STRINGSTRING
ADL12774.1 ADL12774.1 ADL12754.1 ADL12754.1 ADL12750.1 ADL12750.1 ADL12739.1 ADL12739.1 ADL12731.1 ADL12731.1 hisC-2 hisC-2 ADL12717.1 ADL12717.1 ADL12716.1 ADL12716.1 ADL12703.1 ADL12703.1 metXA metXA ADL12598.1 ADL12598.1 thrB thrB ADL12297.1 ADL12297.1 ADL12298.1 ADL12298.1 cobT cobT cbiM cbiM cbiN cbiN ADL12316.1 ADL12316.1 ADL12330.1 ADL12330.1 ADL12337.1 ADL12337.1 ADL12365.1 ADL12365.1 cbiD cbiD ADL12367.1 ADL12367.1 ADL12368.1 ADL12368.1 ADL12369.1 ADL12369.1 ADL12370.1 ADL12370.1 ADL12371.1 ADL12371.1 ADL12372.1 ADL12372.1 ADL12373.1 ADL12373.1 ADL12374.1 ADL12374.1 cobQ cobQ cobQ-2 cobQ-2 cobD cobD cbiA cbiA ADL12379.1 ADL12379.1 cobS cobS ADL12382.1 ADL12382.1 proC proC ADL12416.1 ADL12416.1 carA carA carB carB ADL12446.1 ADL12446.1 panB-2 panB-2 ADL12457.1 ADL12457.1 ADL12461.1 ADL12461.1 ADL12462.1 ADL12462.1 ADL12475.1 ADL12475.1 ADL12478.1 ADL12478.1 ADL12484.1 ADL12484.1 ADL12538.1 ADL12538.1 plsX plsX fabH fabH ADL12542.1 ADL12542.1 acpP acpP ADL12546.1 ADL12546.1 ADL12553.1 ADL12553.1 hisC hisC ADL12555.1 ADL12555.1 ADL12556.1 ADL12556.1 aroA aroA ADL12582.1 ADL12582.1 ADL12589.1 ADL12589.1 ADL12590.1 ADL12590.1 ilvE ilvE ADL12595.1 ADL12595.1 ADL12596.1 ADL12596.1 argD argD ilvD ilvD ADL11756.1 ADL11756.1 ADL11757.1 ADL11757.1 ilvC ilvC ADL11579.1 ADL11579.1 leuA leuA leuC leuC leuD leuD ADL11762.1 ADL11762.1 ADL11763.1 ADL11763.1 ADL11847.1 ADL11847.1 ADL11850.1 ADL11850.1 tpiA tpiA ADL11878.1 ADL11878.1 mgsA mgsA selD selD ADL11904.1 ADL11904.1 ADL11906.1 ADL11906.1 ADL11907.1 ADL11907.1 ADL11918.1 ADL11918.1 ADL11991.1 ADL11991.1 ADL12051.1 ADL12051.1 ADL12052.1 ADL12052.1 mqnE mqnE mqnA mqnA mqnC mqnC ADL12060.1 ADL12060.1 menG menG proB proB proA proA ADL12178.1 ADL12178.1 ADL12179.1 ADL12179.1 ADL12181.1 ADL12181.1 ADL12214.1 ADL12214.1 ADL12227.1 ADL12227.1 pheA pheA queA queA tgt tgt ADL12254.1 ADL12254.1 apt apt ADL12267.1 ADL12267.1 serS serS ADL11607.1 ADL11607.1 ADL11614.1 ADL11614.1 ADL11661.1 ADL11661.1 panB panB panC panC panD panD ADL11691.1 ADL11691.1 purC purC ilvE-2 ilvE-2 ADL13777.1 ADL13777.1 ADL13754.1 ADL13754.1 ADL13753.1 ADL13753.1 ADL13747.1 ADL13747.1 glyA glyA fabZ fabZ kdsA kdsA ADL13644.1 ADL13644.1 ADL13615.1 ADL13615.1 acpS acpS ADL13584.1 ADL13584.1 ADL13577.1 ADL13577.1 ADL13543.1 ADL13543.1 ADL13538.1 ADL13538.1 thiE-2 thiE-2 thiM thiM thiC thiC ADL13532.1 ADL13532.1 ADL13530.1 ADL13530.1 ADL13487.1 ADL13487.1 ADL13460.1 ADL13460.1 ADL13435.1 ADL13435.1 panB-3 panB-3 ilvD-2 ilvD-2 ADL13407.1 ADL13407.1 bioB bioB bioD bioD bioA bioA ADL13403.1 ADL13403.1 ADL13383.1 ADL13383.1 ADL13374.1 ADL13374.1 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA accD accD accA accA dapF dapF ADL13361.1 ADL13361.1 ADL13346.1 ADL13346.1 ADL13339.1 ADL13339.1 ADL13338.1 ADL13338.1 ADL13332.1 ADL13332.1 ADL13331.1 ADL13331.1 ADL13328.1 ADL13328.1 pgi pgi ADL13288.1 ADL13288.1 ADL13287.1 ADL13287.1 ADL13286.1 ADL13286.1 aroE aroE aroC aroC aroK aroK aroB aroB aroQ aroQ ADL13248.1 ADL13248.1 folD folD dxs dxs argR argR ADL13230.1 ADL13230.1 lysA lysA ADL13114.1 ADL13114.1 ADL13099.1 ADL13099.1 dapB dapB asd asd ADL13082.1 ADL13082.1 dapA dapA thiE thiE ADL13078.1 ADL13078.1 thiG thiG ADL13076.1 ADL13076.1 argC argC argJ argJ argB argB carA-2 carA-2 carB-2 carB-2 ADL13039.1 ADL13039.1 argG argG argH argH pdxS pdxS pdxT pdxT fabH-2 fabH-2 hisS-2 hisS-2 hisG hisG hisD hisD hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI ADL12941.1 ADL12941.1 ADL12940.1 ADL12940.1 ribBA ribBA ribH ribH ADL12937.1 ADL12937.1 queC queC ADL12920.1 ADL12920.1 queE queE ADL12916.1 ADL12916.1 ADL12905.1 ADL12905.1 ADL12873.1 ADL12873.1 ADL12872.1 ADL12872.1 ADL12856.1 ADL12856.1 ADL12855.1 ADL12855.1 ADL12849.1 ADL12849.1 ADL12815.1 ADL12815.1 ADL12812.1 ADL12812.1 thiI thiI ADL12793.1 ADL12793.1 ADL12785.1 ADL12785.1
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ADL12774.1Orn/DAP/Arg decarboxylase 2; COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR009006:IPR000183:IPR002986; KEGG: drm:Dred_3249 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2; SPTR: A4J9J6 Diaminopimelate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase. (412 aa)
ADL12754.1COGs: COG1600 Uncharacterized Fe-S protein; KEGG: dau:Daud_0137 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: B1I0Y2 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (253 aa)
ADL12750.1Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197:IPR010722:IPR013785; KEGG: tte:TTE1568 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Q8R9N8 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (499 aa)
ADL12739.1COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
ADL12731.1COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: nth:Nther_1932 thiamine pyrophosphate protein TPP binding domain protein; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B2A6H0 Thiamine pyrophosphate protein TPP binding domain protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (541 aa)
hisC-2COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR005861:IPR001917:IPR015424:IPR004839:IPR 015421; KEGG: nth:Nther_1931 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: B2A6G9 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa)
ADL12717.1COGs: COG1760 L-serine deaminase; InterPro IPR004643:IPR005131:IPR002912; KEGG: cpf:CPF_2959 L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein; PRIAM: L-serine ammonia-lyase; SPTR: Q8XH62 Probable L-serine dehydratase beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: ACT domain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit. (223 aa)
