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VS_II0457 VS_II0457 VS_II0535 VS_II0535 VS_II0584 VS_II0584 VS_II1327 VS_II1327 VS_II1398 VS_II1398 VS_II1399 VS_II1399 fadB fadB ilvC ilvC gpsA gpsA VS_0171 VS_0171 VS_0230 VS_0230 VS_0352 VS_0352 mdh mdh pdxA pdxA leuB leuB VS_0483 VS_0483 guaB guaB VS_0684 VS_0684 fadJ fadJ pdxB pdxB VS_0958 VS_0958 VS_1024 VS_1024 VS_1071 VS_1071 maeA maeA VS_1212 VS_1212 zwf zwf VS_1306 VS_1306 VS_1609 VS_1609 VS_1835 VS_1835 hisD hisD dxr dxr VS_2413 VS_2413 VS_2640 VS_2640 VS_2893 VS_2893 VS_2896 VS_2896 VS_2957 VS_2957 murB murB aroE aroE VS_II0105 VS_II0105 VS_II0150 VS_II0150 VS_II0409 VS_II0409 tdh tdh VS_II0445 VS_II0445
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VS_II04573-hydroxy-3-methylglutaryl-coenzyme A reductase. (429 aa)
VS_II0535Iron-containing alcohol dehydrogenase. (382 aa)
VS_II0584Acetoacetyl-CoA reductase. (246 aa)
VS_II1327Putative alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (382 aa)
VS_II1398L-lactate dehydrogenase. (382 aa)
VS_II1399Fe-S oxidoreductase. (951 aa)
fadBFatty oxidation complex, alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (723 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (494 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD+); Function of homologous gene experimentally demonstrated in another organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (370 aa)
VS_0171Putative alcohol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (386 aa)
VS_0230Putative dTDP-4-dehydrorhamnose reductase (rfbD); Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (286 aa)
VS_0352Putative 2-hydroxyacid dehydrogenase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (338 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
VS_0483Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (819 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
VS_06842-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (297 aa)
fadJFatty acid oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (748 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (377 aa)
VS_0958Alcohol dehydrogenase/acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (902 aa)
VS_10243-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
VS_1071Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
maeANAD-dependent malic enzyme. (562 aa)
VS_1212Hypothetical protein. (1011 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (501 aa)
VS_13066-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa)
VS_1609Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
VS_1835Alcohol dehydrogenase IV. (430 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa)
dxrPutative 1-deoxy-D-xylulose 5-phosphate reductoisomeras; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (361 aa)
VS_2413Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (374 aa)
VS_2640D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
VS_2893Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (803 aa)
VS_2896NADP-dependent malic enzyme. (429 aa)
VS_2957Phosphoglycerate dehydrogenase. (308 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (352 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (276 aa)
VS_II0105Putative dihydrofolate reductase. (188 aa)
VS_II0150D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
VS_II04096-phosphogluconate dehydrogenase, decarboxylating 2; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (502 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (343 aa)
VS_II0445Alcohol dehydrogenase II. (382 aa)
Your Current Organism:
Vibrio tasmaniensis
NCBI taxonomy Id: 575788
Other names: V. tasmaniensis LGP32, Vibrio lentus MEL32, Vibrio splendidus LGP32, Vibrio tasmaniensis LGP32
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