(22 nodes) Thiamine metabolism, and ThiS family network (Vibrio tasmaniensis)

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Your Input:
	rsgA	Probable GTPase engC protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (351 aa)
	VS_1876	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (131 aa)
	VS_2074	Conserved hypothetical protein. (288 aa)
	VS_2326	Transposase (orfB) of insertion sequence ISVisp4; Function of strongly homologous gene; enzyme. (268 aa)
	VS_2327	Transposase (orfA) of insertion sequence ISVisp4; Function of strongly homologous gene; enzyme. (139 aa)
	VS_2328	SAM-dependent methyltransferase. (262 aa)
	VS_2330	Soluble lytic murein transglycosylase. (523 aa)
	VS_2331	Conserved hypothetical protein. (228 aa)
	thiL	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
	VS_3093	ThiH. (375 aa)
	thiG	ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa)
	VS_3095	ThiS. (69 aa)
	VS_3096	ThiF. (260 aa)
	VS_3097	ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (430 aa)
	thiC	ThiC, thiamin biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (649 aa)
	rsgA-2	Putative GTPase (eng C); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (354 aa)
	VS_II0489	Molybdopterin biosynthesis protein moeB. (251 aa)
	thiE	Putative thiamine monophosphate syntase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (228 aa)
	thiM	Putative hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (280 aa)
	VS_II1086	Putative transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (222 aa)
	VS_II1090	Phosphomethylpyrimidine kinase. (302 aa)
	VS_II1447	Conserved hypothetical protein. (206 aa)

Your Current Organism:

Vibrio tasmaniensis

NCBI taxonomy Id: 575788
Other names: V. tasmaniensis LGP32, Vibrio lentus MEL32, Vibrio splendidus LGP32, Vibrio tasmaniensis LGP32

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
VS_1876	VS_2074	VS_1876	VS_2074	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Conserved hypothetical protein.	0.436
VS_1876	VS_2330	VS_1876	VS_2330	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Soluble lytic murein transglycosylase.	0.831
VS_1876	VS_3093	VS_1876	VS_3093	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	ThiH.	0.762
VS_1876	VS_3095	VS_1876	VS_3095	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	ThiS.	0.789
VS_1876	VS_3096	VS_1876	VS_3096	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	ThiF.	0.586
VS_1876	VS_II0489	VS_1876	VS_II0489	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Molybdopterin biosynthesis protein moeB.	0.586
VS_1876	VS_II1086	VS_1876	VS_II1086	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Putative transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.	0.668
VS_1876	VS_II1090	VS_1876	VS_II1090	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Phosphomethylpyrimidine kinase.	0.935
VS_1876	rsgA	VS_1876	VS_0254	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Probable GTPase engC protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.712
VS_1876	rsgA-2	VS_1876	VS_II0177	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Putative GTPase (eng C); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.712
VS_1876	thiC	VS_1876	VS_3098	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	ThiC, thiamin biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.	0.884
VS_1876	thiG	VS_1876	VS_3094	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.839
VS_1876	thiL	VS_1876	VS_2408	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	0.815
VS_1876	thiM	VS_1876	VS_II1085	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Putative hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.926
VS_2074	VS_1876	VS_2074	VS_1876	Conserved hypothetical protein.	Putative MutT/nudix hydrolase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.436
VS_2074	VS_3097	VS_2074	VS_3097	Conserved hypothetical protein.	ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	0.683
VS_2074	VS_II1086	VS_2074	VS_II1086	Conserved hypothetical protein.	Putative transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.	0.717
VS_2074	VS_II1090	VS_2074	VS_II1090	Conserved hypothetical protein.	Phosphomethylpyrimidine kinase.	0.714
VS_2074	rsgA	VS_2074	VS_0254	Conserved hypothetical protein.	Probable GTPase engC protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.669
VS_2074	rsgA-2	VS_2074	VS_II0177	Conserved hypothetical protein.	Putative GTPase (eng C); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.669