ADL12716.1COGs: COG1760 L-serine deaminase; InterPro IPR004642:IPR005130; KEGG: amt:Amet_2318 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; PRIAM: L-serine ammonia-lyase; SPTR: A6TQK7 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: Serine dehydratase alpha chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (292 aa)
ADL12703.1COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR006282:IPR007371:IPR007373; KEGG: csc:Csac_2348 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; SPTR: A4XLZ1 Thiamine pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase. (216 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (378 aa)
ADL12598.1Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR000489:IPR011005; KEGG: drm:Dred_2207 homocysteine S-methyltransferase; PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; SPTR: A4J6L9 Methionine synthase (B12-dependent); PFAM: Pterin binding enzyme; Homocysteine S-methyltransferase. (562 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (299 aa)
ADL12297.1Hydroxymethylpyrimidine synthase; COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: drm:Dred_2890 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: A4J8J1 Thiamine biosynthesis protein thiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC. (426 aa)
ADL12298.1Hydroxymethylpyrimidine synthase; COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: hmo:HM1_2074 thiamine biosynthesis protein, ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: B0TGD5 Thiamine biosynthesis protein, thic; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC. (425 aa)
cobTNicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (350 aa)
cbiMCobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (251 aa)
cbiNCobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (97 aa)
ADL12316.1Cobalamin (vitamin B12) biosynthesis CbiM protein; COGs: COG0310 ABC-type Co2+ transport system permease component; InterPro IPR002751; KEGG: dol:Dole_2022 cobalamin (vitamin B12) biosynthesis CbiM protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; SPTR: A8ZTE3 Cobalamin (Vitamin B12) biosynthesis CbiM protein; PFAM: Cobalt uptake substrate-specific transmembrane region; TIGRFAM: cobalamin biosynthesis protein CbiM. (212 aa)
ADL12330.1Cobalamin (vitamin B12) biosynthesis CbiM protein; COGs: COG0310 ABC-type Co2+ transport system permease component; InterPro IPR002751; KEGG: dol:Dole_2022 cobalamin (vitamin B12) biosynthesis CbiM protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; SPTR: A8ZTE3 Cobalamin (Vitamin B12) biosynthesis CbiM protein; PFAM: Cobalt uptake substrate-specific transmembrane region; TIGRFAM: cobalamin biosynthesis protein CbiM. (202 aa)
ADL12337.1Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterProIPR017439:IPR001412:IPR002933:IPR011650:IPR 010168; KEGG: dth:DICTH_1768 thermostable carboxypeptidase 1; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: C4CJY7 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (393 aa)
ADL12365.1precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: cby:CLM_1073 precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C1FVC4 Precorrin-8X methylmutase; PFAM: Precorrin-8X methylmutase. (205 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (376 aa)
ADL12367.1Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COGs: COG2241 Precorrin-6B methylase 1; InterPro IPR014777:IPR000878:IPR012818; KEGG: lba:Lebu_0508 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: C7NEQ8 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), [...] (208 aa)
ADL12368.1COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR014008; KEGG: dae:Dtox_1292 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; SPTR: C6Q7R1 Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Met-10+ like-protein; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit. (196 aa)
ADL12369.1COGs: COG2243 Precorrin-2 methylase; InterPro IPR012382:IPR014777:IPR000878:IPR006364; KEGG: dae:Dtox_1293 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Cobalt-factor II C(20)-methyltransferase; SPTR: C1TH33 Precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. (237 aa)
ADL12370.1COGs: COG2875 Precorrin-4 methylase; InterProIPR003043:IPR014777:IPR014776:IPR000878:IPR 006362; KEGG: amt:Amet_0074 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: A6TJE9 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. (254 aa)
ADL12371.1COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: drm:Dred_2710 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: A1HPX3 Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. (353 aa)
ADL12372.1COGs: COG1010 Precorrin-3B methylase; InterPro IPR014777:IPR000878:IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Q6ARS2 Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. (273 aa)
ADL12373.1COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: dae:Dtox_1297 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: C6PHW4 Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. (252 aa)
ADL12374.1Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: drm:Dred_1910 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: A4J5S8 Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. (207 aa)
cobQAdenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (505 aa)
cobQ-2Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (506 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa)
cbiACobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (462 aa)
