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| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (410 aa) |
| | pheT | COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR012340:IPR020825:IPR005147:IPR005121:IPR 002547:IPR016027:IPR009061:IPR004532:IPR005146; KEGG: hor:Hore_05640 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: B8D294 Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA syn [...] (799 aa) |
| | pheS | COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterProIPR016160:IPR006195:IPR010978:IPR004529:IPR 004188:IPR002319; KEGG: hor:Hore_05630 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; PRIAM: Phenylalanine--tRNA ligase; SPTR: B8D293 Phenylalanyl-tRNA synthetase, alpha subunit; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subun [...] (339 aa) |
| | thrS | Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (639 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (569 aa) |
| | ADL11907.1 | InterPro IPR016040; KEGG: dae:Dtox_0030 hypothetical protein; SPTR: C1TAS5 Putative uncharacterized protein. (268 aa) |
| | ADL11906.1 | Protein of unknown function DUF201; COGs: COG0439 Biotin carboxylase; InterProIPR013817:IPR011761:IPR016185:IPR016040:IPR 006076:IPR003806; KEGG: dhd:Dhaf_4856 protein of unknown function DUF201; PFAM: protein of unknown function DUF201; FAD dependent oxidoreductase; SPTR: Q24MJ6 Putative uncharacterized protein; PFAM: Pyridine nucleotide-disulphide oxidoreductase; ATP-grasp domain. (390 aa) |
| | ADL11903.1 | Pyrrolysyl-tRNA synthetase; InterPro IPR006195:IPR002314; KEGG: dae:Dtox_0027 Pyrrolysine-tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); PRIAM: Pyrrolysine--tRNA(Pyl) ligase; SPTR: C1TAS2 Lysyl-tRNA synthetase (Class II); PFAM: tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: pyrrolysyl-tRNA synthetase. (279 aa) |
| | ADL11902.1 | KEGG: dat:HRM2_15230 hypothetical protein; SPTR: C0Q9R8 Putative uncharacterized protein. (94 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (317 aa) |
| | ADL11878.1 | Ferredoxin; COGs: COG3894 Uncharacterized metal-binding protein; InterPro IPR012675:IPR001041; KEGG: dhd:Dhaf_3310 ferredoxin; PFAM: ferredoxin; SPTR: C6PA24 Vitamin B12 dependent methionine synthase activation region; PFAM: 2Fe-2S iron-sulfur cluster binding domain. (611 aa) |
| | ADL11763.1 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR002034:IPR000891:IPR013709:IPR013785:IPR 005675; KEGG: pfu:PF0941 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: Q8U298 Leua homolog alpha-isopropylmalate synthase related; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to [...] (525 aa) |
| | ADL11762.1 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818:IPR001804; KEGG: hor:Hore_10890 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: B8CX24 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase. (348 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | ADL11757.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (160 aa) |
| | ADL11756.1 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] (578 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR020558:IPR000581:IPR004404; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C7HB79 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | cysS | COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR015803:IPR015273:IPR014729:IPR009080:IPR 002308; KEGG: cth:Cthe_2065 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; SPTR: C7HE23 Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (481 aa) |
| | ADL11691.1 | COGs: COG1045 Serine acetyltransferase; InterPro IPR001451:IPR011004:IPR005881; KEGG: chy:CHY_2339 serine acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: C6PB49 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase. (223 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (488 aa) |
| | ADL13543.1 | Isocitrate dehydrogenase, NAD-dependent; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR004434:IPR019818:IPR001804; KEGG: hor:Hore_08060 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: C6PZB2 Isocitrate dehydrogenase (NAD(+)); TIGRFAM: isocitrate dehydrogenase, NAD-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokar [...] (331 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (117 aa) |
| | ADL11614.1 | Sulfide dehydrogenase (flavoprotein) subunit SudA; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR012285:IPR009051:IPR006004; KEGG: dhd:Dhaf_3501 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: B8FQ58 Glutamate synthase (NADPH), homotetrameric; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (458 aa) |
| | ADL11612.1 | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterProIPR006097:IPR006096:IPR016040:IPR006095:IPR 014362; KEGG: cth:Cthe_0374 glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: C6P885 Glutamate dehydrogenase (NADP(+)); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (644 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | ADL11579.1 | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterProIPR006139:IPR006140:IPR002912:IPR016040:IPR 006236; KEGG: hor:Hore_11540 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: B8CX87 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic [...] (527 aa) |
