STRINGSTRING
VS_1024 VS_1024 VS_1043 VS_1043 VS_1127 VS_1127 maeA maeA VS_1248 VS_1248 zwf zwf VS_1306 VS_1306 VS_1404 VS_1404 VS_1421 VS_1421 VS_1577 VS_1577 VS_1594 VS_1594 VS_1609 VS_1609 VS_1621 VS_1621 VS_1704 VS_1704 VS_1751 VS_1751 VS_1850 VS_1850 VS_1946 VS_1946 VS_2011 VS_2011 VS_2048 VS_2048 VS_2215 VS_2215 sucD sucD VS_2263 VS_2263 VS_2278 VS_2278 VS_2279 VS_2279 dxr dxr VS_2567 VS_2567 VS_2640 VS_2640 epd epd proC proC kefB kefB VS_II1501 VS_II1501 argC argC VS_2893 VS_2893 VS_2896 VS_2896 VS_2957 VS_2957 VS_3033 VS_3033 aroE aroE VS_3129 VS_3129 VS_II0078 VS_II0078 VS_II0089 VS_II0089 VS_II0126 VS_II0126 VS_II0150 VS_II0150 VS_II0250 VS_II0250 VS_II0346 VS_II0346 VS_II0391 VS_II0391 VS_II0409 VS_II0409 tdh tdh VS_II0440 VS_II0440 VS_II0556 VS_II0556 VS_II0584 VS_II0584 VS_II0732 VS_II0732 VS_II0748 VS_II0748 VS_II0752 VS_II0752 VS_II0756 VS_II0756 fabV-2 fabV-2 VS_II1120 VS_II1120 VS_II1221 VS_II1221 VS_II1272 VS_II1272 VS_II1274 VS_II1274 VS_II1277 VS_II1277 VS_II1327 VS_II1327 VS_II1453 VS_II1453 VS_II1477 VS_II1477 VS_II1462 VS_II1462 VS_0039 VS_0039 fadB fadB ilvC ilvC waaD waaD gpsA gpsA rffG rffG VS_0230 VS_0230 VS_0232 VS_0232 VS_0234 VS_0234 VS_0352 VS_0352 mdh mdh dapB dapB VS_0483 VS_0483 VS_0548 VS_0548 VS_0684 VS_0684 hemA hemA VS_0771 VS_0771 fadJ fadJ folD folD pdxB pdxB asd asd VS_0932 VS_0932 VS_0942 VS_0942 asd-2 asd-2 VS_0959 VS_0959
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VS_10243-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
VS_1043Hypothetical oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
VS_1127Potassium channel related protein. (343 aa)
maeANAD-dependent malic enzyme. (562 aa)
VS_12482-hydroxy-3-oxopropionate reductase; Function of homologous gene experimentally demonstrated in another organism; enzyme. (293 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (501 aa)
VS_13066-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa)
VS_1404Uroporphyrin-III C-methyltransferase. (313 aa)
VS_1421NAD-specific glutamate dehydrogenase. (1613 aa)
VS_1577Oxidoreductase, short-chain dehydrogenase/reductase family. (243 aa)
VS_1594Hypothetical protein. (286 aa)
VS_1609Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
VS_1621Putative C-factor. (246 aa)
VS_1704Hypothetical protein. (231 aa)
VS_1751Oxidoreductase, short chain dehydrogenase/reductase family. (238 aa)
VS_1850Putative nucleoside-diphosphate-sugar epimerase. (478 aa)
VS_1946Putative saccharopine dehydrogenase. (417 aa)
VS_2011Nucleoside-diphosphate-sugar epimerase. (284 aa)
VS_2048Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (374 aa)
VS_2215PfaA, omega-3 polyunsaturated fatty acid synthase. (2604 aa)
sucDSuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
VS_2263Putative glutathione-regulated potassium-efflux system protein KefB; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (528 aa)
VS_2278Hypothetical UPF0105 protein yfcH. (304 aa)
VS_2279Hypothetical oxidoreductase ybbO. (275 aa)
dxrPutative 1-deoxy-D-xylulose 5-phosphate reductoisomeras; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (361 aa)
VS_2567NADPH:quinone reductase. (319 aa)
VS_2640D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
epdD-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (353 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa)
kefBGlutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (599 aa)
VS_II15013-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (291 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
VS_2893Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (803 aa)
VS_2896NADP-dependent malic enzyme. (429 aa)
VS_2957Phosphoglycerate dehydrogenase. (308 aa)
VS_3033Glyceraldehyde-3-phosphate dehydrogenase 3; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (276 aa)
VS_3129Potassium uptake protein TrkA. (458 aa)
VS_II0078Hypothetical protein. (354 aa)
VS_II0089Probable oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (279 aa)
VS_II0126Putative oxidoreductase. (324 aa)
VS_II0150D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
VS_II0250Hypothetical protein. (328 aa)
VS_II0346Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (478 aa)
VS_II0391KtrA. (218 aa)
VS_II04096-phosphogluconate dehydrogenase, decarboxylating 2; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (502 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (343 aa)
VS_II0440Glutathione-regulated potassium-efflux system protein kefC (K(+)/H(+)antiporter); Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (641 aa)
VS_II0556Putative NADP-dependent oxidoreductase. (343 aa)
VS_II0584Acetoacetyl-CoA reductase. (246 aa)
VS_II0732NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (515 aa)
VS_II0748Acyl-CoA synthetase. (893 aa)
VS_II0752UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (337 aa)
VS_II0756Hypothetical protein. (484 aa)
fabV-2Putative reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (399 aa)
VS_II1120Zinc-containing alcohol dehydrogenase superfamily; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (341 aa)
VS_II1221Hypothetical oxidoreductase. (326 aa)
VS_II1272Putative NADH-flavin reductase. (212 aa)
VS_II1274Putative oxidoreductase. (279 aa)
VS_II1277Oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (239 aa)
VS_II1327Putative alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (382 aa)
VS_II1453Short-chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
VS_II1477Putative dehydrogenase. (227 aa)
VS_II1462Putative short-chain dehydrogenase. (224 aa)
VS_0039Zinc-binding dehydrogenase. (326 aa)
fadBFatty oxidation complex, alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (723 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (494 aa)
waaDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (328 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD+); Function of homologous gene experimentally demonstrated in another organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (370 aa)
rffGdTDP-D-glucose-4,6-dehydratase; Function of homologous gene experimentally demonstrated in another organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (358 aa)
VS_0230Putative dTDP-4-dehydrorhamnose reductase (rfbD); Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (286 aa)
VS_0232Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (282 aa)
VS_0234Putative capsular polysaccharide biosynthesis protein (capD); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (643 aa)
VS_0352Putative 2-hydroxyacid dehydrogenase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (269 aa)
VS_0483Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (819 aa)
VS_0548TyrA, Chorismate mutase T-prephenate dehydrogenase. (375 aa)
VS_06842-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (297 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (419 aa)
VS_07713-oxoacyl-[acyl-carrier-protein] reductase. (241 aa)
fadJFatty acid oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (748 aa)
folDFolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (377 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa)
VS_0932Glyceraldehyde-3-phosphate dehydrogenase A; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (367 aa)
VS_0942Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (228 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa)
VS_0959Oxidoreductase, short-chain dehydrogenase/reductase family. (227 aa)
Your Current Organism:
Vibrio tasmaniensis
NCBI taxonomy Id: 575788
Other names: V. tasmaniensis LGP32, Vibrio lentus MEL32, Vibrio splendidus LGP32, Vibrio tasmaniensis LGP32
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