ADL12379.1Cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: hmo:HM1_1898 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: B0TFD9 ATP:corrinoid adenosyltransferase btur/cobo/cobp; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. (199 aa)
cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (251 aa)
ADL12382.1L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR004838:IPR001176:IPR015421:IPR015422:IPR 004839:IPR015424:IPR005860; KEGG: dae:Dtox_3089 L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: C1TJJ7 L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. (368 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa)
ADL12416.1MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR001317:IPR011702:IPR006220:IPR002474:IPR 000991:IPR017926:IPR006274; KEGG: drm:Dred_1683 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: A4J557 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (360 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005479:IPR005483:IPR013817:IPR013816:IPR 005481:IPR005480:IPR011607:IPR011761:IPR016185:IPR006275; KEGG: dae:Dtox_2352 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: C1T9B9 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase [...] (1070 aa)
ADL12446.1Conserved hypothetical protein; COGs: COG1600 Uncharacterized Fe-S protein; KEGG: dol:Dole_1382 hypothetical protein; SPTR: A8ZYT1 Putative uncharacterized protein. (271 aa)
panB-2Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (283 aa)
ADL12457.1KEGG: ter:Tery_3123 hypothetical protein; SPTR: Q10ZR9 Putative uncharacterized protein; PFAM: Asp/Glu/Hydantoin racemase. (263 aa)
ADL12461.1Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
ADL12462.1KEGG: ckr:CKR_1801 hypothetical protein; SPTR: B9E2X7 Putative uncharacterized protein; PFAM: Asp/Glu/Hydantoin racemase. (259 aa)
ADL12475.1D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR016040:IPR006139; KEGG: mka:MK0297 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Q8TYK0 Predicted dehydrogenase related to phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (318 aa)
ADL12478.1Creatininase; COGs: COG1402 Uncharacterized protein putative amidase; InterPro IPR003785; KEGG: tma:TM0413 creatinine amidohydrolase, putative; PFAM: Creatininase; SPTR: A8RKI8 Putative uncharacterized protein; PFAM: Creatinine amidohydrolase. (280 aa)
ADL12484.1COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
ADL12538.1InterPro IPR017275; KEGG: tte:TTE1477 fatty acid biosynthesis transcriptional regulator; SPTR: B7RAH2 Putative uncharacterized protein; PFAM: MaoC like domain. (198 aa)
plsXPhosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (335 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa)
ADL12542.1COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterProIPR004410:IPR016035:IPR016036:IPR014043:IPR 001227; KEGG: tte:TTE1473 acyl-carrier-protein S-malonyltransferase; PFAM: Acyl transferase; SPTR: Q8R9V9 (Acyl-carrier-protein) S-malonyltransferase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase. (310 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa)
ADL12546.13-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
ADL12553.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (122 aa)
hisCCOGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR005861:IPR015424:IPR004839:IPR001176:IPR 015421; KEGG: mta:Moth_0515 histidinol phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Q2RL44 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
ADL12555.1COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: tpd:Teth39_0984 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: C6Q6Z9 Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa)
ADL12556.1COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099:IPR016040:IPR002912; KEGG: hmo:HM1_1926 prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydrogenase; SPTR: B0TFQ3 Prephenate dehydrogenase, putative; PFAM: Prephenate dehydrogenase; ACT domain. (368 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
ADL12582.1COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005:IPR002856; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
ADL12589.13-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III; InterPro IPR016039:IPR013751; KEGG: nth:Nther_0475 betaine reductase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; SPTR: B2A5X8 Betaine reductase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (512 aa)
ADL12590.1COGs: COG0416 Fatty acid/phospholipid biosynthesis enzyme; InterPro IPR012116:IPR003664; KEGG: nth:Nther_0476 glycine reductase; PFAM: fatty acid synthesis plsX protein; SPTR: B2A5X9 Glycine reductase; PFAM: Fatty acid synthesis protein. (386 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (291 aa)
ADL12595.1COGs: COG0460 Homoserine dehydrogenase; InterProIPR016204:IPR019811:IPR016040:IPR005106:IPR 001342:IPR002912; KEGG: dae:Dtox_2114 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; PRIAM: Homoserine dehydrogenase; SPTR: C1TG46 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (429 aa)
ADL12596.1COGs: COG0527 Aspartokinase; InterProIPR005260:IPR001341:IPR018042:IPR001048:IPR 002912; KEGG: drm:Dred_1167 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: A4J3P8 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (413 aa)
argDCOGs: COG4992 Ornithine/acetylornithine aminotransferase; InterProIPR004636:IPR015422:IPR015421:IPR005814:IPR 015424; KEGG: hor:Hore_02850 acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: B8D1G9 Acetylornithine and succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (396 aa)
ilvDCOGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR020558:IPR000581:IPR004404; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C7HB79 Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
ADL11756.1Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-t [...] (578 aa)
ADL11757.1COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8TJJ3 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (160 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
ADL11579.1COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterProIPR006139:IPR006140:IPR002912:IPR016040:IPR 006236; KEGG: hor:Hore_11540 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: B8CX87 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic [...] (527 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
ADL11762.1COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818:IPR001804; KEGG: hor:Hore_10890 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: B8CX24 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase. (348 aa)
ADL11763.1(R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR002034:IPR000891:IPR013709:IPR013785:IPR 005675; KEGG: pfu:PF0941 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: Q8U298 Leua homolog alpha-isopropylmalate synthase related; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to [...] (525 aa)
ADL11847.1COGs: COG0561 hydrolase of the HAD superfamily; InterPro IPR013200:IPR000150:IPR006379; KEGG: drm:Dred_3056 Cof-like hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; SPTR: A4J905 Cof-like hydrolase; TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; HAD-superfamily hydrolase, subfamily IIB. (266 aa)
ADL11850.1LmbE family protein; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: drm:Dred_2324 LmbE family protein; PFAM: LmbE family protein; SPTR: C0GG03 LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase. (236 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
ADL11878.1Ferredoxin; COGs: COG3894 Uncharacterized metal-binding protein; InterPro IPR012675:IPR001041; KEGG: dhd:Dhaf_3310 ferredoxin; PFAM: ferredoxin; SPTR: C6PA24 Vitamin B12 dependent methionine synthase activation region; PFAM: 2Fe-2S iron-sulfur cluster binding domain. (611 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (126 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (317 aa)
ADL11904.1COGs: COG0502 Biotin synthase; InterProIPR013785:IPR002114:IPR006638:IPR005244:IPR 007197; KEGG: dae:Dtox_0028 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C1TAS3 Biotin synthase; PFAM: Radical SAM superfamily. (368 aa)
ADL11906.1Protein of unknown function DUF201; COGs: COG0439 Biotin carboxylase; InterProIPR013817:IPR011761:IPR016185:IPR016040:IPR 006076:IPR003806; KEGG: dhd:Dhaf_4856 protein of unknown function DUF201; PFAM: protein of unknown function DUF201; FAD dependent oxidoreductase; SPTR: Q24MJ6 Putative uncharacterized protein; PFAM: Pyridine nucleotide-disulphide oxidoreductase; ATP-grasp domain. (390 aa)
ADL11907.1InterPro IPR016040; KEGG: dae:Dtox_0030 hypothetical protein; SPTR: C1TAS5 Putative uncharacterized protein. (268 aa)
ADL11918.1Thioesterase superfamily protein; COGs: COG0824 thioesterase; InterPro IPR006684:IPR006683; KEGG: tte:TTE1814 thioesterase; PFAM: thioesterase superfamily protein; SPTR: C6PDX6 Thioesterase superfamily protein; PFAM: Thioesterase superfamily; TIGRFAM: conserved hypothetical protein TIGR00051; tol-pal system-associated acyl-CoA thioesterase. (141 aa)
ADL11991.1COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
ADL12051.1COGs: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylase; InterPro IPR002830; KEGG: hor:Hore_14820 UbiD family decarboxylase; PFAM: Carboxylyase-related protein; SPTR: B8CY62 UbiD family decarboxylase; TIGRFAM: UbiD family decarboxylase; PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylases; Belongs to the UbiD family. (483 aa)
ADL12052.1COGs: COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; InterPro IPR006371:IPR000537; KEGG: dae:Dtox_1642 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; SPTR: A5D2A3 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase. (281 aa)
mqnERadical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (365 aa)
mqnAProtein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (282 aa)
mqnCRadical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (359 aa)
ADL12060.1Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR001261:IPR011650:IPR002933; KEGG: sth:STH1479 putative peptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Q67PC9 Putative peptidase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (379 aa)
menGUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (234 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
ADL12178.1Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8CX18 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TP [...] (577 aa)
ADL12179.1COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: mma:MM_0669 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Q8PZ25 Acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (159 aa)
ADL12181.1COGs: COG0095 Lipoate-protein ligase A; InterPro IPR005107:IPR004143:IPR019491:IPR004562; KEGG: hor:Hore_05080 lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase; Lipoate protein ligase-like; PRIAM: Lipoate--protein ligase; SPTR: B8D239 Lipoate-protein ligase; TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: Bacterial lipoate protein ligase C-terminus; Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase. (345 aa)