| | ADL13820.1 | Cysteine desulfurase family protein; COGs: COG0520 Selenocysteine lyase; InterProIPR020578:IPR000192:IPR015424:IPR015421:IPR 010969; KEGG: aoe:Clos_2866 cysteine desulfurase family protein; PFAM: aminotransferase class V; SPTR: A8MKR3 Cysteine desulfurase family protein; TIGRFAM: cysteine desulfurase family protein; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein. (383 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (232 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (283 aa) |
| | ADL13779.1 | CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR002731:IPR008275; KEGG: cdf:CD0396 activator of 2-hydroxyisocaproyl-CoA dehydratase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; PRIAM: Benzoyl-CoA reductase; SPTR: Q1Q1I6 Putative uncharacterized protein; TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative. (255 aa) |
| | ADL13778.1 | COGs: COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit BcrC/BadD/HgdB; InterPro IPR010327; KEGG: mta:Moth_1418 2-hydroxyglutaryl-CoA dehydratase, D-component; PFAM: 2-hydroxyglutaryl-CoA dehydratase D-component; SPTR: Q2RIK8 2-hydroxyglutaryl-CoA dehydratase, D-component; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component. (425 aa) |
| | ADL13777.1 | C_GCAxxG_C_C family protein; InterPro IPR010181; KEGG: cpy:Cphy_1476 C_GCAxxG_C_C family protein; PFAM: C_GCAxxG_C_C family protein; SPTR: A9KPV1 C_GCAxxG_C_C family protein; TIGRFAM: C_GCAxxG_C_C family protein; PFAM: Putative redox-active protein (C_GCAxxG_C_C); TIGRFAM: C_GCAxxG_C_C family probable redox protein. (153 aa) |
| | ADL13774.1 | Rhodanese domain protein; COGs: COG2897 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: cbi:CLJ_B1188 putative thiosulfate sulfurtransferase; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: C3KT55 Putative thiosulfate sulfurtransferase; PFAM: Rhodanese-like domain. (592 aa) |
| | ADL13769.1 | COGs: COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit BcrC/BadD/HgdB; InterPro IPR010327; KEGG: cbi:CLJ_B3968 2-hydroxyglutaryl-CoA dehydratase, D-component; PFAM: 2-hydroxyglutaryl-CoA dehydratase D-component; SPTR: C6Q2L1 2-hydroxyglutaryl-CoA dehydratase D-component; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component. (385 aa) |
| | ADL13768.1 | CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR002731:IPR008275; KEGG: cdf:CD1750 putative (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit; PFAM: ATPase BadF/BadG/BcrA/BcrD type; PRIAM: Benzoyl-CoA reductase; SPTR: Q186V6 Putative (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit; TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative. (254 aa) |
| | ADL13733.1 | CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR002731:IPR008275; KEGG: pth:PTH_1325 activator of 2-hydroxyglutaryl-CoA dehydratase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; SPTR: A5D2M2 Activator of 2-hydroxyglutaryl-CoA dehydratase; TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative. (318 aa) |
| | argS | COGs: COG0018 Arginyl-tRNA synthetase; InterProIPR001412:IPR015945:IPR005148:IPR008909:IPR 009080:IPR014729:IPR001278; KEGG: dae:Dtox_0052 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Q2LVV5 Arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (561 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (530 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | glmS-2 | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa) |
| | ADL13584.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR010168:IPR002933:IPR011650:IPR017439; KEGG: ava:Ava_2218 peptidase M20D, amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: A1HTZ9 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (399 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (516 aa) |
| | lysS | COGs: COG1190 Lysyl-tRNA synthetase (class II); InterProIPR004365:IPR004364:IPR012340:IPR016027:IPR 018149:IPR006195:IPR002313; KEGG: hor:Hore_00750 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; SPTR: B8D082 Lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family. (491 aa) |
| | ADL13522.1 | Cysteine desulfurase family protein; COGs: COG0520 Selenocysteine lyase; InterProIPR010969:IPR020578:IPR000192:IPR015424:IPR 015421; KEGG: mta:Moth_2214 cysteine desulphurase-like protein; PFAM: aminotransferase class V; SPTR: Q2RGD6 Putative uncharacterized protein; TIGRFAM: cysteine desulfurase family protein; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein. (381 aa) |
| | ADL13506.1 | Alcohol dehydrogenase GroES domain protein; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149:IPR011032:IPR016040; KEGG: deb:DehaBAV1_0246 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: A5FSJ2 Alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (344 aa) |
