(21 nodes) Preribosome, large subunit precursor, and CBF/Mak21 family network (Entamoeba histolytica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	15.t00016	rRNA processing protein, putative. (208 aa)
	16.t00022	Brix domain containing protein. (353 aa)
	215.t00011	Nucleolar phosphoprotein Nopp34, putative. (153 aa)
	221.t00012	Ribosome biogenesis protein, putative. (311 aa)
	34.t00039	Protein MAK16 homolog; Belongs to the MAK16 family. (264 aa)
	39.t00015	Proliferating-cell nucleolar antigen p120, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (495 aa)
	18.t00050	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (406 aa)
	262.t00008	Ribosome biogenesis protein, putative. (291 aa)
	368.t00004	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (545 aa)
	74.t00033	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (605 aa)
	166.t00002	DEAD/DEAH box helicase, putative. (551 aa)
	63.t00023	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	29.t00039	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (829 aa)
	186.t00024	Uncharacterized protein. (579 aa)
	115.t00005	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (258 aa)
	297.t00009	Ccaat-box-binding transcription factor, putative. (718 aa)
	223.t00007	RNA helicase. (542 aa)
	302.t00001	Uncharacterized protein. (298 aa)
	9.t00076	Nucleolar complex protein 2 homolog, putative. (508 aa)
	289.t00009	Ribosome biogenesis protein, putative. (295 aa)
	447.t00009	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (225 aa)

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
115.t00005	15.t00016	C4M883	B1N2M7	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	rRNA processing protein, putative.	0.996
115.t00005	16.t00022	C4M883	C4LTL2	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Brix domain containing protein.	0.945
115.t00005	166.t00002	C4M883	C4M4E5	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	DEAD/DEAH box helicase, putative.	0.857
115.t00005	18.t00050	C4M883	C4LYY7	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family.	0.983
115.t00005	186.t00024	C4M883	C4M7Y4	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Uncharacterized protein.	0.817
115.t00005	215.t00011	C4M883	C4LU58	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Nucleolar phosphoprotein Nopp34, putative.	0.995
115.t00005	221.t00012	C4M883	C4LVY6	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome biogenesis protein, putative.	0.944
115.t00005	223.t00007	C4M883	C4M8U4	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	RNA helicase.	0.681
115.t00005	262.t00008	C4M883	C4LZN4	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome biogenesis protein, putative.	0.945
115.t00005	289.t00009	C4M883	C4MAW7	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome biogenesis protein, putative.	0.994
115.t00005	29.t00039	C4M883	C4M6R5	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.937
115.t00005	297.t00009	C4M883	C4M8Q0	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ccaat-box-binding transcription factor, putative.	0.818
115.t00005	302.t00001	C4M883	C4M977	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Uncharacterized protein.	0.964
115.t00005	34.t00039	C4M883	C4LWR5	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.934
115.t00005	368.t00004	C4M883	C4M0Q1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.935
115.t00005	39.t00015	C4M883	C4LWT4	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Proliferating-cell nucleolar antigen p120, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.911
115.t00005	447.t00009	C4M883	C4MAY8	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.962
115.t00005	63.t00023	C4M883	C4M4L2	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.916
115.t00005	74.t00033	C4M883	C4M3V4	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.	0.934
115.t00005	9.t00076	C4M883	C4M9H6	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	Nucleolar complex protein 2 homolog, putative.	0.967