ADL12214.1LmbE family protein; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: ate:Athe_0312 LmbE family protein; PFAM: LmbE family protein; SPTR: B9MMZ6 LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase. (440 aa)
ADL12227.1Fructose-1,6-bisphosphatase, class II; COGs: COG1494 Fructose-1 6-bisphosphatase/sedoheptulose 1 7-bisphosphatase and related protein; InterPro IPR004464; KEGG: nth:Nther_2876 fructose 1,6-bisphosphatase II; PFAM: GlpX family protein; PRIAM: Fructose-bisphosphatase; SPTR: B2A3J4 Fructose-1,6-bisphosphatase, class II; TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: Bacterial fructose-1,6-bisphosphatase, glpX-encoded; TIGRFAM: fructose-1,6-bisphosphatase, class II. (327 aa)
pheACOGs: COG0077 Prephenate dehydratase; InterPro IPR018528:IPR001086:IPR002912; KEGG: msi:Msm_1052 prephenate dehydratase, PheA; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: A5UM29 Prephenate dehydratase, PheA; PFAM: Prephenate dehydratase; ACT domain. (277 aa)
queAS-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa)
tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (371 aa)
ADL12254.1ABC-1 domain protein; COGs: COG0661 unusual protein kinase; InterPro IPR004147:IPR002575:IPR011009; KEGG: hor:Hore_12230 2-octaprenylphenol hydroxylase; PFAM: ABC-1 domain protein; aminoglycoside phosphotransferase; SPTR: B8CXF4 2-octaprenylphenol hydroxylase; PFAM: Phosphotransferase enzyme family; ABC1 family. (559 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
ADL12267.1Protein of unknown function DUF161; COGs: COG2364 membrane protein; InterPro IPR003740; KEGG: bbe:BBR47_28180 hypothetical protein; PFAM: protein of unknown function DUF161; SPTR: C0ZDD6 Conserved hypothetical membrane protein; PFAM: Uncharacterized BCR, YitT family COG1284. (204 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
ADL11607.1InterPro IPR007197; KEGG: drm:Dred_1747 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: A4J5B9 Radical SAM domain protein; PFAM: Radical SAM superfamily. (201 aa)
ADL11614.1Sulfide dehydrogenase (flavoprotein) subunit SudA; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR012285:IPR009051:IPR006004; KEGG: dhd:Dhaf_3501 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: B8FQ58 Glutamate synthase (NADPH), homotetrameric; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (458 aa)
ADL11661.1COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836:IPR005904; KEGG: hor:Hore_00570 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: B8D064 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (117 aa)
ADL11691.1COGs: COG1045 Serine acetyltransferase; InterPro IPR001451:IPR011004:IPR005881; KEGG: chy:CHY_2339 serine acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: C6PB49 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase. (223 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR018236:IPR001636:IPR013816; KEGG: csc:Csac_1999 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: C6PBZ2 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (236 aa)
ilvE-2Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (283 aa)
ADL13777.1C_GCAxxG_C_C family protein; InterPro IPR010181; KEGG: cpy:Cphy_1476 C_GCAxxG_C_C family protein; PFAM: C_GCAxxG_C_C family protein; SPTR: A9KPV1 C_GCAxxG_C_C family protein; TIGRFAM: C_GCAxxG_C_C family protein; PFAM: Putative redox-active protein (C_GCAxxG_C_C); TIGRFAM: C_GCAxxG_C_C family probable redox protein. (153 aa)
ADL13754.13-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III; InterPro IPR013751:IPR016039; KEGG: nth:Nther_0475 betaine reductase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; SPTR: B2A5X8 Betaine reductase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (512 aa)
ADL13753.1COGs: COG0416 Fatty acid/phospholipid biosynthesis enzyme; InterPro IPR012116:IPR003664; KEGG: nth:Nther_0476 glycine reductase; PFAM: fatty acid synthesis plsX protein; SPTR: B2A5X9 Glycine reductase; PFAM: Fatty acid synthesis protein. (386 aa)
ADL13747.1Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: hor:Hore_18400 beta-lactamase domain protein; SPTR: B8CZ70 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (274 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
fabZ3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006218:IPR013785:IPR006269; KEGG: hor:Hore_18920 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; SPTR: B8CZC1 2-dehydro-3-deoxyphosphooctonate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase. (275 aa)
ADL13644.1Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterProIPR017476:IPR001732:IPR014026:IPR014027:IPR 016040:IPR008927; KEGG: bld:BLi03804 TuaD; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: Q65E94 TuaD; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP bindin [...] (436 aa)
ADL13615.1Polysaccharide biosynthesis protein; COGs: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; InterPro IPR002797; KEGG: hma:pNG7214 export protein; PFAM: polysaccharide biosynthesis protein; SPTR: Q5V6D5 Probable export protein; PFAM: Polysaccharide biosynthesis protein. (495 aa)
acpSHolo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (124 aa)
ADL13584.1Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR010168:IPR002933:IPR011650:IPR017439; KEGG: ava:Ava_2218 peptidase M20D, amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: A1HTZ9 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (399 aa)