| | ADL13487.1 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002932:IPR013785; KEGG: hor:Hore_17300 glutamate synthase (NADPH) large subunit; PFAM: ferredoxin-dependent glutamate synthase; SPTR: B8CYW0 Glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (471 aa) |
| | ADL13460.1 | COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: hor:Hore_23060 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: B8D199 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases. (308 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (675 aa) |
| | ADL13440.1 | COGs: COG3643 Glutamate formiminotransferase; InterPro IPR004227:IPR012886:IPR013802; KEGG: aoe:Clos_0580 glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein; PRIAM: Formimidoyltetrahydrofolate cyclodeaminase; SPTR: A8MLX5 Glutamate formiminotransferase; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain; TIGRFAM: glutamate formiminotransferase. (300 aa) |
| | hutI | COGs: COG1228 Imidazolonepropionase and related amidohydrolase; InterPro IPR005920:IPR006680:IPR011059; KEGG: ctc:CTC02320 imidazolonepropionase; PFAM: amidohydrolase; PRIAM: Imidazolonepropionase; SPTR: Q891P9 Imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: Amidohydrolase family; TIGRFAM: imidazolonepropionase; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (414 aa) |
| | hutH | COGs: COG2986 Histidine ammonia-lyase; InterPro IPR005921:IPR001106:IPR008948; KEGG: aoe:Clos_1187 histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; PRIAM: Histidine ammonia-lyase; SPTR: A8MF64 Histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: Phenylalanine and histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase. (513 aa) |
| | ADL13435.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR010168:IPR002933:IPR011650:IPR017439; KEGG: pho:PH1043 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: O58754 387aa long hypothetical amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (391 aa) |
| | ilvD-2 | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404:IPR020558:IPR000581; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C5EPY2 Dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (560 aa) |
| | ADL13408.1 | Amidohydrolase; COGs: COG1228 Imidazolonepropionase and related amidohydrolase; InterPro IPR006680:IPR011059; KEGG: mta:Moth_0462 amidohydrolase; PFAM: amidohydrolase; SPTR: Q2RL96 Amidohydrolase; PFAM: Amidohydrolase family. (402 aa) |
| | ADL13403.1 | COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: hmo:HM1_1923 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: B0TFQ1 Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (272 aa) |
| | ADL13383.1 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR010140:IPR004013:IPR016195:IPR003141; KEGG: hor:Hore_11520 histidinol-phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: B8CX85 Histidinol-phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (253 aa) |
| | ADL13374.1 | COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: hmo:HM1_1923 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA; SPTR: B0TFQ1 Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpC | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798:IPR011060:IPR013785; KEGG: amt:Amet_1080 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: A6TM74 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa) |
| | trpF | COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240:IPR011060:IPR013785; KEGG: gur:Gura_1736 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: C6MQI3 Phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (209 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | ADL13361.1 | LL-diaminopimelate aminotransferase apoenzyme; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838:IPR004839:IPR015424:IPR015421; KEGG: ate:Athe_0546 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: C6J3D0 Aminotransferase class I and II; PFAM: Aminotransferase class I and II. (413 aa) |
| | ADL13345.1 | COGs: COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase alpha subunit; InterPro IPR012792:IPR004165:IPR004163; KEGG: amt:Amet_4247 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase; PRIAM: Acetate CoA-transferase; SPTR: A6TVV7 3-oxoacid CoA-transferase, A subunit; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: Coenzyme A transferase; TIGRFAM: 3-oxoacid CoA-transferase, A subunit. (217 aa) |
| | ADL13344.1 | COGs: COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase beta subunit; InterPro IPR012791:IPR004165:IPR004164; KEGG: amt:Amet_4246 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase; PRIAM: Butyrate--acetoacetate CoA-transferase; SPTR: A6TVV6 3-oxoacid CoA-transferase, B subunit; TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: Coenzyme A transferase; TIGRFAM: 3-oxoacid CoA-transferase, B subunit. (219 aa) |
| | ADL13339.1 | COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR016040:IPR006139:IPR006140; KEGG: cno:NT01CX_0601 D-isomer specific 2-hydroxyacid dehydrogenases; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; PRIAM: Phosphoglycerate dehydrogenase; SPTR: C5VNM2 Putative glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (317 aa) |
