STRINGSTRING
EHI_141410 EHI_141410 EHI_129730 EHI_129730 EHI_019060 EHI_019060 EHI_192770 EHI_192770 EHI_123830 EHI_123830 EHI_129630 EHI_129630 2.t00064 2.t00064 2.t00084 2.t00084 1.t00124 1.t00124 10.t00063 10.t00063 8.t00051 8.t00051 8.t00042 8.t00042 4.t00027 4.t00027 81.t00032 81.t00032 25.t00039 25.t00039 9.t00022 9.t00022 464.t00003 464.t00003 300.t00001 300.t00001 85.t00006 85.t00006 85.t00018 85.t00018 11.t00003 11.t00003 117.t00008 117.t00008 117.t00040 117.t00040 207.t00012 207.t00012 32.t00015 32.t00015 159.t00005 159.t00005 129.t00030 129.t00030 14.t00019 14.t00019 214.t00007 214.t00007 44.t00003 44.t00003 62.t00031 62.t00031 62.t00007 62.t00007 18.t00056 18.t00056 18.t00025 18.t00025 7.t00040 7.t00040 53.t00034 53.t00034 180.t00010 180.t00010 4.t00129 4.t00129 151.t00005 151.t00005 153.t00002 153.t00002 224.t00013 224.t00013 75.t00025 75.t00025 MCM7 MCM7 102.t00005 102.t00005 40.t00023 40.t00023 73.t00009 73.t00009 199.t00007 199.t00007 60.t00010 60.t00010 100.t00007 100.t00007 63.t00006 63.t00006 98.t00004 98.t00004 139.t00016 139.t00016 192.t00009 192.t00009 232.t00012 232.t00012 147.t00013 147.t00013 1.t00017 1.t00017 59.t00008 59.t00008 146.t00025 146.t00025 141.t00006 141.t00006 113.t00017 113.t00017 111.t00004 111.t00004 318.t00007 318.t00007 135.t00016 135.t00016 173.t00021 173.t00021 FEN1 FEN1 51.t00007 51.t00007 321.t00010 321.t00010 167.t00005 167.t00005 213.t00004 213.t00004 277.t00004 277.t00004 115.t00028 115.t00028 227.t00011 227.t00011 158.t00009 158.t00009 234.t00004 234.t00004 290.t00003 290.t00003 59.t00030 59.t00030 180.t00016 180.t00016 345.t00011 345.t00011 113.t00021 113.t00021 319.t00002 319.t00002 17.t00015 17.t00015 161.t00010 161.t00010 562.t00001 562.t00001 513.t00002 513.t00002 48.t00008 48.t00008 393.t00005 393.t00005
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHI_141410Uncharacterized protein. (395 aa)
EHI_129730Protein kinase rad3, putative; Belongs to the PI3/PI4-kinase family. (255 aa)
EHI_019060DNA mismatch repair protein mutS, putative. (225 aa)
EHI_192770Uncharacterized protein. (391 aa)
EHI_123830DNA mismatch repair protein Msh2, putative. (630 aa)
EHI_129630DNA primase small subunit, putative. (189 aa)
2.t00064DNA polymerase. (1132 aa)
2.t00084Uncharacterized protein. (579 aa)
1.t00124DNA repair endonuclease, putative. (882 aa)
10.t00063Meiotic recombination protein DMC1, putative; Belongs to the RecA family. (347 aa)
8.t00051Replication factor A, putative. (569 aa)
8.t00042DNA polymerase. (1385 aa)
4.t00027Cell division control protein 45 CDC45, putative. (543 aa)
81.t00032RecQ family DNA helicase. (509 aa)
25.t00039Exonuclease I, putative. (486 aa)
9.t00022Nuclear transport factor 2, putative. (126 aa)
464.t00003Phosphatidylinositol 3-and 4-kinase family; Belongs to the PI3/PI4-kinase family. (2284 aa)
300.t00001DNA primase; Belongs to the eukaryotic-type primase small subunit family. (380 aa)
85.t00006DNA replication licensing factor MCM3; Belongs to the MCM family. (601 aa)
85.t00018DNA repair protein, putative. (884 aa)
11.t00003Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (595 aa)
117.t00008DNA mismatch repair protein mutL, putative. (615 aa)
117.t00040DNA excision repair protein, putative. (238 aa)
207.t00012DNA mismatch repair protein PMS1, putative. (876 aa)
32.t00015Uncharacterized protein. (199 aa)
159.t00005Asparaginyl-tRNA synthetase, putative. (451 aa)
129.t00030DNA primase large subunit, putative. (457 aa)
14.t00019Uncharacterized protein. (576 aa)