ADL13577.1Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR000385:IPR007197:IPR001478:IPR006638; KEGG: dae:Dtox_3511 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C1TBZ1 Predicted Fe-S oxidoreductase; PFAM: Radical SAM superfamily; Protein of unknown function (DUF512). (450 aa)
ADL13543.1Isocitrate dehydrogenase, NAD-dependent; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR004434:IPR019818:IPR001804; KEGG: hor:Hore_08060 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: C6PZB2 Isocitrate dehydrogenase (NAD(+)); TIGRFAM: isocitrate dehydrogenase, NAD-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokar [...] (331 aa)
ADL13538.1Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399:IPR013749; KEGG: mta:Moth_0867 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: Q2RK55 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase. (263 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (213 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (261 aa)
thiCHydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (427 aa)
ADL13532.1Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR013785:IPR005244:IPR006638; KEGG: dps:DP2376 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C4BY12 Biotin synthase-like enzyme; PFAM: Radical SAM superfamily. (377 aa)
ADL13530.1Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: dae:Dtox_2552 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: C1TEC1 Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain. (266 aa)
ADL13487.1COGs: COG0069 Glutamate synthase domain 2; InterPro IPR002932:IPR013785; KEGG: hor:Hore_17300 glutamate synthase (NADPH) large subunit; PFAM: ferredoxin-dependent glutamate synthase; SPTR: B8CYW0 Glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (471 aa)
ADL13460.1COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: hor:Hore_23060 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: B8D199 Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases. (308 aa)
ADL13435.1Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR010168:IPR002933:IPR011650:IPR017439; KEGG: pho:PH1043 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: O58754 387aa long hypothetical amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (391 aa)
panB-3Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (283 aa)
ilvD-2COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404:IPR020558:IPR000581; KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C5EPY2 Dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (560 aa)
ADL13407.1Iron-sulfur cluster binding protein; COGs: COG1600 Uncharacterized Fe-S protein; InterProIPR004453:IPR017900:IPR017896:IPR013542:IPR 001450:IPR004155:IPR009051:IPR016024:IPR011989; KEGG: gwc:GWCH70_0503 iron-sulfur cluster binding protein; PFAM: domain of unknown function DUF1730; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PBS lyase HEAT domain protein repeat-containing protein; SPTR: C5D5W5 Iron-sulfur cluster binding protein; TIGRFAM: iron-sulfur cluster binding protein; PFAM: Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative. (372 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (326 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (240 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoateaminotr ansferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (451 aa)
ADL13403.1COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: hmo:HM1_1923 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: B0TFQ1 Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (272 aa)
ADL13383.1COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR010140:IPR004013:IPR016195:IPR003141; KEGG: hor:Hore_11520 histidinol-phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: B8CX85 Histidinol-phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (253 aa)
ADL13374.1COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR013785; KEGG: hmo:HM1_1923 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA; SPTR: B0TFQ1 Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (271 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
trpCCOGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798:IPR011060:IPR013785; KEGG: amt:Amet_1080 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: A6TM74 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa)
trpFCOGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240:IPR011060:IPR013785; KEGG: gur:Gura_1736 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: C6MQI3 Phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (209 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (302 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa)
ADL13361.1LL-diaminopimelate aminotransferase apoenzyme; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838:IPR004839:IPR015424:IPR015421; KEGG: ate:Athe_0546 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: C6J3D0 Aminotransferase class I and II; PFAM: Aminotransferase class I and II. (413 aa)
ADL13346.1Di-trans-poly-cis-decaprenylcistransferase; COGs: COG0020 Undecaprenyl pyrophosphate synthase; InterPro IPR001441; KEGG: hor:Hore_14480 di-trans-poly-cis-decaprenylcistransferase; PFAM: Di-trans-poly-cis-decaprenylcistransferase; SPTR: B8CY28 Di-trans-poly-cis-decaprenylcistransferase; PFAM: Putative undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase. (215 aa)
ADL13339.1COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR016040:IPR006139:IPR006140; KEGG: cno:NT01CX_0601 D-isomer specific 2-hydroxyacid dehydrogenases; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; PRIAM: Phosphoglycerate dehydrogenase; SPTR: C5VNM2 Putative glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (317 aa)