| | ADL13338.1 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterProIPR017932:IPR006426:IPR014729:IPR000583:IPR 001962; KEGG: mta:Moth_1299 asparagine synthase, glutamine-hydrolyzing; PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: Q2RIX6 Asparagine synthase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (613 aa) |
| | ADL13332.1 | Glutamate synthase (NADPH) GltB1 subunit; COGs: COG0067 Glutamate synthase domain 1; InterPro IPR017932:IPR012375:IPR000583; KEGG: hor:Hore_16310 glutamate synthase (NADPH) GltB1 subunit; PFAM: glutamine amidotransferase class-II; SPTR: B8CYL1 Glutamate synthase (NADPH) GltB1 subunit; PFAM: Glutamine amidotransferases class-II. (365 aa) |
| | ADL13331.1 | Glutamate synthase (NADPH) GltB2 subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017896:IPR013785:IPR001450:IPR002932:IPR 017900; KEGG: hor:Hore_16300 glutamate synthase (NADPH); PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: Glutamate synthase (NADPH); SPTR: B8CYL0 Glutamate synthase (NADPH); PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (500 aa) |
| | ADL13328.1 | Glutamate synthase (NADPH) GltB3 subunit; COGs: COG0070 Glutamate synthase domain 3; InterPro IPR012061:IPR002489; KEGG: hor:Hore_16290 glutamate synthase (NADPH) GltB3 subunit; PFAM: glutamate synthase alpha subunit domain protein; SPTR: B8CYK9 Glutamate synthase (NADPH) GltB3 subunit; PFAM: GXGXG motif. (245 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (400 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (141 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (150 aa) |
| | ADL13222.1 | Alanine racemase domain protein; COGs: COG3457 amino acid racemase; InterPro IPR001608; KEGG: tpd:Teth39_1046 alanine racemase domain-containing protein; PFAM: alanine racemase domain protein; SPTR: B0K988 Alanine racemase domain protein; PFAM: Alanine racemase, N-terminal domain. (360 aa) |
| | ADL13200.1 | CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731; KEGG: tpd:Teth39_0552 putative CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; SPTR: C6PJ80 CoA-substrate-specific enzyme activase; TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative. (316 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (437 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (328 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (265 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | ADL13082.1 | COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048:IPR018042; KEGG: hor:Hore_08680 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: B8CWF5 Aspartokinase; TIGRFAM: aspartate kinase; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (407 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (287 aa) |
| | argD | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterProIPR004636:IPR015422:IPR015421:IPR005814:IPR 015424; KEGG: hor:Hore_02850 acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: B8D1G9 Acetylornithine and succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (396 aa) |
| | carA-2 | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR002474:IPR006274:IPR017926:IPR000991:IPR 001317:IPR011702:IPR006220; KEGG: amt:Amet_4211 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: A6TVS3 Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (359 aa) |
| | carB-2 | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR016185:IPR005480:IPR006275:IPR011761:IPR 005481:IPR005479:IPR011607:IPR013817:IPR013816:IPR005483; KEGG: cth:Cthe_1868 carbamoyl-phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: A3DGL0 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L [...] (1067 aa) |
| | ADL13039.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518:IPR014729:IPR018223; KEGG: hor:Hore_02900 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: B8D1H4 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argH | COGs: COG0165 Argininosuccinate lyase; InterProIPR008948:IPR009049:IPR000362:IPR020557:IPR 003031; KEGG: pca:Pcar_2418 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Q3A1V0 Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (456 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (192 aa) |
| | hisS-2 | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (420 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (218 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR020568:IPR000807:IPR020565; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: C7HI03 Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR011060:IPR006063:IPR006062:IPR013785; KEGG: syp:SYNPCC7002_A1890 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: A3ISI1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methyli [...] (243 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496; KEGG: dae:Dtox_0758 phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: C1TDK3 Phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (240 aa) |
| | ADL12937.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (375 aa) |
