STRINGSTRING
VS_0014 VS_0014 VS_0082 VS_0082 hslO hslO VS_0133 VS_0133 waaP waaP groS groS groL groL hfq hfq fur fur clpB clpB VS_0593 VS_0593 grpE grpE dnaK dnaK dnaJ dnaJ VS_0689 VS_0689 clpS clpS VS_1074 VS_1074 bpt bpt aat aat VS_1186 VS_1186 VS_1208 VS_1208 VS_1568 VS_1568 VS_1628 VS_1628 VS_1786 VS_1786 VS_1787 VS_1787 VS_1788 VS_1788 VS_1789 VS_1789 VS_2126 VS_2126 VS_2127 VS_2127 VS_2146 VS_2146 lon lon clpX clpX clpP clpP fur-2 fur-2 htpG htpG VS_2280 VS_2280 VS_2842 VS_2842 VS_2880 VS_2880 hslV hslV hslU hslU VS_3072 VS_3072 VS_II0148 VS_II0148 VS_II0360 VS_II0360 VS_II0558 VS_II0558 VS_II0704 VS_II0704 VS_II0764 VS_II0764 VS_II1097 VS_II1097 VS_II1339 VS_II1339
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VS_0014Small heat shock protein ibpA (16 kDa heat shock protein A); Belongs to the small heat shock protein (HSP20) family. (144 aa)
VS_0082Glutathione reductase. (455 aa)
hslO33 kDa chaperonin (Heat shock protein 33 homolog); Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (297 aa)
VS_0133Hypothetical protein; Belongs to the HSP15 family. (128 aa)
waaP3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (240 aa)
groSPutative Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
groL60 kDa chaperonin (Protein Cpn60) (groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
hfqRNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (88 aa)
furPutative zinc uptake regulation protein; Belongs to the Fur family. (151 aa)
clpBChaperone clpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
VS_0593Antioxidant, AhpC/Tsa family. (202 aa)
grpEProtein grpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (193 aa)
dnaKChaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (637 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (381 aa)
VS_0689Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (182 aa)
clpSATP-dependent Clp protease adaptor protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (106 aa)
VS_1074ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (757 aa)
bptPutative arginyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily. (239 aa)
aatLeucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (236 aa)
VS_1186Thioredoxin reductase. (319 aa)
VS_1208Hypothetical protein. (366 aa)
VS_1568Putative glutathione S-transferase. (219 aa)
VS_1628Glutathione S-transferase. (218 aa)
VS_1786Hypothetical protein. (210 aa)
VS_1787DnaK-related protein; Belongs to the heat shock protein 70 family. (659 aa)
VS_1788Putative chaperone protein dnaK (Heat shock protein 70); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (824 aa)
VS_1789DnaK-related protein (fragment). (147 aa)
VS_2126Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (185 aa)
VS_2127Alkyl hydroperoxide reductase subunit F. (530 aa)
VS_2146Putative ABC transporter; Belongs to the glutathione peroxidase family. (181 aa)
lonATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (783 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (208 aa)
fur-2Ferric uptake regulation protein; Belongs to the Fur family. (149 aa)
htpGChaperone protein htpG; Molecular chaperone. Has ATPase activity. (634 aa)
VS_2280Protein ybbN. (284 aa)
VS_2842FkpA protein. (262 aa)
VS_2880Peroxiredoxin family protein/glutaredoxin. (242 aa)
hslVATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (182 aa)
hslUATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (446 aa)
VS_3072Thioredoxin; Belongs to the thioredoxin family. (112 aa)
VS_II0148Catalase; Belongs to the catalase family. (483 aa)
VS_II0360Putative heat shock protein 70 family protein. (454 aa)
VS_II0558Peptidyl-prolyl cis-trans isomerase-related protein. (157 aa)
VS_II0704Thioredoxin 2. (144 aa)
VS_II0764Heat shock protein DnaJ. (206 aa)
VS_II1097Glutathione S-transferase; Belongs to the GST superfamily. (224 aa)
VS_II1339Putative glutathione S-transferase. (215 aa)
Your Current Organism:
Vibrio tasmaniensis
NCBI taxonomy Id: 575788
Other names: V. tasmaniensis LGP32, Vibrio lentus MEL32, Vibrio splendidus LGP32, Vibrio tasmaniensis LGP32
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