ADL13338.1COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterProIPR017932:IPR006426:IPR014729:IPR000583:IPR 001962; KEGG: mta:Moth_1299 asparagine synthase, glutamine-hydrolyzing; PFAM: asparagine synthase; glutamine amidotransferase class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: Q2RIX6 Asparagine synthase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (613 aa)
ADL13332.1Glutamate synthase (NADPH) GltB1 subunit; COGs: COG0067 Glutamate synthase domain 1; InterPro IPR017932:IPR012375:IPR000583; KEGG: hor:Hore_16310 glutamate synthase (NADPH) GltB1 subunit; PFAM: glutamine amidotransferase class-II; SPTR: B8CYL1 Glutamate synthase (NADPH) GltB1 subunit; PFAM: Glutamine amidotransferases class-II. (365 aa)
ADL13331.1Glutamate synthase (NADPH) GltB2 subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017896:IPR013785:IPR001450:IPR002932:IPR 017900; KEGG: hor:Hore_16300 glutamate synthase (NADPH); PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: Glutamate synthase (NADPH); SPTR: B8CYL0 Glutamate synthase (NADPH); PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (500 aa)
ADL13328.1Glutamate synthase (NADPH) GltB3 subunit; COGs: COG0070 Glutamate synthase domain 3; InterPro IPR012061:IPR002489; KEGG: hor:Hore_16290 glutamate synthase (NADPH) GltB3 subunit; PFAM: glutamate synthase alpha subunit domain protein; SPTR: B8CYK9 Glutamate synthase (NADPH) GltB3 subunit; PFAM: GXGXG motif. (245 aa)
pgiCOGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR001672:IPR018189; KEGG: hor:Hore_19060 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); SPTR: B8CZD5 Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family. (473 aa)
ADL13288.1COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR006390:IPR011005; KEGG: cth:Cthe_2581 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: C7HBS7 Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. (399 aa)
ADL13287.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa)
ADL13286.12-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: bay:RBAM_000900 hypothetical protein; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: A7Z0K2 FolK; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (164 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (400 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (141 aa)
ADL13248.1Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
folD5,10-methylenetetrahydrofolate dehydrogenase (NADP+) methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (630 aa)
argRTranscriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (150 aa)
ADL13230.1Thiamin pyrophosphokinase catalytic region; COGs: COG4825 Uncharacterized membrane-anchored protein; InterPro IPR007371; KEGG: tte:TTE1305 hypothetical protein; PFAM: Thiamin pyrophosphokinase catalytic region; SPTR: C6P837 Thiamin pyrophosphokinase catalytic region; PFAM: Thiamine pyrophosphokinase C terminal; Thiamin pyrophosphokinase, catalytic domain. (372 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (437 aa)
ADL13114.1Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (241 aa)
ADL13099.1Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterPro IPR002606:IPR014729:IPR015865:IPR015864; KEGG: hor:Hore_07880 FMN adenylyltransferase;riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: B8CW76 FMN adenylyltransferase;riboflavin kinase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (307 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (265 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
ADL13082.1COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048:IPR018042; KEGG: hor:Hore_08680 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: B8CWF5 Aspartokinase; TIGRFAM: aspartate kinase; PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (407 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
ADL13078.1Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR012726:IPR013785:IPR007197:IPR010722; KEGG: mta:Moth_1664 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Q2RHX3 Thiazole biosynthesis ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (366 aa)
thiGThiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
ADL13076.1Thiamine biosynthesis protein ThiS; InterPro IPR010035:IPR012675:IPR003749:IPR016155; KEGG: dae:Dtox_1679 thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; SPTR: C1TJF7 Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (66 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (287 aa)
carA-2COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR002474:IPR006274:IPR017926:IPR000991:IPR 001317:IPR011702:IPR006220; KEGG: amt:Amet_4211 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: A6TVS3 Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (359 aa)
carB-2COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR016185:IPR005480:IPR006275:IPR011761:IPR 005481:IPR005479:IPR011607:IPR013817:IPR013816:IPR005483; KEGG: cth:Cthe_1868 carbamoyl-phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: A3DGL0 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L [...] (1067 aa)
ADL13039.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa)
argGCOGs: COG0137 Argininosuccinate synthase; InterPro IPR001518:IPR014729:IPR018223; KEGG: hor:Hore_02900 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: B8D1H4 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa)
argHCOGs: COG0165 Argininosuccinate lyase; InterProIPR008948:IPR009049:IPR000362:IPR020557:IPR 003031; KEGG: pca:Pcar_2418 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Q3A1V0 Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (456 aa)
pdxSPyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa)
pdxTPyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (192 aa)
fabH-23-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (331 aa)
hisS-2histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (420 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (218 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisBCOGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR020568:IPR000807:IPR020565; KEGG: cth:Cthe_2884 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: C7HI03 Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (195 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR011060:IPR006063:IPR006062:IPR013785; KEGG: syp:SYNPCC7002_A1890 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: A3ISI1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methyli [...] (243 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisICOGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496; KEGG: dae:Dtox_0758 phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: C1TDK3 Phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (240 aa)
ADL12941.1Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (371 aa)
ADL12940.1COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR017938:IPR001783; KEGG: swo:Swol_1221 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: C6Q2S9 Riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (217 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (404 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa)
ADL12937.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (375 aa)
queCpreQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (223 aa)
ADL12920.1preQ(0) biosynthesis protein QueD; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: apa:APP7_1154 putative 6-pyruvoyl tetrahydrobiopterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: C7IE00 Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (165 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (240 aa)
ADL12916.1Protein of unknown function DUF161; COGs: COG2364 membrane protein; InterPro IPR003740; KEGG: bha:BH1258 hypothetical protein; PFAM: protein of unknown function DUF161; SPTR: Q9KDF5 BH1258 protein; PFAM: Uncharacterized BCR, YitT family COG1284. (196 aa)
ADL12905.1Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR011650:IPR010168:IPR002933:IPR017439; KEGG: ton:TON_0348 bifunctional carboxypeptidase/aminoacylase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: C4CJY7 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (393 aa)
ADL12873.1COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR015424:IPR005814:IPR015421:IPR010916; KEGG: tth:TTC0553 ornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: A1HTU7 Acetylornithine and succinylornithine aminotransferases; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
ADL12872.1Cyclase/dehydrase; InterPro IPR005031; KEGG: hmo:HM1_1942 streptomyces cyclase/dehydrase, putative; PFAM: cyclase/dehydrase; SPTR: B0TFS0 Streptomyces cyclase/dehydrase, putative; PFAM: Polyketide cyclase / dehydrase and lipid transport. (144 aa)
ADL12856.1Phosphosulfolactate synthase; COGs: COG1809 conserved hypothetical protein; InterPro IPR003830:IPR013785; KEGG: drm:Dred_1677 phosphosulfolactate synthase; PFAM: (2R)-phospho-3-sulfolactate synthase ComA; PRIAM: Phosphosulfolactate synthase; SPTR: A4J551 Phosphosulfolactate synthase; PFAM: (2R)-phospho-3-sulfolactate synthase (ComA). (279 aa)
ADL12855.12-phosphosulfolactate phosphatase; COGs: COG2045 Phosphosulfolactate phosphohydrolase; InterPro IPR005238; KEGG: cbe:Cbei_0040 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulfolactate phosphatase; PRIAM: 2-phosphosulfolactate phosphatase; SPTR: A6LPF0 Probable 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (237 aa)
ADL12849.1InterPro IPR004223; KEGG: tpd:Teth39_0998 vitamin B12 dependent methionine synthase, activation region; PFAM: Vitamin B12 dependent methionine synthase activation region; SPTR: B0K940 Vitamin B12 dependent methionine synthase, activation region; PFAM: Vitamin B12 dependent methionine synthase, activation domain. (224 aa)
ADL12815.1Ferredoxin; COGs: COG3894 Uncharacterized metal-binding protein; InterPro IPR001041:IPR012675; KEGG: dhd:Dhaf_2795 ferredoxin; PFAM: ferredoxin; SPTR: C0GF45 Ferredoxin; PFAM: 2Fe-2S iron-sulfur cluster binding domain. (644 aa)
ADL12812.1Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR011005:IPR000489; KEGG: chy:CHY_1227 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Q3ACR9 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; PFAM: Pterin binding enzyme. (262 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (391 aa)
ADL12793.1InterPro IPR016181:IPR000182; KEGG: mbu:Mbur_0273 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Q12Z48 Acetyltransferase (GNAT) family protein; PFAM: Acetyltransferase (GNAT) family. (292 aa)
ADL12785.1COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR011005:IPR000489; KEGG: mta:Moth_2115 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase; SPTR: Q2RGN2 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: Pterin binding enzyme. (265 aa)
Your Current Organism:
Acetohalobium arabaticum
NCBI taxonomy Id: 574087
Other names: A. arabaticum DSM 5501, Acetohalobium arabaticum DSM 5501, Acetohalobium arabaticum str. DSM 5501, Acetohalobium arabaticum strain DSM 5501
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