| | ADL12922.1 | CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731; KEGG: cbi:CLJ_B1663 putative CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; SPTR: C3KVW0 Putative CoA-substrate-specific enzyme activase; TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative. (253 aa) |
| | ADL12916.1 | Protein of unknown function DUF161; COGs: COG2364 membrane protein; InterPro IPR003740; KEGG: bha:BH1258 hypothetical protein; PFAM: protein of unknown function DUF161; SPTR: Q9KDF5 BH1258 protein; PFAM: Uncharacterized BCR, YitT family COG1284. (196 aa) |
| | ADL12905.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR011650:IPR010168:IPR002933:IPR017439; KEGG: ton:TON_0348 bifunctional carboxypeptidase/aminoacylase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: C4CJY7 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (393 aa) |
| | ADL12873.1 | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR015424:IPR005814:IPR015421:IPR010916; KEGG: tth:TTC0553 ornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: A1HTU7 Acetylornithine and succinylornithine aminotransferases; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa) |
| | ADL12849.1 | InterPro IPR004223; KEGG: tpd:Teth39_0998 vitamin B12 dependent methionine synthase, activation region; PFAM: Vitamin B12 dependent methionine synthase activation region; SPTR: B0K940 Vitamin B12 dependent methionine synthase, activation region; PFAM: Vitamin B12 dependent methionine synthase, activation domain. (224 aa) |
| | ADL12815.1 | Ferredoxin; COGs: COG3894 Uncharacterized metal-binding protein; InterPro IPR001041:IPR012675; KEGG: dhd:Dhaf_2795 ferredoxin; PFAM: ferredoxin; SPTR: C0GF45 Ferredoxin; PFAM: 2Fe-2S iron-sulfur cluster binding domain. (644 aa) |
| | ADL12812.1 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR011005:IPR000489; KEGG: chy:CHY_1227 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Q3ACR9 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; PFAM: Pterin binding enzyme. (262 aa) |
| | ADL12798.1 | COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterProIPR015424:IPR000192:IPR015421:IPR020578:IPR 016454; KEGG: tpd:Teth39_0797 aminotransferase, class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: B0K8J1 Aminotransferase, class V; PFAM: Aminotransferase class-V. (386 aa) |
| | ADL12794.1 | L-lysine 2,3-aminomutase; COGs: COG1509 Lysine 2 3-aminomutase; InterPro IPR003739:IPR007197; KEGG: dae:Dtox_0600 lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; PRIAM: Lysine 2,3-aminomutase; SPTR: A8MLR3 Lysine 2,3-aminomutase YodO family protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Lysine-2,3-aminomutase; Radical SAM superfamily; TIGRFAM: KamA family protein. (401 aa) |
| | ADL12793.1 | InterPro IPR016181:IPR000182; KEGG: mbu:Mbur_0273 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Q12Z48 Acetyltransferase (GNAT) family protein; PFAM: Acetyltransferase (GNAT) family. (292 aa) |
| | ADL12785.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR011005:IPR000489; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | ADL12774.1 | Orn/DAP/Arg decarboxylase 2; COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR009006:IPR000183:IPR002986; KEGG: drm:Dred_3249 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2; SPTR: A4J9J6 Diaminopimelate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase. (412 aa) |
| | ADL12739.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | ADL12731.1 | COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: nth:Nther_1932 thiamine pyrophosphate protein TPP binding domain protein; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B2A6H0 Thiamine pyrophosphate protein TPP binding domain protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (541 aa) |
| | hisC-2 | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR005861:IPR001917:IPR015424:IPR004839:IPR 015421; KEGG: nth:Nther_1931 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: B2A6G9 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (378 aa) |
| | ADL12668.1 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterProIPR006235:IPR000277:IPR000209:IPR015424:IPR 015421:IPR015422; KEGG: hor:Hore_19570 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; SPTR: B8CZI5 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase; OAH/OAS sulfhydrylase; O-succinylhomoserine sulfhydrylase. (398 aa) |
| | ADL12627.1 | COGs: COG0498 Threonine synthase; InterPro IPR004450:IPR000634:IPR001926; KEGG: cth:Cthe_1381 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: A3DF84 L-threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (497 aa) |
| | ADL12598.1 | Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR000489:IPR011005; KEGG: drm:Dred_2207 homocysteine S-methyltransferase; PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; SPTR: A4J6L9 Methionine synthase (B12-dependent); PFAM: Pterin binding enzyme; Homocysteine S-methyltransferase. (562 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (299 aa) |
