(17 nodes) Cargo concentration in the ER network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EHI_075040	GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family. (190 aa)
	16.t00024	Uncharacterized protein. (459 aa)
	237.t00006	Vesicular integral membrane protein VIP36, putative. (414 aa)
	38.t00038	Vesicular integral membrane protein VIP36, putative. (380 aa)
	178.t00014	Sec24 protein, putative. (655 aa)
	79.t00024	Uncharacterized protein. (543 aa)
	377.t00003	GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family. (190 aa)
	149.t00022	Vesicular integral membrane protein VIP36, putative. (410 aa)
	184.t00009	Uncharacterized protein. (148 aa)
	17.t00038	EhSec24E. (562 aa)
	698.t00002	Protein transport protein Sec24, putative. (876 aa)
	1.t00002	SEC-24 protein, putative. (647 aa)
	111.t00020	Sec24 protein, putative. (618 aa)
	315.t00007	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (726 aa)
	98.t00012	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (721 aa)
	118.t00015	WD domain containing protein. (998 aa)
	264.t00015	Sec 13 protein, putative; Belongs to the WD repeat SEC13 family. (261 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00002	111.t00020	Q1EQ47	Q1EQ48	SEC-24 protein, putative.	Sec24 protein, putative.	0.615
1.t00002	118.t00015	Q1EQ47	Q1EQ51	SEC-24 protein, putative.	WD domain containing protein.	0.987
1.t00002	149.t00022	Q1EQ47	C4MAP1	SEC-24 protein, putative.	Vesicular integral membrane protein VIP36, putative.	0.556
1.t00002	16.t00024	Q1EQ47	C4LTL0	SEC-24 protein, putative.	Uncharacterized protein.	0.948
1.t00002	17.t00038	Q1EQ47	Q1EQ44	SEC-24 protein, putative.	EhSec24E.	0.927
1.t00002	178.t00014	Q1EQ47	C4M0D2	SEC-24 protein, putative.	Sec24 protein, putative.	0.926
1.t00002	184.t00009	Q1EQ47	C4MAS2	SEC-24 protein, putative.	Uncharacterized protein.	0.713
1.t00002	237.t00006	Q1EQ47	C4LZ13	SEC-24 protein, putative.	Vesicular integral membrane protein VIP36, putative.	0.554
1.t00002	264.t00015	Q1EQ47	Q1EQ52	SEC-24 protein, putative.	Sec 13 protein, putative; Belongs to the WD repeat SEC13 family.	0.997
1.t00002	315.t00007	Q1EQ47	Q1EQ49	SEC-24 protein, putative.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.949
1.t00002	377.t00003	Q1EQ47	C4M4L8	SEC-24 protein, putative.	GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family.	0.944
1.t00002	38.t00038	Q1EQ47	C4LZ48	SEC-24 protein, putative.	Vesicular integral membrane protein VIP36, putative.	0.551
1.t00002	698.t00002	Q1EQ47	Q1EQ46	SEC-24 protein, putative.	Protein transport protein Sec24, putative.	0.927
1.t00002	79.t00024	Q1EQ47	C4M306	SEC-24 protein, putative.	Uncharacterized protein.	0.456
1.t00002	98.t00012	Q1EQ47	Q1EQ50	SEC-24 protein, putative.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.948
1.t00002	EHI_075040	Q1EQ47	B1N4P1	SEC-24 protein, putative.	GTP-binding protein; Belongs to the small GTPase superfamily. SAR1 family.	0.944
111.t00020	1.t00002	Q1EQ48	Q1EQ47	Sec24 protein, putative.	SEC-24 protein, putative.	0.615
111.t00020	118.t00015	Q1EQ48	Q1EQ51	Sec24 protein, putative.	WD domain containing protein.	0.987
111.t00020	149.t00022	Q1EQ48	C4MAP1	Sec24 protein, putative.	Vesicular integral membrane protein VIP36, putative.	0.558
111.t00020	16.t00024	Q1EQ48	C4LTL0	Sec24 protein, putative.	Uncharacterized protein.	0.949