(49 nodes) Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	15.t00016	rRNA processing protein, putative. (208 aa)
	EHI_038320	UPF0113 domain-containing protein. (59 aa)
	EHI_038310	60S ribosome subunit biogenesis protein NIP7, putative. (86 aa)
	EHI_170290	Nuclear complex protein 4, putative. (235 aa)
	EHI_094780	Pescadillo homolog, putative. (163 aa)
	611.t00001	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	EHI_059540	Brix domain-containing protein 1, putative. (153 aa)
	2.t00019	DEAD/DEAH box helicase, putative; Belongs to the DEAD box helicase family. (499 aa)
	16.t00022	Brix domain containing protein. (353 aa)
	215.t00011	Nucleolar phosphoprotein Nopp34, putative. (153 aa)
	221.t00012	Ribosome biogenesis protein, putative. (311 aa)
	32.t00007	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (684 aa)
	34.t00039	Protein MAK16 homolog; Belongs to the MAK16 family. (264 aa)
	39.t00015	Proliferating-cell nucleolar antigen p120, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (495 aa)
	155.t00010	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	214.t00010	GTP binding protein, putative. (463 aa)
	62.t00014	Uncharacterized protein. (541 aa)
	18.t00050	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (406 aa)
	47.t00017	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (730 aa)
	38.t00035	Pumilio family RNA-binding protein. (551 aa)
	578.t00005	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (411 aa)
	106.t00003	WD domain containing protein. (409 aa)
	64.t00021	Uncharacterized protein. (411 aa)
	86.t00036	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (656 aa)
	86.t00008	60S ribosomal protein L24, putative. (179 aa)
	262.t00002	Peptidase, putative. (372 aa)
	262.t00008	Ribosome biogenesis protein, putative. (291 aa)
	368.t00004	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (545 aa)
	68.t00026	RNA recognition motif domain containing protein. (264 aa)
	408.t00006	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (611 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (239 aa)
	335.t00010	Helicase, putative; Belongs to the DEAD box helicase family. (522 aa)
	199.t00012	Zinc finger protein, putative. (140 aa)
	74.t00033	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (605 aa)
	268.t00004	Uncharacterized protein. (930 aa)
	166.t00002	DEAD/DEAH box helicase, putative. (551 aa)
	63.t00023	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	341.t00009	WD domain containing protein. (405 aa)
	29.t00039	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (829 aa)
	186.t00024	Uncharacterized protein. (579 aa)
	31.t00031	WD domain containing protein. (517 aa)
	115.t00005	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (258 aa)
	297.t00009	Ccaat-box-binding transcription factor, putative. (718 aa)
	223.t00007	RNA helicase. (542 aa)
	302.t00001	Uncharacterized protein. (298 aa)
	9.t00076	Nucleolar complex protein 2 homolog, putative. (508 aa)
	289.t00009	Ribosome biogenesis protein, putative. (295 aa)
	447.t00009	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (225 aa)
	517.t00001	DEAD/DEAH box helicase, putative; Belongs to the DEAD box helicase family. (600 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
106.t00003	115.t00005	C4LZA3	C4M883	WD domain containing protein.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.840
106.t00003	15.t00016	C4LZA3	B1N2M7	WD domain containing protein.	rRNA processing protein, putative.	0.898
106.t00003	155.t00010	C4LZA3	C4LX57	WD domain containing protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.815
106.t00003	16.t00022	C4LZA3	C4LTL2	WD domain containing protein.	Brix domain containing protein.	0.757
106.t00003	166.t00002	C4LZA3	C4M4E5	WD domain containing protein.	DEAD/DEAH box helicase, putative.	0.698
106.t00003	18.t00050	C4LZA3	C4LYY7	WD domain containing protein.	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family.	0.810
106.t00003	186.t00024	C4LZA3	C4M7Y4	WD domain containing protein.	Uncharacterized protein.	0.586
106.t00003	199.t00012	C4LZA3	C4M3F5	WD domain containing protein.	Zinc finger protein, putative.	0.762
106.t00003	2.t00019	C4LZA3	C4LSG3	WD domain containing protein.	DEAD/DEAH box helicase, putative; Belongs to the DEAD box helicase family.	0.841
106.t00003	214.t00010	C4LZA3	C4LY91	WD domain containing protein.	GTP binding protein, putative.	0.570
106.t00003	215.t00011	C4LZA3	C4LU58	WD domain containing protein.	Nucleolar phosphoprotein Nopp34, putative.	0.863
106.t00003	221.t00012	C4LZA3	C4LVY6	WD domain containing protein.	Ribosome biogenesis protein, putative.	0.839
106.t00003	223.t00007	C4LZA3	C4M8U4	WD domain containing protein.	RNA helicase.	0.677
106.t00003	262.t00002	C4LZA3	C4LZM7	WD domain containing protein.	Peptidase, putative.	0.499
106.t00003	262.t00008	C4LZA3	C4LZN4	WD domain containing protein.	Ribosome biogenesis protein, putative.	0.877
106.t00003	268.t00004	C4LZA3	C4M457	WD domain containing protein.	Uncharacterized protein.	0.532
106.t00003	289.t00009	C4LZA3	C4MAW7	WD domain containing protein.	Ribosome biogenesis protein, putative.	0.898
106.t00003	29.t00039	C4LZA3	C4M6R5	WD domain containing protein.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.647
106.t00003	297.t00009	C4LZA3	C4M8Q0	WD domain containing protein.	Ccaat-box-binding transcription factor, putative.	0.824
106.t00003	302.t00001	C4LZA3	C4M977	WD domain containing protein.	Uncharacterized protein.	0.797