| | ADL12596.1 | COGs: COG0527 Aspartokinase; InterProIPR005260:IPR001341:IPR018042:IPR001048:IPR 002912; KEGG: drm:Dred_1167 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A4J3P8 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (413 aa) |
| | ADL12595.1 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR016204:IPR019811:IPR016040:IPR005106:IPR 001342:IPR002912; KEGG: dae:Dtox_2114 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: C1TG46 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (429 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (291 aa) |
| | ADL12582.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005:IPR002856; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | ADL12556.1 | COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099:IPR016040:IPR002912; KEGG: hmo:HM1_1926 prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydrogenase; SPTR: B0TFQ3 Prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; ACT domain. (368 aa) |
| | ADL12555.1 | COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: tpd:Teth39_0984 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: C6Q6Z9 Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR005861:IPR015424:IPR004839:IPR001176:IPR 015421; KEGG: mta:Moth_0515 histidinol phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | ADL12553.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (122 aa) |
| | ADL12484.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | ADL12482.1 | Alcohol dehydrogenase GroES domain protein; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterProIPR002328:IPR011032:IPR016040:IPR013154:IPR 013149; KEGG: rba:RB5948 Zn-dependent alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: C6J3Q4 Alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase. (350 aa) |
| | ADL12475.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR016040:IPR006139; KEGG: mka:MK0297 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Q8TYK0 Predicted dehydrogenase related to phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (318 aa) |
| | ADL12465.1 | Protein of unknown function DUF126; COGs: COG1786 conserved hypothetical protein; InterPro IPR002840; KEGG: bch:Bcen2424_6625 hypothetical protein; PFAM: protein of unknown function DUF126; SPTR: A2W9E3 Putative uncharacterized protein; PFAM: Protein of unknown function DUF126. (141 aa) |
| | ADL12464.1 | Protein of unknown function DUF521; COGs: COG1679 conserved hypothetical protein; InterPro IPR007506; KEGG: vap:Vapar_3213 protein of unknown function DUF521; PFAM: protein of unknown function DUF521; SPTR: C5CQY6 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF521). (425 aa) |
| | ADL12462.1 | KEGG: ckr:CKR_1801 hypothetical protein; SPTR: B9E2X7 Putative uncharacterized protein; PFAM: Asp/Glu/Hydantoin racemase. (259 aa) |
| | ADL12461.1 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | ADL12457.1 | KEGG: ter:Tery_3123 hypothetical protein; SPTR: Q10ZR9 Putative uncharacterized protein; PFAM: Asp/Glu/Hydantoin racemase. (263 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005479:IPR005483:IPR013817:IPR013816:IPR 005481:IPR005480:IPR011607:IPR011761:IPR016185:IPR006275; KEGG: dae:Dtox_2352 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: C1T9B9 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase [...] (1070 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR001317:IPR011702:IPR006220:IPR002474:IPR 000991:IPR017926:IPR006274; KEGG: drm:Dred_1683 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: A4J557 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (360 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006130:IPR002082:IPR006132:IPR006131; KEGG: hor:Hore_09370 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase; SPTR: B8CWM4 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate c [...] (313 aa) |
| | ADL12421.1 | Cysteine desulfurase family protein; COGs: COG0520 Selenocysteine lyase; InterProIPR020578:IPR015421:IPR000192:IPR015424:IPR 010969; KEGG: cbi:CLJ_B3972 cysteine desulfurase family protein; PFAM: aminotransferase class V; SPTR: C3KWI5 Cysteine desulfurase family protein; TIGRFAM: cysteine desulfurase family protein; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein. (385 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (927 aa) |
| | ADL12416.1 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa) |
| | ADL12382.1 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR004838:IPR001176:IPR015421:IPR015422:IPR 004839:IPR015424:IPR005860; KEGG: dae:Dtox_3089 L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: C1TJJ7 L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. (368 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (462 aa) |
| | cobQ-2 | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (506 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (505 aa) |
| | ADL12337.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterProIPR017439:IPR001412:IPR002933:IPR011650:IPR 010168; KEGG: dth:DICTH_1768 thermostable carboxypeptidase 1; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: C4CJY7 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (393 aa) |
