPase-activating protein 1-like protein.	0.586
MYCTH_2118512	MYCTH_2311912	G2QBW4	G2QPT6	Uncharacterized protein.	Importin N-terminal domain-containing protein.	0.471
MYCTH_2118512	MYCTH_2314890	G2QBW4	G2Q849	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.905

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