214.t00007Uncharacterized protein. (489 aa)
44.t00003Replication factor C subunit 4, putative. (329 aa)
62.t00031Uncharacterized protein. (210 aa)
62.t00007DNA helicase; Belongs to the MCM family. (682 aa)
18.t00056DNA helicase; Belongs to the MCM family. (881 aa)
18.t00025Checkpoint protein; Belongs to the HUS1 family. (260 aa)
7.t00040DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (607 aa)
53.t00034DNA polymerase. (1077 aa)
180.t00010Uncharacterized protein. (440 aa)
4.t00129DNA primase; Belongs to the eukaryotic-type primase small subunit family. (372 aa)
151.t00005DNA-repair protein, putative. (660 aa)
153.t00002Uncharacterized protein. (911 aa)
224.t00013Uncharacterized protein. (371 aa)
75.t00025DNA repair and recombination protein RAD52, putative. (242 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (690 aa)
102.t00005Uncharacterized protein. (1241 aa)
40.t00023DNA replication licensing factor, putative; Belongs to the MCM family. (810 aa)
73.t00009Activator 1 subunit, putative. (331 aa)
199.t00007Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2457 aa)
60.t00010DNA replication licensing factor, putative; Belongs to the MCM family. (733 aa)
100.t00007Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (308 aa)
63.t00006DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (366 aa)
98.t00004Zinc finger domain containing protein. (229 aa)
139.t00016MutS family protein. (934 aa)
192.t00009RecQ family helicase, putative. (1182 aa)
232.t00012ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (774 aa)
147.t00013Uncharacterized protein. (719 aa)
1.t00017DNA ligase. (685 aa)
59.t00008DNA repair protein RAD51C, putative. (283 aa)
146.t00025DNA mismatch repair protein MLH1, putative. (702 aa)
141.t00006Uncharacterized protein. (430 aa)
113.t00017DNA replication complex GINS protein PSF1, putative. (189 aa)
111.t00004DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (840 aa)
318.t00007Activator 1 subunit, putative. (345 aa)
135.t00016Uncharacterized protein. (244 aa)
173.t00021Replication factor C familiy protein. (325 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (376 aa)
51.t00007DNA primase large subunit, putative. (523 aa)
321.t00010Uncharacterized protein. (796 aa)
167.t00005DNA repair helicase, putative. (1033 aa)
213.t00004DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (319 aa)
277.t00004Activator 1 140 kDa subunit, putative. (718 aa)
115.t00028DNA mismatch repair protein mutS, putative. (755 aa)
227.t00011DNA repair protein, putative. (764 aa)
158.t00009Uncharacterized protein. (103 aa)
234.t00004Replication factor A protein 1, putative. (588 aa)
290.t00003Mre11, putative. (223 aa)
59.t00030Deoxycytidyl transferase, putative. (708 aa)
180.t00016Activator 1 40 kDa subunit, putative. (315 aa)
345.t00011DNA replication licensing factor, putative; Belongs to the MCM family. (608 aa)
113.t00021DNA mismatch repair protein Msh2, putative. (630 aa)
319.t00002Uncharacterized protein. (372 aa)
17.t00015Rad52/22 family double-strand break repair protein, putative. (189 aa)
161.t00010Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
562.t00001DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (204 aa)
513.t00002Exonuclease I, putative. (497 aa)
48.t00008Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (414 aa)
393.t00005DNA helicase; Belongs to the MCM family. (639 aa)
Your Current Organism:
Entamoeba histolytica
NCBI taxonomy Id: 5759
Other names: E. histolytica
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