| | iscS | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (390 aa) |
| | ADL12267.1 | Protein of unknown function DUF161; COGs: COG2364 membrane protein; InterPro IPR003740; KEGG: bbe:BBR47_28180 hypothetical protein; PFAM: protein of unknown function DUF161; SPTR: C0ZDD6 Conserved hypothetical membrane protein; PFAM: Uncharacterized BCR, YitT family COG1284. (204 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa) |
| | hisS | COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR004516:IPR004154:IPR002314:IPR006195:IPR 015807; KEGG: hor:Hore_12150 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: B8CXE6 Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (420 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | pheA | COGs: COG0077 Prephenate dehydratase; InterPro IPR018528:IPR001086:IPR002912; KEGG: msi:Msm_1052 prephenate dehydratase, PheA; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: A5UM29 Prephenate dehydratase, PheA; PFAM: Prephenate dehydratase; ACT domain. (277 aa) |
| | glyS | COGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR002311:IPR008909:IPR006194:IPR015944; KEGG: hmo:HM1_2458 glycyl-tRNA synthetase, beta subunit; PFAM: glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain protein; PRIAM: Glycine--tRNA ligase; SPTR: B0TAF8 Glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit; PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit. (694 aa) |
| | glyQ | COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; InterPro IPR002310:IPR006194; KEGG: hmo:HM1_2457 glycyl-tRNA synthetase, alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: B0TAF7 Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit. (295 aa) |
| | ADL12179.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mma:MM_0669 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8PZ25 Acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (159 aa) |
| | ADL12178.1 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TP [...] (577 aa) |
| | ADL12169.1 | COGs: COG0520 Selenocysteine lyase; InterPro IPR020578:IPR015421:IPR000192:IPR015424; KEGG: swo:Swol_2429 cysteine desulfurase; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Q0AU86 Cysteine desulfurase; PFAM: Aminotransferase class-V. (457 aa) |
| | leuS | COGs: COG0495 Leucyl-tRNA synthetase; InterProIPR014729:IPR001412:IPR002302:IPR009008:IPR 009080:IPR015413:IPR013155; KEGG: hor:Hore_13370 leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); SPTR: B8CXR8 Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family. (828 aa) |
| | ADL12118.1 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dhd:Dhaf_0077 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Q251W5 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Methylene-tetrahydrofolate reductase C terminal. (521 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa) |
| | ADL12062.1 | L-asparaginase, type I; COGs: COG0252 L-asparaginase/ Glu-tRNAGln amidotransferase subunit D; InterPro IPR020827:IPR006034:IPR006033; KEGG: bcb:BCB4264_A3116 L-asparaginase; PFAM: Asparaginase/glutaminase; SPTR: B7AWH9 Putative uncharacterized protein; TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase; TIGRFAM: L-asparaginases, type I. (346 aa) |
| | ADL12060.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR001261:IPR011650:IPR002933; KEGG: sth:STH1479 putative peptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Q67PC9 Putative peptidase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (379 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa) |
| | ADL12040.1 | Conserved hypothetical protein; InterPro IPR018163; KEGG: hor:Hore_15400 hypothetical protein; SPTR: B8CYC0 Putative uncharacterized protein; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain. (299 aa) |
| | ADL12039.1 | Conserved hypothetical protein; InterPro IPR018163; KEGG: hor:Hore_15400 hypothetical protein; SPTR: B8CYC0 Putative uncharacterized protein. (299 aa) |
| | ADL12026.1 | COGs: COG3799 Methylaspartate ammonia-lyase; InterPro IPR006395; KEGG: hor:Hore_15430 methylaspartate ammonia-lyase; PFAM: methylaspartate ammonia-lyase; PRIAM: Methylaspartate ammonia-lyase; SPTR: B8CYC3 Methylaspartate ammonia-lyase; TIGRFAM: methylaspartate ammonia-lyase; PFAM: Methylaspartate ammonia-lyase C-terminus; Methylaspartate ammonia-lyase N-terminus; TIGRFAM: methylaspartate ammonia-lyase. (413 aa) |
| | glmE | Glutamate mutase subunit E; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (482 aa) |
| | glmS | Glutamate mutase subunit S; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (138 aa) |
| | ADL12019.1 | Selenium-dependent molybdenum hydroxylase system protein, YqeB family; InterPro IPR017695; KEGG: nth:Nther_2210 biotin/lipoyl attachment; SPTR: B2A804 Biotin/lipoyl attachment; TIGRFAM: selenium-dependent molybdenum hydroxylase system protein, YqeB family; TIGRFAM: selenium-dependent molybdenum hydroxylase system protein, YqeB family. (272 aa) |
| | ADL11991.1 | COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (875 aa) |
